Biophysical Society 66th Annual Meeting Program Guide

RNA Structure and Dynamics (Boards B131 - B152)

1005-Pos Board B146 CHARACTERIZATION OF THE S2M G15U MUTATION ASSOCIATED WITH THE SARS-COV-2 DELTA VARIANT. Caylee L. Cunningham , Caleb J. Frye, Joshua A. Imperatore, Kendy A. Pellegrene, Adam H. Kensinger, Joseph A. Makowski, Morgan Shine, Patrick Lackey, Jeffrey D. Evanseck, Mihaela- Rita Mihailescu 1006-Pos Board B147 STRUCTURAL AND DYNAMICAL IMPACT OF THE TWO-NUCLEOTIDE DIFFERENCE IN SEQUENCE BETWEEN SARS-COV AND SARS-COV-2 S2M USING MOLECULAR DYNAMICS. Adam H. Kensinger , Kendy A. Pellegrene, Joseph A. Makowski, Caylee L. Cunningham, Caleb J. Frye, Mihaela-Rita Mihailescu, Jeffrey D. Evanseck 1007-Pos Board B148 STEM-LOOP II MOTIF (S2M) STRUCTURAL AND DYNAMICAL DIFFER - ENCES BETWEEN SARS-COV-2 AND B.1.617.2 (DELTA) VARIANT. Joseph A. Makowski , Adam H. Kensinger, Kendy A. Pellegrene, Caylee Cunningham, Caleb J. Frye, Morgan Shine, Izayah Bojanac, Patrick Lackey, Mihaela-Rita Mihailescu, Jeffrey D. Evanseck 1008-Pos Board B149 RATIONALLY IDENTIFIED MICRORNAS AS NOVEL ENDOGENOUS TARGETS TO ENHANCE IMMUNOTHERAPY IN GLIOBLASTOMA MULTIFORME. Humza Irfan 1009-Pos Board B150 AN ONLINE DATABASE OF RNA-SMALL MOLECULES COMPLEXES FOR RATIONAL DRUG DESIGN. Francesco Paolo Panei , Paraskevi Gkeka, Mas - similiano Bonomi 1010-Pos Board B151 PROBING CONFORMATIONAL SUBPOPULATIONS OF RNA AND DNA USING FLUORESCENCE-DETECTED CIRCULAR DICHROISM SPECTROSCO - PY. Janson E. Hoeher , Christopher Vandermeer, Julia R. Widom 1011-Pos Board B152 Travel Award Winner FLUORESCENCE LIFETIME IMAGING MICROSCOPY (FLIM) FOR TRACK - ING RNA DYNAMICS IN LIVE MAMMALIAN CELLS. Nadia Sarfraz , Esther Braselmann Protein-Nucleic Acid Interactions I (Boards B153 - B180) 1012-Pos Board B153 INTERACTION BETWEEN DNA MISMATCH REPAIR PROTEINS AND TRIPLET REPEAT DNA OBSERVED FROM SINGLE-MOLECULE FRET MEASURE - MENTS. Pengning Xu , Keith Weninger 1013-Pos Board B154 STRUCTURAL MODELING AND MOLECULAR DYNAMICS SIMULATIONS OF SCMSH4-MSH5 REVEAL INSIGHT TO FUNCTION DURING MEIOTIC RECOMBINATION. Zane Lombardo , Bharat Lakhani, Manju M. Hingorani, David L. Beveridge, Ishita Mukerji 1014-Pos Board B155 MOLECULAR MECHANISM FOR CONFORMATIONAL ACTIVATION OF SARS- COV-2 RNA POLYMERASE BY NUCLEOSIDE TRIPHOSPHATE. Wen Ma , J. AndrewMcCammon 1015-Pos Board B156 Travel Award Winner A COARSE-GRAINED REPRESENTATION OF DNA IMMERSED IN AN EX - TERNAL PROTEIN FORCE-FIELD. Cecilia BOres , Oliver Henrich, Chuanying Chen, B. Montgomery Pettitt 1016-Pos Board B157 BINDING AND WRAPPING OF E. COLI SINGLE STRANDED BINDING PROTEIN (SSB) C-TERMINAL TAIL VARIANTS MEASURED USING FORCE SPECTROSCOPY. Gudfridur B. Moller , Michael Morse, M. Nabuan Naufer, James McIsaac, Ioulia F. Rouzina, Penny J. Beuning, Mark C. Williams

