Biophysical Society 66th Annual Meeting Program Guide

2306-Pos Board B136 OLIGOMERIC XPD HELICASE EXHIBITS ENHANCED UNWINDING ACTIVITY BY PUSHING IN UNSTABLE REGIONS OF DNA. Steve H. Yeo , Maria Spies, Yann Board B137 TARGETING G-QUADRUPLEX STRUCTURES WITH CAS9/DCAS9: CHALLENG - ES AND OPPORTUNITIES. Hamza Balci , Mohammed E. Hoque, Viktorija Globyte, GolamMustafa, Soumitra Basu, Chirlmin Joo 2308-Pos Board B138 DYNAMICS OF R-LOOP FORMATION BY CRISPR-CAS12F1 EFFECTOR COMPLEXES. Selgar Henkel-Heinecke , Greta Bigelyte, Tautvydas Karvelis, Virginijus Siksnys, Ralf Seidel 2309-Pos Board B139 Travel Award Winner MECHANISTIC STUDIES AND APPLICATION OF A TYPE-IIIA CRISPR-CAS SYS - TEM. Sagar Sridhara, Hemant N. Goswami , Jay Rai, Charlisa Whyms, Walter Woodside, Michael P. Terns, Jonathan H. Dennis, Hong Li 2310-Pos Board B140 CAS9 ACTIVITIES WITH TRUNCATED 16-NUCLEOTIDE RNA GUIDES ARE TUNED BY TARGET DUPLEX STABILITY BEYOND THE RNA/DNA HYBRID. Yue Li, Brendon Cooper, Yukang Liu, Difei Wu, Jiemin Zhao, Jing Lin, Xiaojiang Chen, Remo Rohs, Peter Z. Qin 2311-Pos Board B141 SINGLE-MOLECULE APPROACH TO STUDY GATE DYNAMICS OF MYCOBAC - TERIUM SMEGMATIS USING MAGNETIC TWEEZERS. Deepesh Sigdel , Dillon S. Balthrop, Chunfeng Mao, K. Maria Mills 2312-Pos Board B142 SITE-SEARCH PROCESS FOR SFII RESTRICTION ENZYME CHARACTERIZED BY TIME-LAPSE AFM. Sridhar Vemulapalli 2313-Pos Board B143 IMAGING THE INFECTIOUS CYCLE OF T7 AT THE SINGLE HOST-CELL LEVEL. Balint Kiss , Balázs Kretzer, Levente Herenyi, Hedvig Tordai, Miklós S. Kellermayer 2314-Pos Board B144 Travel Award Winner THE DISCOVERY OF ANTIVIRALS AND NOVEL TARGETS FOR SARS-COV-2 AND EV-A71. Christina Haddad , Blanton S. Tolbert, Amanda E. Hargrove, Gary Brewer, Mei-Ling Li 2315-Pos Board B145 IMPACTS OF MUTATIONS ON ELECTROSTATIC INTERACTIONS IN THE LAC REPRESSOR HEADPIECE. Skylar Ackerman , Daniel A. Barr 2316-Pos Board B146 HALOGEN BONDING: A NEWMECHANISM FOR ENZYME CATALYSIS. Pui S. Ho 2317-Pos Board B147 PROBING MECHANICAL AND THERMODYNAMIC PROPERTIES OF VIBRIO CHOLERAE TOXT BINDING TO DNA BY MOLECULAR DYNAMICS SIMULA - TIONS. Andreas Hanke , Shams Mehdi, Rim Touhami, Ahmed Touhami 2318-Pos Board B148 MEASURING DNA TARGET SEARCH AT THE SINGLE MOLECULE LEVEL. Van T. Nguyen , Emma E. Stevens, Allen C. Price 2319-Pos Board B149 HUMANIZATION AND CHARACTERIZATION OF THE S. CEREVISIAE SPLICING FACTOR PRP8 FOR DRUG SCREENING. Alana Caldwell , Aaron A. Hoskins 2320-Pos Board B150 ENGINEERING SEQUENCE SPECIFICITY IN AN RNA-BINDING ZINC FINGER PROTEIN. Qishan Liang , Joy S. Xiang, Kevin D. Corbett, Gene Yeo R. Chemla 2307-Pos

