Biophysical Society 65th Annual Meeting Program Guide

1192-Pos B oard B242 CA 2+ -ACTIVATED K + CHANNEL K CA 3.1 REGULATES IL-10 EXPRESSION IN REG- ULATORY T CELLS AT THE RECOVERY PHASE OF INFLAMMATORY BOWEL DISEASE MODEL. Susumu Ohya , Miki Matsui, Junko Kajikuri, Kyoko Endo, Hiroaki Kito 1193-Pos B oard B243 SUPPRESSION OF KV1.1 CHANNEL ACTIVITY BY BETA-AMYLOID PEPTIDES INVOLVES BOTH INTRACELLULAR CALCIUM-SIGNALING AND DIRECT PEPTIDE-PEPTIDE INTERACTIONS. Joseph Farley , Kristi DeBoeuf, Moham- mad F. Islam, Nicholas Thelen, Joshua M. Watkins 1194-Pos B oard B244 A NOVEL SPIDER PEPTIDE THAT AFFECTS THE VOLTAGE GATED POTAS- SIUM CHANNEL KV1.5. Agota Csoti, Diana Alvarado, Samuel Cardoso-Are- nas, Ligia-Luz Corrales-García, Herlinda Clement, Iván Arenas, Pavel Andrei Montero-Dominguez, Timoteo Olamendi-Portugal, Fernando Z. Zamudio, Jesús Borrego, Gyorgy Panyi, Zoltan Varga, Gerardo Corzo, Ferenc Papp 1195-Pos B oard B245 ELECTROPHYSIOLOGICAL CHARACTERIZATION OF CATSPER CHANNEL IN SEA URCHIN SPERM. Veronica Loyo Celis , Gerardo Orta, Carmen Beltran, Alberto Darszon 1196-Pos B oard B246 THE MOLECULAR BASIS OF THE REGULATION OF THE TMEM16A CA 2+ - ACTIVATED CL - CHANNEL BY THE LYSOSOMAL NPC1 PROTEIN. Lara F. Scofano , Kathryn E. Acheson, Claire Smith, Frances Platt, Paolo Tammaro 1197-Pos B oard B247 MOLECULAR DYNAMICS TO EXPLAIN THE PATHOGENESIS OF GATING CLASS CYSTIC FIBROSIS MUTATIONS. Miro A. Astore , Po-Chia Chen, Shaf- agh Waters, Serdar Kuyucak 1198-Pos B oard B248 KINETIC MODEL DISTINGUISHES SUBANESTHETIC DOSES OF KETAMINE BLOCK ON SINGLE CHANNEL N-METHYL-D-ASPARTATE RECEPTORS FROM EFFECTS OF PROTONS. Jamie A. Abbott 1199-Pos B oard B249 MECHANISTIC INSIGHTS INTO VOLATILE ANESTHETIC MODULATION OF K2P CHANNELS. Paul M. Riegelhaupt 1200-Pos B oard B250 A “RECEPTOPHORE MODEL” FOR LOCAL ANESTHETICS BINDING SITE IN CARDIAC ION CHANNELS. Wendy Gonzalez , Gabriel Nuñez-Vivanco, David Ramírez, Aytug K. Kiper, Susanne Rinne, Mauricio Bedoya, Bárbara Arévalo, José Márquez-Montesinos, Miguel Reyes-Parada, Vladimir Yarov- Yarovoy, Niels Decher 1201-Pos B oard B251 IDENTIFYING NOVEL ISOFORM-SPECIFIC HCN CHANNEL LIGANDS USING SPR. Pareesa E. Kamgar-Dayhoff , Purushottam Tiwari, Tinatin I. Brelidze 1202-Pos B oard B252 UNATTENDED DRUG DISCOVERY SCREENING WORKFLOW IN A 384-WELL AUTOMATED PATCH CLAMP SYSTEM. Nina Brinkwirth, Alison Obergruss- berger, Nadine Becker, Tim Strassmaier , James L. Costantin, Claudia S. Haarmann, Rodolfo Haedo, Niels Fertig, Sonja Stoelzle-Feix Cardiac Muscle Mechanics and Structure (Boards B253 - B278) 1203-Pos B oard B253 INVESTIGATING THE EFFECTS OF MUTATIONS WITHIN THE COILED-COIL TAIL OF CARDIAC AND SKELETAL MYOSIN. Glenn Carrington , Francine Parker, Marta Giralt-Pujol, Michelle Peckham