M O N D A Y

990-Pos Board B131 NANOMECHANICAL CROWDING AT THE INTERFACE BETWEEN RNA AND SOFT SURFACES. Horacio V. Guzman, Simón Poblete 991-Pos Board B132 RNA STRUCTURE PREDICTION WITH DIRECT COUPLING ANALYSIS. Christian Faber , Mehari Bayou Zerihun, Alexander H. Schug 992-Pos Board B133 LINKING FOLDING DYNAMICS AND FUNCTION OF SINGLE SAM/SAH RIBOSWITCH. Ting-Wei Liao , Lin Huang, Timothy J. Wilson, David M.J. Lilley, Taekjip Ha 993-Pos Board B134 SINGLE-MOLECULE INVESTIGATION OF COOPERATIVITY WITHIN THE GLYCINE TANDEM RIBOSWITHCH. Rosa A. Romero , Adrien Chauvier, Nils G. Walter 994-Pos Board B135 STRUCTURAL AND MECHANISTIC STUDY OF A PH-RESPONSIVE RIBO - SWITCH. Christine N. Stephen , Tatiana V. Mishanina 995-Pos Board B136 AN IN SILICO STUDY OF THE STRAND INVASION MECHANISM OF THE YXJA GUANINE RIBOSWITCH. Elise N. White , Naomi L. Brandt, Alan A. Chen 996-Pos Board B137 PRE-MRNA ALLOSTERY SERVES AS A STOCHASTIC SWITCH THAT SELECTS ALTERNATIVE SPLICE SITES. Robb S. Welty , Nils G. Walter 997-Pos Board B138 ENHANCED COMPACTION AND FOLDING OF RNAS IN APOLAR CHEMICAL ENVIRONMENTS. Shamal M. Gunawardhana, Erik D. Holmstrom 998-Pos Board B139 A HAIRPIN TO DUPLEX CONVERSION UNDERLIES RNA FOCI PHASE TRAN - SITIONS. Eitan S. Acks , Caitlin Davis 999-Pos Board B140 INVESTIGATING JAPANESE ENCEPHALITIS VIRUS LONG-RANGE TERMI - NAL REGION INTERACTIONS. Sean M. Park , Tyler Mrozowich, Michael T. Wolfinger, Trushar R. Patel 1000-Pos Board B141 DISSECTION OF STRUCTURAL HETEROGENEITY IN HUMAN TELOMERASE RNA. Nicholas Forino , Michael D. Stone 1001-Pos Board B142 RAPID INDUCIBLE DECAY OF RNA (RIDR) REVEALS ROLES OF PROCESSING BODIES. Lauren A. Blake , Yang Liu, Bin Wu 1002-Pos Board B143 ACTIVATION OF GΑQ SEQUESTERS SPECIFIC TRANSCRIPTS INTO AGO2 PARTICLES. Lela Jackson , Suzanne F. Scarlata 1003-Pos Board B144 MICRORNA-122 AND POLY-C BINDING PROTEIN 2 REGULATE HEPATITIS C REPLICATION BY BINDING TO OVERLAPPING SITES ON THE 5' UNTRANS - LATED REGION OF THE VIRAL GENOME. Seth D. Scott , Kyung H. Choi 1004-Pos Board B145 VIRAL-HOST RNA-RNA INTERACTIONS IN SARS-COV-2: STUDY OF MIR- 760-3P INTERACTIONS WITH THE GENOME 3'-UNTRANSLATED RE - GION. Caleb J. Frye , Caylee L. Cunningham, Kendy A. Pellegrene, Adam H. Kensinger, Joseph A. Makowski, Jeffrey D. Evanseck, Mihaela-Rita Mihailescu

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