Biophysical Society 65th Annual Meeting Program Guide

Microtubules, Structure, Dynamics, and Associated Proteins (Boards B279 - B296) 1229-Pos B oard B279 A STRUCTURE-BASED MECHANISTIC MODEL OF MICROTUBULE PLUS- END CATASTROPHE. Kenneth K. Tsui , Shannon F. Stewman, Ao Ma 1230-Pos B oard B280 CATCHING THE CONFORMATIONAL WAVE: TUNING THE WORKING STROKES OF PROTOFILAMENTS AS THEY CURL OUTWARDS FROM DISAS- SEMBLING MICROTUBULE TIPS. Lucas Murray , Haein Kim, Luke Rice, Charles L. Asbury 1231-Pos B oard B281 DYNAMIC INSTABILITY FROM NON-EQUILIBRIUM STRUCTURAL TRANSI- TIONS ON THE ENERGY LANDSCAPE OF MICROTUBULE. Shannon F. Stew- man, Kenneth Tsui, Ao Ma 1232-Pos B oard B282 DIVALENT CATIONS INDUCE NON-EQUILIBRIUM PHASE TRANSITIONS IN TAU-MEDIATED MICROTUBULE BUNDLES UNDERGOING DYNAMIC INSTABILITY. Bretton Fletcher , Phillip A. Kohl, Chaeyeon Song, Christine Tchounwou, Peter J. Chung, Herbert P. Miller, Youli Li, Myung Chul Choi, Leslie Wilson, Stuart C. Feinstein, Cyrus R. Safinya 1233-Pos B oard B283 TWIST-BENDING ELASTICITY AND ENERGETICS OF THE PLUS-END MICRO- TUBULE TIP CAPTURED BY EXASCALE ATOMISTIC SIMULATIONS. Maxim Igaev , Helmut Grubmueller 1234-Pos B oard B284 ELECTRICAL OSCILLATIONS OF ISOLATED BRAIN MICROTUBULES. Brenda C. Gutierrez, Horacio F. Cantiello, María del Rocío Cantero 1235-Pos B oard B285 OXIDATIVE STRESS-INDUCED STRUCTURAL DEFECTS WITHIN THE MI- CROTUBULE LATTICE INDUCE TUBULIN ACETYLATION BY ATAT1. Rebecca R. Goldblum , Scout Allendorf, Mark McClellan, Kyle White, Joseph M. Metzger, Melissa K. Gardner 1236-Pos B oard B286 MICROTUBULE GROWTH IS SLOWED THROUGH TRANSIENT EXPOSURE OF GDP TUBULIN. Joseph M. Cleary , Tae Kim, Luke M. Rice, William O. B oard B287 MICROTUBULE-BASED TRANSPORT IS CONTROLLED BY TUBULIN TAILS AND THEIR MODIFICATIONS. Lavi S. Bigman , Koby Levy 1238-Pos B oard B288 INFLUENCE OF KINESIN-1 GLIDING ON MICROTUBULE RIGIDITY. Brandon J. Harris, Augustus Lowry, Kendra M. Kreienbrink, Anh T. Hoang, Douglas S. Martin , Taviare L. Hawkins 1239-Pos B oard B289 THE INFLUENCE OF MICROTUBULE PERSISTENCE LENGTH ON THEIR COL- LECTIVE MOTION. Hang Zhou , Wonyeong Jung, Tamanna Ishrat Farhana, Taeyoon Kim, Ryuji Yokokawa 1240-Pos B oard B290 DIFFERENTIAL REGULATION OF SINGLE MICROTUBULES AND CROSS- LINKED BUNDLES BY A MINIMAL THREE-PROTEIN MODULE. Nandini Mani , Shuo Jiang, Alex E. Neary, Sithara S. Wijeratne, Radhika Subrama- nian 1241-Pos B oard B291 TWO MODES OF PRC1-MEDIATED MECHANICAL RESISTANCE TO KINESIN- DRIVEN MICROTUBULE NETWORK DISRUPTION. April C. Alfieri , Ignas R. Gaska, Scott T. Forth Hancock 1237-Pos

