Biophysical Society 66th Annual Meeting Program Guide

1822-Pos Board B280 INHIBITION OF NA + -K + ATPASE BY CARBONYLATION CAUSES SR CA 2+ OVERLOAD AND SPONTANEOUS SR CA 2+ RELEASE IN VENTRICULAR MYO - CYTES. Elisa Bovo, Jaroslava Seflova, Ivana Y. Kuo, Seth L. Robia, Aleksey V. Zima 1823-Pos Board B281 ABERRATIONS IN T CELL CALCIUM SIGNALING AND MITOCHONDRIAL FUNCTION PREDICT THE PRESENCE OF THE GAIN-OF-FUNCTION MUTA - TION IN THE RYANODINE RECEPTOR TYPE 1. Lukun Yang, Elena N. Ded - kova, Paul D. Allen, Mohsin S. Jafri, Alla F. Fomina 1824-Pos Board B282 OVEREXPRESSION OF MCU VS. MITO-ROS SCAVENGING TO ATTENUATE PROARRHYTHMIC SPONTANEOUS CA 2+ RELEASE IN DISEASED VENTRICU - LAR MYOCYTES. Shanna Hamilton , Radmila Terentyeva, Fruzsina Perger, Benjamín Hernández Orengo, Benjamin Martin, Matthew Gorr, Andriy E. Belevych, Richard T. Clements, Sandor Gyorke, Dmitry A. Terentyev 1825-Pos Board B283 FATTY ACIDS MEDIATE HEPATOCYTE CALCIUM RELEASE AND ER STRESS INDUCTION AFTER TRAUMATIC INJURY. Ying Fan , Marc Jeschke, Darren F. Board B284 CALCIUM BURSTS REGULATE ACTIN REORGANIZATION DURING NEU - TROPHIL PHAGOCYTIC SPREADING. Emmet A. Francis , Soichiro Yamada, Volkmar Heinrich 1827-Pos Board B285 ULTRASTRUCTURAL EFFECTS OF MODULATING CALCIUM HANDLING IN THE CARDIAC INTERCALATED DISC. Kathryn M. Hardin , James W. Smyth, Steven Poelzing, Gregory S. Hoeker 1828-Pos Board B286 USING RANDOMMATRIX THEORY TO UNDERSTAND SA-NODE CALCIUM SIGNALLING DATA. Anna Maltsev , Chloe Norris 1829-Pos Board B287 RED LIGHT-ABSORBING CONIJUGATED POLYMER OPTICALLY MODULATES CA 2+ DYNAMICS IN CARDIOMYOCYTES DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS. Carlotta Ronchi Boehning 1826-Pos 1830-Pos Board B288 CAMKII SIGNALLING IS REDUCED IN THE SINUS NODE OF A HEART FAIL - URE EXPERIMENTAL MODEL. Jianbin XUE, Almudena Val Blasco, Moran Davoodi, Susana Gomez, Yael Yaniv, Jean-Pierre Benitah, Ana M. Gomez 1831-Pos Board B289 INSIGHT INTO THE THERAPEUTIC POTENTIAL OF ENT- VERTICILIDE BASED ON DIRECT MEASURES OF RYR FUNCTION. Jacob A. Schwarz , Daniel Blackwell, Abigail N. Smith, Robyn T. Rebbeck, Jeffrey N. Johnston, Bjorn C. Knollmann, Razvan L. Cornea 1832-Pos Board B290 SEXUAL DIMORPHISM IN BIDIRECTIONAL CONTROL OF SR-MITOCHON - DRIA CROSSTALK IN VENTRICULAR CARDIOMYOCYTES. Radmila Terentyeva , Shanna Hamilton, Benjamin Y. Martin, Fruzsina Perger, Roland Veress, Andriy E. Belevych, Sandor Gyorke, Richard T. Clements, Dmitry A. Terentyev 1833-Pos Board B291 INITIATION OF CALCIUMWAVES IN FAILING CARDIAC MYOCYTES IS SENSI - TIVE TO POSTTRANSLATIONAL MODIFICATIONS. Daisuke Sato , Christo - pher Y. Ko, Donald M. Bers Intracellular Calcium Channels and Calcium Sparks and Waves (Boards B288 - B301)

