Biophysical Society 65th Annual Meeting Program Guide

Platform Protein-Lipid Interactions II 12:00 pm - 1:30 pm

1372-Plat 1:15 pm GPCR OLIGOMERISATION MODULATION BY CONFORMATIONAL STATE AND LIPID INTERACTIONS REVEALED BY MD SIMULATIONS AND MARKOV MODELS. Wanling Song , Anna L. Duncan, Mark S. Sansom Platform Intrinsically Disordered Proteins (IDP) and Aggregates III 12:00 pm - 1:30 pm Chair Andela Saric, University College London, United Kingdom No Abstract 12:00 pm PATHWAYS OF AMYLOID FORMATION IN SOLUTION AND ON LIPID MEM- BRANES. Andela Saric 1373-Plat 12:30 pm THE INTERACTION BETWEEN POLY-PR DIPEPTIDE REPEAT PROTEINS AND THE NUCLEAR PORE COMPLEX. Hamidreza Jafarinia , Erik Van der Gies- sen, Patrick R. Onck 1374-Plat 12:45 pm MECHANISM FOR SCAVENGING OF AMYLOID-Β BY HYBRID SILICA NANOBOWLS: DIAGNOSTIC AND THERAPEUTIC APPLICATIONS FOR AΒ PATHOLOGY. Vrinda Sant , Madhura Som, Ratnesh Lal 1375-Plat 1:00 pm MOLECULAR ORIGINS OF FREE ENERGIES ASSOCIATED WITH COMPLEX INTERACTIONS OF BIOLOGICAL POLYELECTROLYTE-LIKE DISORDERED PROTEINS. Aritra Chowdhury , Andrea Sottini, Alessandro Borgia, Madeleine B. Borgia, Miloš T. Ivanović, Daniel Nettels, Robert B. Best, Benjamin Schuler 1376-Plat 1:15 pm THERAPEUTICS AGAINST PROTEIN MISFOLDED OLIGOMERS IN NEURO- DEGENERATIVE DISEASES. Ryan Limbocker , Aidan Wright, Ryan P. Kreiser, Benedetta Mannini, Michele Vendruscolo Platform RNA Structure and Dynamics 12:00 pm - 1:30 pm Chair Yamuna Krishnan, University of Chicago, USA No Abstract 12:00 pm THE MEMBRANE POTENTIAL OF ORGANELLES. Yamuna Krishnan 1377-Plat 12:30 pm COMPREHENSIVE SEQUENCE-TO-FUNCTION MAPPING OF LIGAND- DEPENDENT RNA CATALYSIS. Andrew Savinov , Johan O.L. Andreasson, Steven M. Block, William J. Greenleaf 1378-Plat 12:45 pm SINGLE BASE-PAIR CONFORMATIONAL SWITCH MODULATES MIR-34A TARGETING OF SIRT1 MRNA. Katja Petzold 1379-Plat 1:00 pm MAGNESIUMMEDIATED FLUORIDE BINDING ANCHORS THE DOCKED CONFORMATION OF THE FLUORIDE RIBOSWITCH. Rajeev Yadav , Julia R. Widom, Nils G. Walter 1380-Plat 1:15 pm ANTI-FRAMESHIFTING LIGAND ACTIVE AGAINST SARS CORONAVIRUS-2 IS RESISTANT TO NATURAL MUTATIONS OF THE FRAMESHIFT-STIMULATORY PSEUDOKNOT. Krishna Neupane, Sneha Munshi , Meng Zhao, Dustin Ritchie, Sandaru M. Ileperuma, Michael T. Woodside

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Chair Ling-Gang Wu, NIH, NINDS, USA 1381-Plat 12:00 pm

VISUALIZING MEMBRANE TRANSFORMATION IN MEDIATING ENDOCY- TOSIS AND GENERATING VARIOUS ENDOCYTIC MODES IN LIVE CELLS. Ling-Gang Wu , Wonchul Shin, Lisi Wei 1382-Plat 12:30 pm INTERFACIAL DELIVERY OF SURFACTANT PROTEIN SP-D THROUGH ITS ASSOCIATION WITH PULMONARY SURFACTANT. Cristina García Mouton , Alberto Hidalgo, Raquel Arroyo, Mercedes Echaide, Antonio Cruz, Jesus Perez-Gil 1383-Plat 12:45 pm PIP 2 PROMOTES CONFORMATION-SPECIFIC DIMERIZATION OF THE EPHA2 TRANSMEMBRANE DOMAIN THROUGH JUXTAMEMBRANE INTERAC- TIONS. Katherine M. Stefanski , Charles M. Russeull, Justin M. Wester- field, Rajan Lamichhane, Francisco N. Barrera 1384-Plat 1:00 pm PDK1 FORMS HOMODIMERS ON SUPPORTED LIPID BILAYERS IN A PIP 3 DEPENDENT MANNER. Moshe T. Gordon , Joseph J. Falke 1385-Plat 1:15 pm REVEALING THE DYNAMICS OF KRAS4B DIMERIZATION ON ANIONIC MEMBRANE FROM ONE MILLISECOND ALL ATOMMOLECULAR DYNAM- ICS SIMULATIONS. Van A. Ngo , Angel E. Garcia Platform Ion Channels, Pharmacology, and Disease 12:00 pm - 1:30 pm Chair Alexis Rohou, Genentech Inc., USA No Abstract 12:00 pm STRUCTURE OF THE SODIUM LEAK CHANNEL NALCN REVEALS INSIGHTS INTO ITS DISEASE MUTATIONS, UNIQUE PHARMACOLOGY AND GATING. Marc Kschonsak 1386-Plat 12:30 pm INTERPLAY OF NAV1.5 DISEASE-CAUSING MUTATIONS AND PHOSPHORY- LATION REVEALED BY PROTEIN SEMI-SYNTHESIS AND MOLECULAR DYNAMICS SIMULATIONS. Iacopo Galleano, Hendrik Harms , Koushik Choudhury, Keith K. Khoo, Lucie Delemotte, Stephan A. Pless 1387-Plat 12:45 pm HERG1A/1B SUBUNIT IMBALANCE IN LONG QT SYNDROME 2 PATIENT- SPECIFIC IPSC-CARDIOMYOCYTES. Li Feng , Jianhua Zhang, ChangHwan Lee, Gina Kim, Fang Liu, Andrew J. Petersen, Evi Lim, Corey Anderson, Kate M. Orland, Gail A. Robertson, Lee Eckhardt, Craig T. January, Timothy J. Kamp 1388-Plat 1:00 pm AN EPILEPSY-ASSOCIATED MUTATION AT THE K V 1.2 (KCNA2) CHARGE TRANSFER CENTER STRONLY SUPPRESSES CHANNEL SURFACE TRAF- FICKING. Sarah H. Lindström , Maki Kaneko, Michelle Nilsson, Federica Steccanella, Marina Angelini, Deborah Holder, Michela Ottolia, Riccardo Olcese, Antonios Pantazis 1389-Plat 1:15 pm STRUCTURAL BASIS FOR GATING OF THE TWO-PORE DOMAIN K + (K 2P ) CHANNELS TASK-1 AND TALK-2. Marcus Schewe , Elena B. Riel, Susanne Rinné, Wojciech Kopec, Jan Langer, Peter Lindemann, Björn C. Jürs, Marc Nazaré, Bert L. de Groot, Niels Decher, Thomas Baukrowitz

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