Biophysical Society 66th Annual Meeting Program Guide

517-Pos Board B341 CONDUCTION DIFFERENCES BETWEEN ATRIAL AND VENTRICULAR WORKING MYOCARDIUM ELUCIDATED THROUGH PREVIOUSLY UNREC - OGNIZED NANOSCALE STRUCTURAL ORGANIZATION. Heather L. Struckman , Nicolae Moise, Izabella Dunlap, Zhenhui Chen, Seth H. Wein - berg, Rengasayee Veeraraghavan 518-Pos Board B342 MAVACAMTEN DEPRESSES HUMAN ATRIAL CONTRACTILITY IN THE SAME EC50% RANGE AS HUMAN VENTRICLE. Cecilia Ferrantini , Beatrice Scellini, Giulia Vitale, J. Manuel Pioner, Silvia Querceto, Raffaele Coppini, Nicoletta Piroddi, Corrado Poggesi, Chiara Tesi 519-Pos Board B343 CARDIAC MYOSIN VELOCITY AND FORCE ARE DRAMATICALLY IMPROVED WITH AN ALTERNATIVE TRIPHOSPHATE SUBSTRATE. Mike K. Woodward , Christopher Marang, Eric Ostrander, Brent Scott, Dhandapani Venkatara - man, Edward P. Debold 520-Pos Board B344 DEOXY -ATP -MEDIATED IMPROVEMENT OF CARDIOMYOCYTE ENERGET - ICS AND METABOLISM ACCOMPANY ENHANCED CONTRACTILITY. Ketaki N. Mhatre 521-Pos Board B345 EFFECTS OF MAVACAMTEN AND SARCOMERE LENGTH ON THE CA 2+ -SEN - SITIVITY OF PERMEABILIZED MYOCARDIAL STRIPS FROM PATIENTS WITH HEART FAILURE. Bertrand C.W. Tanner , Peter O. Awinda, Yemeserach Bishaw, Marissa Watanabe, Katherine L. Thompson, Mindy S. Thompson, Emma J. Birks, Kenneth S. Campbell 522-Pos Board B346 THICK AND THIN FILAMENT EFFECTORS OF CARDIAC MYOFIBRIL CON - TRACTION DETECTED IN A TROPONIN C-BASED HIGH-THROUGHPUT FLUORESCENCE LIFETIME ASSAY. Alexey V. Dvornikov , Thomas A. Bunch, Victoria C. Lepak, Brett A. Colson 523-Pos Board B347 THE MECHANISM OF CARDIAC THIN FILAMENT INHIBITION: THE PRECI - SION OF W7. Fangze Cai , Thomas Kampourakis, Kieran T. Cockburn, Brian Board B348 DCM AND HCMMUTATIONS TO Tpm1 DIFFERENTIALLY ALTER CONTRAC - TILE BEHAVIOR AND GENE EXPRESSION PROFILES IN ENGINEERED HEART TISSUES. Saiti S. Halder , Lorenzo R. Sewanan, Xia Li, Stuart G. Campbell 525-Pos Board B349 MODELING FORCE REDEVELOpmENT AS A RESPONSE TO THIN FILAMENT ACTIVATION TIME. Henry G. Zot , Prescott B. Chase, Javier E. Hasbun, J. Renato D. Pinto 526-Pos Board B350 THE ACTC A331P HYPERTROPHIC CARDIOMYOPATHY MUTATION EN - HANCES BASAL CONTRACTILE ACTIVITY AND CAUSES RESTING MUSCLE DYSFUNCTION. Matthew Doran, Evan Despond, Meera Viswanathan, Aditi Madan, Jennifer Cossentino, Michael J. Rynkiewicz, Duncan Sousa, William Lehman, John Dawson, Anthony Cammarato 527-Pos Board B351 STRUCTURE AND STRENGTH OF HUMAN CARDIAC MYOSIN S1-S2 INTER - ACTION. Alexandra N. Hurst , Yuri Nesmelov 528-Pos Board B352 A HOMOZYGOUS MISSENSE MUTATION IN THE M-DOMAIN OF CAR - DIAC MYOSIN BINDING PROTEIN-C IS LETHAL IN A CRISPR-GENE EDITED MOUSE MODEL. Rachel Sadler , Joshua Strom, Julie Fan, Samantha P. Harris D. Sykes 524-Pos