1204-Pos B oard B254 THE M DOMAIN OF CARDIAC MYOSIN BINDING PROTEIN-C IS NECESSARY TO DAMP SPOC IN SPY-C CARDIOMYOCYTES. Nichlas M. Engels , Rachel Sadler, Samantha Harris 1205-Pos B oard B255 ENHANCING CARDIAC MYOSIN FUNCTION WITH AN ABIOTIC ENERGY SOURCE. Mike K. Woodward , Eric Ostrander, Brent D. Scott, Christopher Marang, Xiaorong Liu, Jianhan Chen, Dhandapani Venkataraman, Edward B oard B256 OMECAMTIV MECARBIL MODULATION OF FORCE GENERATION IN SINGLE MYOFIBRILS FROM HUMAN CARDIAC MUSCLE. Beatrice Scellini, Nicoletta Piroddi, Marica Dente, Giulia Vitale, Raffaele Coppini, Cecilia Ferrantini, Corrado Poggesi, Chiara Tesi 1207-Pos B oard B257 AMPLIFICATION OF CARDIAC MOTOR FUNCTIONS BY PRESTIN (SL- C26A5). Xiao-Dong Zhang , Phung Thai, Lu Ren, Maria Cristina Perez Flores, Hannah A. Ledford, Seojin Park, Jeong Han Lee, Choong-Ryoul Sihn, Che-Wei Chang, Wei Chun Chen, Valeriy Timofeyev, Jian Zuo, James W. Chan, Ebenezer N. Yamoah, Nipavan Chiamvimonvat 1208-Pos B oard B258 MOLECULAR MECHANISM OF FORCE GENERATION BY THE ACTIN-MYOSIN COMPLEX DURING CARDIAC MUSCLE CONTRACTION. Wen Ma , Shengjun You, Michael Regnier, J. AndrewMcCammon 1209-Pos B oard B259 SIMULATING CARDIAC MUSCLE MUTATIONS IN A COMPLIANT LATTICE WITH COMMONLY USED ASSAYS. Anthony Asencio , Michael Regnier, Thomas L. Daniel, Farid Moussavi-Harami 1210-Pos B oard B260 MAPPING THE CARDIAC TROPONIN T LINKER REGION TO ACTIN AND DETERMINING PATHOGENIC POINT MUTATIONAL EFFECTS. Andrea E. Deranek , Anthony Baldo, Steven D. Schwartz, Jil C. Tardiff 1211-Pos B oard B261 CARDIAC TROPONIN I N-TERMINAL PSEUDO-PHOSPHORYLATION REGU- LATES POWER OUTPUT AND STRETCH ACTIVATION. Joel C. Robinett , Laurin M. Hanft, Brandon J. Biesiadecki, Kerry S. McDonald 1212-Pos B oard B262 ELUCIDATING THE STRUCTURAL INTERACTION BETWEEN N- AND C- TERMINI OF HUMAN ADULT CARDIAC TROPONIN T. Garrett Crosby 1213-Pos B oard B263 AN ATOMIC MODEL OF THE THIN FILAMENT DESCRIBING TROPONIN-I -TROPOMYOSIN BINDING AT LOW-CALCIUM. William Lehman , Michael J. Rynkiewicz 1214-Pos B oard B264 HIGH-THROUGHPUT FLUORESCENCE LIFETIME-BASED SCREEN DETECTS COMPOUNDS THAT BIND TO MYOSIN-BINDING PROTEIN C AND MODU- LATE INTERACTIONS WITH ACTIN. Thomas A. Bunch, Piyali Guhathakurta, Andrew R. Thompson, Victoria C. Lepak, David D. Thomas, Brett A. Colson 1215-Pos B oard B265 CONFORMATION OF S1-S2 COMPLEX OF HUMAN CARDIAC MYOSIN RE- VEALED BY FRET. Alexandra N. Hurst , Akhil Gargey, Yuri Nesmelov 1216-Pos B oard B266 STRUCTURAL CHANGES IN THE MYOSIN MOTORS INDUCED BY STRETCH AND PHOSPHORYLATION OF THE MYOSIN REGULATORY LIGHT CHAIN IN RAT CARDIAC TRABECULAE. So-Jin Park-Holohan, Elisabetta Brunello, Thomas Kampourakis, Martin Rees, Malcolm Irving, Luca Fusi P. Debold 1206-Pos

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