Biophysical Society 67th Annual Meeting Program Guide

Platform Mitochondria, Endoplasmic Reticulum and Bioenergetics 8:15 am - 10:15 am, Room 5AB

1475-Plat 8:45 am THE FACTORS THAT DETERMINE THE FORCE NEEDED TO UNFOLD A MEM BRANE PROTEIN IN SILICO DEPEND ON THE PULLING DIRECTION. Nabil F. Faruk , Xiangda Peng, Tobin R. Sosnick 1476-Plat 9:00 am RATIOMETRIC SENSING OF REDOX ENVIRONMENTS INSIDE INDIVIDUAL CARBOXYSOMES TRAPPED IN SOLUTION. William B. Carpenter , Abhijit A. Lavania, Julia B. Turnšek, Davis Perez, Luke M. Oltrogge, Peter D. Dahl berg, David F. Savage, William E. Moerner 1477-Plat 9:15 am REACTMIN: REACTIVE SCANNING BASED SINGLE PARTICLE TRACKING US ING A MINIMUM OF LIGHT. Nicholas A. Vickers, Sean B. Andersson 1478-Plat 9:30 am UNPICKING DNA TRANSLOCATION IN NANOPORES WITH SIMULTANE OUS SINGLE-MOLECULE FLUORESCENCE AND OPTICAL SINGLE CHANNEL RECORDING. Daisy Rogers-Simmonds, Steven Vanuytsel, Mark I. Wallace 1479-Plat 9:45 am ENABLING MULTIPERSPECTIVE SINGLE-MOLECULE FRET. Roman Kiselev , Arnab Modak, Daniel Terry, Alessandro Borgia, Roger Altman, Scott C. 10:00 am HIGH THROUGHPUT SINGLE-MOLECULE TECHNOLOGY. Sung Hyun Kim , Ivo Severins, Frank Brandenburg, Carolien Bastiaanssen, Chirlmin Joo Subgroup Chairs Meeting 9:00 am - 11:00 am, Room 17B Career Development Center Workshop Demystifying the Academic Job Search II: Preparing your Written Application Materials 9:30 am - 10:30 am, Room 16B Over 90% of the cuts in a typical academic job search are made on the basis of your written application materials. Given the large number of candidates in a typical applicant pool, your documents must convey the most important information about you in the most clear and efficient manner. Learn about how your materials should differ based on the type of institution and/or program, and how to create “glance-able” docu ments to speak most effectively on your behalf. Exhibitor Presentation Bruker 9:30 am - 11:00 am, Room 9 Single-Molecule Localization Microscopy for Advanced Biological and Genomic Imaging in Three Dimensions: The Bruker Vutara VXL Most sub-cellular structures are smaller than 300 nm, beyond the opti cal resolution limit for fluorescence microscopy. The single-molecule localization microscope (SMLM) Bruker Vutara VXL overcomes this limitation. With an optical resolution of 20 nm, SMLM is uniquely quali fied to address biological mysteries that require specific labeling as used in fluorescence microscopy but higher resolution than can be achieved with diffraction-limited microscopy. In addition to SMLM, the Vutara VXL implements imaging workflows for multiplexed chromatin tracing and smFISH applications. The system images, resolves, and quantifies cellular structures, molecular machines, proteins, RNA, and chromosomal structures. SMLMmodulates the emission from dye molecules to prevent their point-spread-function (PSF) spatial overlap. Advanced fitting algorithms localize the position of each dye molecule with a resolution well below the optical resolution limit. The proprietary bi-plane technology of the Bruker Vutara VXL extends the traditional 2D fitting into the third dimen - Blanchard 1480-Plat

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Co-Chairs Nelli Mnatsakanyan, Penn State University, USA Ildikò Szabò, University of Padova, Italy 1465-Plat 8:15 am

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LIVING ON HYDRAZINE: METABOLIC PROTEIN COMPLEXES FROM AN ANAEROBIC AM MONIUM OXIDIZER. Lea Dietrich, Tadeo Moreno Chicano, Naomi M. Almeida, Mohd Akram, Mike Jetten, Laura van Niftrik, Andreas Dietl, Boran Kartal, Thomas R.M. Barends, Kristian Parey 1466-Plat 8:30 am Travel Award Winner DISORDERED REGIONS OF RESPIRATORY SUPERCOMPLEXES OFFER NEW PATHWAYS FOR SUBSTRATE CHANNELING IN CROWDED MEMBRANES. Chun Kit Chan , Jonathan T. Nguyen, Chitrak Gupta, Alberto Perez, Eugenia Mileykovskaya, Emad Tajkhorshid, Abhishek Singharoy 1467-Plat 8:45 am ATP SYNTHASE C-SUBUNIT LEAK CHANNEL AS A NOVEL THERAPEUTIC TAR GET. Amrendra Kumar, Daniel Morris, Yangyu Wu, Emma Amjad, Han-A Park, Nelli Mnatsakanyan 1468-Plat 9:00 am A NOVEL THERAPEUTIC STRATEGY AGAINST MITOCHONDRIAL RESPIRA TORY CHAIN DYSFUNCTION-LINKED DISEASES. Daniele Bonesso, Andrea Mattarei, Roberta Peruzzo, Marta Favero, Andrea Rossa, Massimo Zeviani, Carlo Viscomi, Ildikò Szabò 1469-Plat 9:15 am CAUSES AND CONSEQUENCES OF SUCCINATE ACCUMULATION DURING CARDIAC ISCHEMIA. Nicole L. Collins , Françoise Van den Bergh, Daniel A. Beard 1470-Plat 9:30 am 4D MITOCHONDRIAL BIOPHYSICAL PARAMETERS PREDICT CELL TYPE IN HUMAN ORGANOID TISSUE. Gillian McMahon , McKenna Rude, Challana Tea, Zichen Wang, Parth Natekar, Hiroyuki Hakozaki, Johannes Schöneberg 1471-Plat 9:45 am CRYOEM OF OPA1 HELICAL STRUCTURES GIVES PERSPECTIVE TO MITO CHONDRIAL DYSFUNCTION. Sarah B. Nyenhuis , Xufeng S. Wu, Abigail Stanton, Marie-Paule Strub, Yang-In Yim, Bertram J. Canagarajah, Jenny E. Hinshaw 1472-Plat 10:00 am WANDERING THE INTRACELLULAR MAZE. Zubenelgenubi C. Scott , Laura M. Westrate, Elena F. Koslover Platform Single-Molecule Spectroscopy 8:15 am - 10:15 am, Room 11AB Co-Chairs William Carpenter, Stanford University, USA Mark Wallace, King’s College London, United Kingdom 8:15 am FLUORESCENT PROTEINS FOR FLUCTUATION SPECTROSCOPY IN VIVO . Falk Schneider , Le A. Trinh, Scott E. Fraser 1474-Plat 8:30 am TOWARDS A NEWMODULAR POLYPROTEIN SYSTEM COMPATIBLE WITH SINGLE-MOLECULE FORCE SPECTROSCOPY BY ATOMIC FORCE MICROS COPY AND MAGNETIC TWEEZERS. Diana Velázquez-Carreras , Manuel Gavilan-Herrera, Ines Martinez-Martin, Carmen Suay-Corredera, Andra C. Dumitru, Elías Herrero Galán, Jorge Alegre-Cebollada 1473-Plat

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