1217-Pos B oard B267 CALCIUM DEPENDENCE OF MYOSIN FILAMENT STRUCTURE IN DEMEM- BRANATED TRABECULAE FROM RAT HEART. Luca Fusi, Yanhong Wang , So-Jin Park-Holohan, Andrea Ghisleni, Theyencheri Narayanan, Malcolm Irving, Elisabetta Brunello 1218-Pos B oard B268 UNUSUAL MOBILITY OF THE ELASTIC PROTEIN TITIN IN THIRTEEN-LINED GROUND SQUIRREL HEARTS. Jonathan R. Groening, Mark A. Hiske, Po-Jen Chiang, Maighdlin R. Patterson, Hannah V. Carey, Karen A. Ball, Charles S. Chung 1219-Pos B oard B269 CRYSTALLOGRAPHIC STRUCTURES OF TITIN IMMUNOGLOBULIN-LIKE I21 DOMAINS INVOLVED IN DILATED CARDIOMYOPATHY. Ines Martinez- Martin , Audrey Crousilles, Elias Herrero-Galan, Diana Velazquez-Carreras, Simon A. Mortensen, Pablo Garcia-Pavia, Jorge Alegre-Cebollada, Mat- thias Wilmanns 1220-Pos B oard B270 CREATION OF A MOLECULAR BAND-AID: DISEASE-LINKED DESMOPLA- KIN MUTATIONS ARE RESISTANT TO CALPAIN CLEAVAGE. Catherine A. Hoover , Heather R. Manring, Taylor Albertelli, Trevor Dew, Kendahl Ott, Nathan T. Wright, Maegen Borzok 1221-Pos B oard B271 MEMBRANE YOUNG’S MODULUS AS A FUNCTION OF PLAKOPHILIN-2 EXPRESSION: IMPLICATIONS TO ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY. Pamela Swiatlowska , Mario Delmar 1222-Pos B oard B272 MOLECULAR MECHANISMS AND CELLULAR MODELS OF HYPERTROPHIC CARDIOMYOPATHY: INSIGHTS FROM A SURPRISING MUTATION. Alison S. Vander Roest , Chao Liu, Kristina B. Kooiker, Makenna M. Morck, Beth Pruitt, Kenneth S. Campbell, Kathleen Ruppel, James A. Spudich, Daniel B oard B273 THE PROGRESSION OF DYSTROPHIN-DEFICIENT DILATED CARDIOMYOPA- THY THROUGH MECHANICAL AND CA 2+ DYSFUNCTION IN A DUCHENNE MUSCULAR DYSTROPHY RAT MODEL. Saffie Mohran , Shawn M. Luttrell, TimMcMillen, Kristina B. Kooiker, David L. Mack, Michael Regnier 1224-Pos B oard B274 A NOVEL METHOD TO MEASURE MYOFIBRIL STRAIN IN INTACT HUMAN STEM CELL DERIVED CARDIOMYOCYTES. Abigail Nagle , Michael Regnier, Jennifer M. Davis 1225-Pos B oard B275 STRUCTURE-FUNCTION INVESTIGATION OF THE E258K- MYBPC3 MUTA- TION IN HCM PATIENT-DERIVED CARDIOMYOCYTES. Sonette Steczina , J. Manuel Pioner, Saffie Mohran, Marianna Langione, Giulia Vitale, Beatrice Scellini, Nicoletta Piroddi, Cecilia Ferrantini, Chiara Tesi, Michael A. Geeves, Corrado Poggesi, Michael Regnier 1226-Pos B oard B276 DISEASE IN A DISH CRISPR-EDITED HIPSC-CMS TO STUDY THE CELLULAR AND SUBCELLULAR MECHANISMS OF HCM. Kerry Y. Kao , Matthew C. Childers, Saffie Mohran, Anthony Asencio, Michael Regnier 1227-Pos B oard B277 INVESTIGATING THE ROLE OF CONTRACTION DURING MYOFIBRIL FOR- MATION USING HUMAN STEM CELL-DERIVED CARDIOMYOCYTES. Dasom Yoo , An-yue Tu, Aidan Fenix, Michael Regnier 1228-Pos B oard B278 INVESTIGATING THE EFFECT OF HCM-ASSOCIATED TPM1 MUTATION S215L ON HUMAN ENGINEERED HEART TISSUES. Saiti S. Halder , Lorenzo R. Sewanan, Michael J. Rynkiewicz, Lindsey Howland, Jeffrey R. Moore, William Lehman, Stuart G. Campbell Bernstein 1223-Pos

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