529-Pos Board B353 ELUCIDATING THE STRUCTURAL INTERACTION BETWEEN THE C-TERMI - NAL TAIL OF CARDIAC TROPONIN T AND THE TROPONIN CORE. Garrett Crosby , Jil C. Tardiff 530-Pos Board B354 PRIOR FREEZING HAS MINIMAL IMPACT ON THE CONTRACTILE PROP - ERTIES OF PERMEABILIZED HUMAN MYOCARDIUM. Gregory Milburn, Faruk H. Moonschi, Ashley M. White , Mindy Thompson, Emma J. Birks, Kenneth S. Campbell 531-Pos Board B355 MECHANISMS OF CONTRACTILE DYSFUNCTION FOR THE HYPERTROPHIC CARDIOMYOPATHY MYH7 G256E MUTATION STUDIED USING CRISPR- EDITED HIPSC-CMS. Kerry Y. Kao , Matthew C. Childers, Saffie Mohran, Michael Regnier 532-Pos Board B356 INVESTIGATING THE EFFECTS OF MUTATIONS WITHIN THE COILED-COIL TAIL OF CARDIAC AND SKELETAL MYOSIN. Glenn S.P. Carrington , Francine Parker, Marta Giralt-Pujol, Michelle Peckham Actin Structure, Dynamics, and Associated Proteins (Boards B357 - B369) 533-Pos Board B357 AN EXCITABLE SYSTEMS FRAMEWORK FOR CONTROL OF CELLS. Wolfgang Losert 534-Pos Board B358 DELETION OF CALPONIN 2 IMPAIRS PRIMORDIAL FOLLICLE FORMATION AND CAUSES EARLY EXHAUSION OF OVARIAN FOLLICLES IN MICE. Tzu- Bou Hsieh , J.-p. Jin 535-Pos Board B359 A NEMALINE MYOPATHY-LINKED POINT MUTATION DESTABILIZES THE SECOND ACTIN BINDING SITE OF TROPOMODULIN FAMILY PRO - TEINS. Garry E. Smith , Lauren E. Schultz, Mert Colpan, Carol C. Gregorio, Alla S. Kostyukova 536-Pos Board B360 STRUCTURAL EFFECTS OF DISEASE RELATED MUTATIONS IN ACTIN BIND - ING PERIOD 3 OF TROPOMYOSIN. Balaganesh Kuruba , Marta Kaczmarek, Malgorzata K. Brodacka, Magdalena Fojutowska, Malgorzata Sliwinska, Alla S. Kostyukova, Joanna Moraczewska 537-Pos Board B361 CELL ADHESION UPREGULATES THE CORTICAL TENSION AND ACTIN COR - TEX THICKNESS DURING THE ADHESION PROCESS. Seyedsajad Moazzeni , Rick I. Cohen, David I. Shreiber, Jeffrey Zahn, Zheng Shi, Hao Lin 538-Pos Board B362 STRUCTURAL MECHANISM FOR BI-DIRECTIONAL ACTIN CROSSLINKING BY HUMAN T-PLASTIN. Lin Mei , Matthew J. Reynolds, Damien Garbett, Tobias Meyer, Gregory M. Alushin 539-Pos Board B363 THE MEMBRANE-CORTEX CROSSLINKER EZRIN ACTS AS A SLIDING AN - CHOR ON F-ACTIN. Elgin Korkmazhan , Alexander R. Dunn 540-Pos Board B364 REGULATION OF F-ACTIN SIZE HETEROGENEITY BY FORMIN AND CAP - PING PROTEINS. Deb S. Banerjee , Banerjee Shiladitya 541-Pos Board B365 ELECTRODEFORMABILITY OF GIANT UNILAMELLAR VESICLES DE - PENDS ON LUMENAL VISCOSITY AND ORGANIZATION OF ACTIN NET - WORKS. Nadab Wubshet

F R I D A Y

S U N D A Y

41