Biophysical Society 66th Annual Meeting Program Guide

937-Pos Board B78 A 2A ADENOSINE RECEPTOR CONFORMATIONAL DYNAMICS REVEALED BY SINGLE-MOLECULE FLUORESCENCE. Shushu Wei , Naveen Thakur, Arka Prabha Ray, Beining Jin, Samuel Obeng, Christopher R. McCurdy, Lance R. McMahon, Hugo Gutiérrez-de-Terán, Matthew T. Eddy, Rajan Lamichhane 938-Pos Board B79 Travel Award Winner REGULATION OF HUMAN A 2A ADENOSINE RECEPTOR CONFORMATIONAL DYNAMICS BY ENDOGENOUS PHOSPHOLIPIDS. Naveen Thakur , Arka Prabha Ray, Liam Sharp, Niloofar Gopal Pour, Zhan-Guo Gao, Samuel Obeng, Beining Jin, Anuradha V. Wijesekara, Alexander Duong, Christo - pher R. McCurdy, Lance R. McMahon, Kenneth A. Jacobson, Edward R. Lyman, Matthew T. Eddy 939-Pos Board B80 STRUCTURAL BASIS FOR REGULATION OF A HUMAN GPCR BY MEM - BRANE LIPIDS INVESTIGATED BY NMR SPECTROSCOPY. Matthew T. Eddy , Naveen Thakur, Arka Prabha Ray, Liam Sharp, Niloofar Gopal Pour, Zhan-Guo Gao, Samuel Obeng, Beining Jin, Anuradha V. Wijesekara, Alexander Duong, Christopher R. McCurdy, Lance R. McMahon, Kenneth A. Jacobson, Edward R. Lyman 940-Pos Board B81 UNRAVELING NEUROTENSIN RECEPTOR 1 CONFORMATIONAL LAND - SCAPE WITH MACHINE LEARNING. Prakarsh Yadav , Amir Barati Farimani 941-Pos Board B82 UNDERSTANDING THE LOSS OF CXCR4-MEDIATED SIGNALLING IN THE PRESENCE OF OXYSTEROLS. Anant Verma , Ganapathy Ayappa, Deepak K. Saini 942-Pos Board B83 ELUCIDATING ALLOSTERIC COMMUNICATION IN THE HUMAN SERO - TONIN TRANSPORTER. Erika Lazzarin , Ralph Gradisch, Leticia Alves da Silva, Thomas Stockner 943-Pos Board B84 SUBSTRATE-TRIGGERED OCCLUSION IN THE HUMAN SEROTONIN TRANS - PORTER UNVEILED A NEW AND FULLY OCCLUDED STRUCTURE. Ralph Gradisch , Dániel Szöllősi, Marco Niello, Harald Sitte, Thomas Stockner 944-Pos Board B85 CHARACTERIZING ANTIBODY BINDING TO INFLUENZA SURFACE PROTEINS AT THE VIRION LEVEL. Ananya Benegal , Michael Vahey 945-Pos Board B86 INVESTIGATING SARS-COV-2 ORF7A AND BST-2 HETERODIMERIZATION BY MOLECULAR DYNAMICS SIMULATIONS. Min-Kang Hsieh, Jeffery B. Klauda 946-Pos Board B87 STRUCTURAL DYNAMICS OF PREFUSION SPIKE PROTEIN OF SARS-COV-2 AND ITS VARIANTS. Mortaza Derakhshani-Molayousefi , Ugochi Isu, Mahmoud Moradi 947-Pos Board B88 WHOLE VIRION SIMULATIONS UNVEILING THE HEMAGGLUTININ- NEURAMINIDASE INTERPLAY. Christian Seitz , Lorenzo Casalino, J. Andrew McCammon, Rommie E. Amaro 948-Pos Board B89 STUDYING STRUCTURAL AND DYNAMIC PROPERTIES OF KCNE3 IN DIF - FERENT MEMBRANE MIMIC SYSTEMS USING MOLECULAR DYNAMICS SIMULATIONS. Isaac Asare , Alberto Perez, Andres G. Bastidas, Umesh Adhikari, Conner Campbell, Matthew Scheyer, Andrea Kravats, Gary A. Lorigan, Indra D. Sahu 949-Pos Board B90 COMPARING THE STRUCTURAL DYNAMICS OF THE HUMAN KCNE3 RECONSTITUTED INTO MICELLE AND VESICLE ENVIRONMENTS. Conner Campbell , Matthew Scheyer, Samuel Haralu, Fathima Dhilhani Moham -