2321-Pos Board B151 REPRESENTATIVE CANCER-ASSOCIATED U2AF2 MUTATIONS OCCUR - RING AT THE INTER-RRM INTERFACE ALTER RNA INTERACTIONS AND SPLICING. Emily G. Butler , Debanjana Maji, Mary J. Pulvino, Jermaine L. Jenkins, Clara L. Kielkopf 2322-Pos Board B152 SEQUENCE SPECIFICITY IN DNA BINDING IS MAINLY DETERMINED BY ASSOCIATION RATHER THAN DISSOCIATION. Emil Marklund , Guanzhong Mao, Jinwen Yuan, Spartak Zikrin, Eldar Abdurakhmanov, Sebastian Deindl, Johan Elf 2323-Pos Board B153 THE BINDING SPECIFICITY OF BZIP/DNA FROM A KNOB-SOCKET ANALY - SIS. Aaron H. Tran , Hyun Joo, Jerry Tsai 2324-Pos Board B154 SINGLE RESIDUE SUBSTITUTION WITHIN THE COILED COIL DOMAIN OF L1-ORF1P ABOLISHES RETROTRANSPOSITION BY DISRUPTING NUCLEIC- ACID MEDIATED OLIGOMERIZATION. Benjamin Cashen , Nabuan Naufer, Michael Morse, Charlie E. Jones, Anthony Furano, Mark C. Williams 2325-Pos Board B155 SIMULATING STRUCTURAL TRANSITIONS DURING PROTEIN-DNA RECOG - NITION. Malin Lüking 2326-Pos Board B156 FUNCTIONAL ACTIVITY CHANGES IN PARB PROTEIN BY A KCK-TAG. Miranda L. Molina 2327-Pos Board B157 INFORMATION THEORY EMPOWERS DE NOVO DISCOVERY OF STRUC - TURAL MOTIFS UNDERPINNING PROTEIN-DNA INTERACTIONS. Jeremy W. Schroeder , Michael B. Wolfe, Peter L. Freddolino 2328-Pos Board B158 GLOBAL INFERENCE OF DNA-PROTEIN BINDING MOTIFS REVERSIBLE JUMP HAMILTONIAN MONTE CARLO. Ali M. Farhat , Peter L. Freddolino 2329-Pos Board B159 SINGLE-MOLECULE RNA REMODELLING BY THE DEXH-BOX 34 HELI - CASE. Paul Poudevigne-Durance , Nele Hug, Ann Mukhortava, Javier Caceres, David S. Rueda 2330-Pos Board B160 MECHANISM OF SELECTIVE RNA PACKAGING DURING HIV-1 PARTICLE ASSEMBLY. Silver Jõemetsa , Anne X. Zhou, Raymond F. Pauszek, Arishma R. Singh, Jonathan Kitzrow, Karin Musier-Forsyth, David P. Millar 2331-Pos Board B161 HIGH-THROUGHPUT FUNCTIONAL ASSAYS OF MAX MUTATIONS REVEAL HETERODIMERIZATION AND DNA-BINDING PREFERENCES. Renee Hastings , Arjun Aditham, Polly Fordyce Membrane Physical Chemistry II (Boards B162 - B177) 2332-Pos Board B162 CHARACTERIZING THE PROPERTIES OF A MIXED LIPID-DETERGENT SYS - TEM: IMPLICATIONS FOR MEMBRANE PROTEIN STUDIES. Monica D. Rieth 2333-Pos Board B163 INVESTIGATING THE ROLE OF SURFACTANT CHARGE IN THE INTERACTION OF PLANT POLYPHENOL MAMMEIGIN WITH MICELLES USING UV-VIS SPECTROSCOPY. Sanjana Senthilkumar , Latha Rangan, Rajaram Swami - nathan

W E

D N

E S

D A Y

140