1811-Pos Board B269 A MOLECULAR DYNAMICS EXPLORATION OF THE BINDING OF PHOSPHA - TIDYLINOSITOL-4,5-BISPHOSPHATE TO TRANSIENT RECEPTOR POTEN - TIAL CANONICAL 3. Amy V. Clarke , Oleksandra Tiapko, Klaus Groschner, Thomas Stockner Calcium Signaling (Boards B270 - B287) 1812-Pos Board B270 QUANTIFYING THE INTERACTIVE ARRHYTHMOGENIC EFFECTS OF CELL ULTRASTRUCTURAL REMODELING AND CALCIUM-HANDLING PROTEIN REDISTRIBUTION IN A THREE-DIMENSIONAL MODEL OF THE HUMAN ATRIAL MYOCYTE. Xianwei Zhang , Haibo Ni, Stefano Morotti, Charlotte Smith, Daisuke Sato, William E. Louch, Andrew G. Edwards, Eleonora Grandi 1813-Pos Board B271 ROLE OF MICU1 IN THE CONTROL OF THE CARDIAC MITOCHONDRIAL CALCIUM UNIPORTER. Prottoy Hasan , Macarena R. Prados, Elena V. Berezhnaya, Benjamín C. Saavedra, David B. Weaver, John Elrod, Gyorgy Board B272 USING REAL-TIME CA 2+ TRANSIENTS TO DRIVE "ELECTRONIC EXPRES - SION" OF CA 2+ -DEPENDENT K + CURRENTS USING DYNAMIC CLAMP. Brian K. Panama , Anthony Costantino, Mark W. Nowak, Randall L. Rasmusson, Glenna Bett 1815-Pos Board B273 ORAI CHANNEL GOF MUTANTS DEFINE CRITICAL FUNCTIONAL DISTINC - TIONS BETWEEN ORAI SUBTYPES. Michelle R. Jennette , James H. Bara - niak, Yandong Zhou, Donald L. Gill 1816-Pos Board B274 THE LIPID TRANSPORTER PROTEINS ORP5 AND ORP8 IN CA 2+ SIGNALING. Wooyoung Chung , Malini Ahuja, Beth A. McNally, Henry K.E. Ohman, Spencer Leibow, Shmuel Muallem 1817-Pos Board B275 ISOGENIC MODELS OF PARKINSON'S DISEASE AS A TOOL FOR STUDYING THE EFFECT OF MUTATION G2019S IN LRRK2 GENE ON CALCIUM SIGNAL - ING. Dmitry Grekhnyov , Vladimir Vigont, Elena Kaznacheyeva 1818-Pos Board B276 EXPANDING SIGNALING REPERTOIRE OF ANOCTAMIN 1 BY LOCALIZATION AT MEMBRANE CONTACT SITES. Weiyin Lin , Woo Young Chung, Malini Ahuja, Shmuel Muallem 1819-Pos Board B277 A KEY AMINO ACID IN STIM1 MEDIATES COUPLING TO GATE THE ORAI1 CHANNEL. Yandong Zhou , Robert M. Nwokonko, Guolin Ma, James H. Baraniak, Jian Wang, Michelle R. Jennette, Nikolay V. Dokholyan, Yun Huang, Donald L. Gill 1820-Pos Board B278 PROFIBROTIC STIMULI INDUCE COMPARTMENT-SPECIFIC REMODELING OF INTRACELLULAR CALCIUM HANDLING IN CARDIAC FIBROBLASTS. Andriy E. Belevych , Shanna Hamilton, Fruzsina Perger, Sandor Gyorke, Dmitry A. Terentyev 1821-Pos Board B279 CHARACTERIZATION OF CA 2+ HANDLING IN INDUCED-PLURIPOTENT CARDIOMYOCYTES FROM A CPVT FAMILY HARBOURING THE RYR2 R420Q MUTATION. Almudena Val Blasco , Liheng Yin, Pascale Gerbaud, Esther Zorio, Laurent David, Quentin Francheteau, Romain Perrier, Jean-Pierre Benitah, Ana M. Gomez Hajnoczky 1814-Pos

T U

E S

D A Y

116