Biophysical Society 66th Annual Meeting Program Guide

Board S56 TOPOLOGICAL APPROACH FOR SEQUENCE-INDEPENDENT PROTEIN STRUC - TURE ALIGNMENT. Wai Shing Tang (650-Pos / B474) Board S57 NOVEL SEQUENCE SPACE EXPLORED BY FUNCTIONAL PROTEINS GENER - ATED THROUGH COMPUTATIONAL EVOLUTION-BASED DESIGN. Sophia Alvarez (215-Pos / B39) Board S58 OPTIMIZATION OF HYDRATION SITES IN PLANT HORMONE RECEPTORS FOR AGROCHEMICAL DESIGN. Diego E. Kleiman (921-Pos / B62) Board S59 MOLECULAR DYNAMICS SIMULATIONS REVEAL THAT ACETYLATION OF CATALYTIC LYSINE BALANCES ENTHALPIC DESTABILIZATION WITH ENTROPIC STABILIZATION TO PRESERVE ATP BINDING AFFINITIES IN CDK1. Krishna Kant Vishwakarma (910-Pos / B51)

Board S44 LOCATE REVEALS ELECTROSTATIC "ISLANDS" AND "HOTSPOTS" ARE IMPORTANT FOR A DISORDERED CLOCK PROTEIN'S INTERACTIONS TO REGULATE CLOCK ROBUSTNESS. Meaghan S. Jankowski (952-Pos / B93) Board S45 DOMAIN CAMOFLOUGE OF C-SRC: SEGMENTAL LABELING HIGHLIGHTS ONCOPROTEIN DOMAINS FOR NEUTRON SCATTERING. Viswanathan Gurumoorthy (278-Pos / B102) Board S46 SIMULTANEOUS FRACTIONATION AND CHARACTERISATION OF PRE-FI - BRILLAR AGGREGATES IN SOLUTION WITH SINGLE-MOLECULE MICRO - FLUIDICS. Ewa A. Andrzejewska (1712-Pos / B170) Board S47 LINKING DISORDERED PROTEIN SEQUENCE AND ENSEMBLE USING INTERACTION MAPS. Feng Yu (960-Pos / B101) Board S48 LOCAL INTERACTIONS AND TRANSIENT SECONDARY STRUCTURES GOV - ERN BACKBONE DYNAMICS OF INTRINSICALLY DISORDERED PROTEINS. Souvik Dey (959-Pos / B100) Board S49 REAKAGE DEPENDENT AMYLOID GROWTH KINETICS: A COMPUTATION - AL STUDY. Jennifer Joseph (1703-Pos / B161) Board S50 BIOMECHANICS AND MOLECULAR MECHANISMS OF AGING IN ELASTIN. Chengeng Yang (252-Pos / B76) Board S51 PROBING THE ROLE OF NON-SPECIFIC INTERACTIONS IN PROMOTING FUNCTIONAL PROTEIN-PROTEIN COMPLEXES. Rakesh K (2545-Pos / B375) Macromolecular Machines and Assemblies (Boards S52–S59) Board S52 HETEROGENOUS STRUCTURES AND PHASE SEPARATIONS IN GIANT VESICLE PREPARATIONS. Akanksha Chauhan (349-Pos / B173) Board S53 HYDRATION-WATER AND MEMBRANE LIPIDS MODULATE G-PROTEIN- COUPLED RECEPTOR ACTIVATION. Nipuna Weerasinghe (2211-Pos / B41) Board S54 A DISORDERED LINKER WITH "SOMETHING" ON ITS N-TERMINUS DRIVES THE ALLOSTERY IN THE UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA). Constanza Torres-Paris (1620-Pos / B78) Board S55 CATALYTIC FUNCTION AND SUBSTRATE SPECIFICITYOF ALPHA AND BETA CORONAVIRUS PAPAIN-LIKE PROTEASES: TARGETING HUMAN NL63, SARS-COV AND SARS-COV-2 (COVID-19) WITH DESIGNED INHIBITORS. Mackenzie E. Chapman (929-Pos / B70)

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Mechanobiology (Boards S60–S68)

Board S60 HSV-1 IMMEDIATE EARLY PROTEINS CHANGE BIOPHYSICAL PROPERTIES OF

THE INFECTED CELL NUCLEUS. Nora L. Herzog (2397-Pos / B227) Board S61

HYPERTROPHIC AND DILATED CARDIOMYOPATHY-ASSOCIATED TNNT2 PATHOGENIC VARIANTS INDUCE NUCLEUS REMODELING IN HIPSC-CM MODELS. Isabella Leite Coscarella (1925-Pos / B383) Board S62 SLIDING HYDROGELS ENHANCE MSC CHONDROGENESIS BY FACILITATING EARLY STAGE CYTOSKELETAL/NUCLEAR DYNAMICS AND MECHANICAL LOADING. Manish Ayushman (1282-Pos / B423) Board S63 ROLE OF CARDIAC ALPHA-ACTININ 2 PATHOGENIC VARIANT IN HUMAN MYOCARDIUMMECHANICS. Michelle C. Rodriguez Garcia (1927-Pos / B385) Board S64 PSEUDO-KNOT-LIKE DNA TENSION PROBE SHOWS THAT CELL ADHESION RECEPTORS DETECT THE MOLECULAR FORCE-EXTENSION CURVE OF THEIR LIGANDS. Rachel L. Bender (574-Pos / B398) Board S65 PRELOAD-INDUCED CARDIOMYOCYTE CALCIUM OVERLOAD AND VEN - TRICULAR DAMAGE IN ISOLATED HEARTS FROM YOUNG DUCHENNE MUSCULAR DYSTROPHY (DMD MDX-4CV ) MICE. Vivian Onyali (1141-Pos / B282) Board S66 CHARACTERIZING THE LIPID FINGERPRINT OF THE MECHANOSENSITIVE CHANNEL PIEZO2. Yie Chang Lin (1794-Pos / B252) Board S67 - withdrawn

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