med Faleel, Patrick Williams, Aliyah Wilson-Taylor, Sebastian Fonseca, Supriya Sapkota, Gary A. Lorigan, Indra D. Sahu 950-Pos Board B91 CHARACTERIZING THE DYNAMIC PROPERTIES OF KCNE3 IN LIPODISQ NANOPARTICLES USING EPR SPECTROSCOPY. Matthew Scheyer , Conner Campbell, Patrick Williams, Samuel Haralu, Aliyah Taylor, Isaac Asare, Mustakim Hussain, Afsana Begum, Payton Dabney, Nima Patel, William Carbo, Gary A. Lorigan, Indra D. Sahu Intrinsically Disordered Proteins II (Boards B92 - B116) 951-Pos Board B92 RECALIBRATING REPLICA EXCHANGE SOLUTE TEMPERING FOR SAMPLING DISORDERED PROTEIN CONFORMATIONS. Yumeng Zhang , Jianhan Chen 952-Pos Board B93 LOCATE REVEALS ELECTROSTATIC "ISLANDS" AND "HOTSPOTS" ARE IMPORTANT FOR A DISORDERED CLOCK PROTEIN'S INTERACTIONS TO REGULATE CLOCK ROBUSTNESS. Meaghan S. Jankowski , Daniel Griffith, Divya G. Shastry, Jacqueline F. Pelham, Joshua Thomas, Pankaj Karande, Alex S. Holehouse, Jennifer M. Hurley 953-Pos Board B94 HETEROGENEOUS DISTRIBUTIONS OF CHARGE STATES DETERMINE THE APPARENT NET CHARGE OF INTRINSICALLY DISORDERED PROTEINS. Ammon E. Posey , Martin J. Fossat, Rohit V. Pappu 954-Pos Board B95 STRUCTURE AND DYNAMICS OF AN INTRINSICALLY DISORDERED PROTEIN FROM SCATTERING, FRET AND ALL-ATOM SIMULATIONS. Robert B. Best 955-Pos Board B96 BIOPHYSICAL AND EVOLUTIONARY ANALYSIS OF HIV-1 VIF IN MOLECU - LAR DYNAMICS SIMULATIONS. Matthew Krzystyniak , Elizabeth Miller, Juan Alcantara, Aurelia Ball 956-Pos Board B97 BENCHMARKING MOLECULAR DYNAMICS FORCE FIELDS FOR SIMULA - TIONS OF BIOLOGICAL CONDENSATES. Kumar Sarthak , David N. Winogra - doff, Aleksei Aksimentiev 957-Pos Board B98 PROLINE ISOMERIZATION IN MOLECULAR DYNAMICS SIMULATIONS OF A PROLINE-RICH SIGNALING PEPTIDE. K. Aurelia Ball , Juan Alcantara, Elliott Board B99 ANALYSES OF EXPERIMENT BASED RAMACHANDRAN PLOTS OF TRI-, TET - RA- AND PENTAPEPTIDES REVEAL RESIDUE DEPENDENT INTERACTIONS BETWEEN NEIGHBORS. Reinhard Schweitzer-Stenner , Bridget Milorey 959-Pos Board B100 LOCAL INTERACTIONS AND TRANSIENT SECONDARY STRUCTURES GOVERN BACKBONE DYNAMICS OF INTRINSICALLY DISORDERED PRO - TEINS. Souvik Dey , MatthewMacAinsh, Huan-Xiang Zhou 960-Pos Board B101 LINKING DISORDERED PROTEIN SEQUENCE AND ENSEMBLE USING IN - TERACTION MAPS. Feng Yu , Shahar Sukenik 961-Pos Board B102 A BALANCE OF ATTRACTIVE AND REPULSIVE FORCES CONTROLS THE DIRECTION OF MEMBRANE BENDING BY INTRINSICALLY DISORDERED PROTEINS. Feng Yuan , Justin R. Houser, Arjun Sangani, Liping Wang, Eileen M. Lafer, Jeanne C. Stachowiak J. Stollar 958-Pos

M O N D A Y

74