Biophysical Society 67th Annual Meeting Program Guide

Protein Structure and Conformation III (Boards B1 - B35) 1596-Pos Board B1 ELUCIDATING THE ORIGINS OF ACYLTRANSFERASE SELECTIVITY IN PRI MARY AND SECONDARY METABOLISM. Ashay Patel , Jeffrey T. Mindrebo, Laetitia E. Misson, James A. McCammon, Joseph P. Noel, Michael D. Burkart 1597-Pos Board B2 INSULIN MODULATES THE FREE ENERGY LANDSCAPE OF INSULIN DEGRADING ENZYME AS IT TRANSITIONS BETWEEN CLOSED AND OPEN STATES. Mukerrem Tufekcioglu , David Tang, Esmael J. Haddadian 1598-Pos Board B3 BIOPHYSICAL CHARACTERIZATION OF RAF RBD-CRD-KD INTERACTIONS IN THE AUTOINHIBITED STATE. Baasit Jamal , Ruihan Quan, Maria Iannucci, Zhenlu Li, Chinmayi Prasanna, Amita R. Sahoo, Matthias Buck 1599-Pos Board B4 TIME-RESOLVED MECHANISMS OF ESSENTIAL BIOLOGICAL PATH WAYS. Sharonda LeBlanc , Andi Morgan, Ashley Drew, Kenya Gordon, Meredith Frazier, Andrew Atisa, Malikiya A. Hinds, Robin Stanley 1600-Pos Board B5 APPLICATION OF IN-CELL FAST PHOTOCHEMICAL OXIDATION OF PRO TEINS (IC-FPOP) FOR THE STUDY OF ORGANOIDS. Raquel L. Shortt , Lisa Board B6 LIGAND BINDING AND PH INFLUENCE CONFORMATIONAL FLEXIBILITY OF DOMAINS I AND III IN BOVINE SERUM ALBUMIN. Garry E. Smith , viana nguyen, Adam Okerlund, Christopher D. Warner 1602-Pos Board B7 DEFINING THE ROLE OF THE N-TERMINAL HELIX IN THE ARF1 NUCLEO TIDE SWITCH TRANSITION USING PRESSURE PERTURBATION. Edgar Peters , Tejaswi Naidu Koduru, Noam Hantman, Jacqueline Cherfils, Scott A. McCallum, Richard E. Gillilan, Catherine A. Royer 1603-Pos Board B8 Travel Award Winner ELUCIDATION OF A DYNAMIC INTERPLAY BETWEEN GUANINE NUCLEO TIDE AND THE TERNARY COMPLEX OF A BETA-ADRENERGIC RECEPTOR, ITS AGONIST AND STIMULATORY G PROTEIN. Yanxiao Han , John R.D. Dawson, Kevin DeMarco, Kyle Rouen, Khoa Ngo, Borislava Bekker, Vladi mir Yarov-Yarovoy, Colleen E. Clancy, Yang K. Xiang, Igor V. Vorobyov 1604-Pos Board B9 SINGLE-MOLECULE SPECTROSCOPY OF APOLIPOPROTEIN E REVEALS A COMPLEX CONFORMATIONAL ENSEMBLE. Melissa D. Stuchell-Brereton , Maxwell I. Zimmerman, Justin J. Miller, Upasana L. Mallimadugula, Juan J. Incicco, Debjit Roy, Louis G. Smith, Jasmine Cubuk, Berevan Baban, Gregory T. DeKoster, Carl Frieden, Gregory R. Bowman, Andrea Soranno 1605-Pos Board B10 STRUCTURAL BASIS FOR THE MOLECULAR RECOGNITION OF VARI OUS RGD-CONTAINING LIGANDS BY INTEGRIN ΑVΒ3: THE ROLE OF THE SPECIFICITY-DETERMINING LOOP (SDL). Ramya Chandar Charles Maria Soosai , Santanu Bose, Senthil Natesan 1606-Pos Board B11 A SCALE-SPANNING INTEGRATIVE MODELING STRATEGY TO STUDY STRUCTURE, DYNAMICS, AND FUNCTION OF VITAL MOLECULAR MA CHINES. Till Rudack 1607-Pos Board B12 CHARACTERIZING THE APOBEC3B CLOSED TO OPEN PATHWAY WITH WEIGHTED ENSEMBLE. Clare K. Morris M. Jones 1601-Pos

1608-Pos Board B13 BIOPHYSICAL CHARACTERIZATION OF PATHOGENIC MISSENSE MUTATION IN THE ARID DOMAIN OF ARID1A. Rajen K. Goutam , Emil Alexov, William J. Edenfield, Hugo Sanabria 1609-Pos Board B14 HDX-MS GUIDED ENSEMBLE REWEIGHTING APPROACH REVEALS CRYPTIC DRUG BINDING SITES IN THE CYTOPLASMIC HEME BINDING PROTEIN, PHUS. Kyle C. Kihn , Nicholas Montes, Kellie Hom, Wenbo Yu, Fengtian Xue, Alexander D. MacKerell, Angela Wilks, Daniel Deredge 1610-Pos Board B15 UNEXPECTED, PERVASIVE, CONSERVED SECONDARY STRUCTURE IN HIGHLY CHARGED PROTEIN REGIONS. Catherine Triandafillou , Rosalind Pan, David A. Drummond, Aaron Dinner 1611-Pos Board B16 EPITOPE MAPPING OF DIAGNOSTIC ANTI-RABIES MONOCLONAL ANTI BODIES PROVIDE STRUCTURAL INSIGHT INTO RABIES VARIANT IDENTIFI CATION IN INFECTED WILDLIFE. Megan Luo , Sophie Shoemaker, John E. Pak, Susan Marqusee 1612-Pos Board B17 INVESTIGATING DNASE1L3’S ROLE IN INFLAMMATION AND REDESIGNING THE ENZYME TO BE USED AS A THERAPEUTIC. Johanna Villarreal , Jon J. McCord, Minal Engavale, Elliot Radovan, Peter Keyel, Roger B. Sutton 1613-Pos Board B18 5’ADENOSINE MONOPHOSPHATE PROMOTES SIGNAL ADAPTATION IN PKA SIGNALING. Varun Venkatakrishnan , Ganesh S. Anand 1614-Pos Board B19 INVESTIGATING THE IMPACT OF ATPASE MUTATION ON MUTL FUNC TION. Ashley Drew , Andi Morgan, Sharonda LeBlanc 1615-Pos Board B20 SOLUTION SCATTERING AND SCANNING BASED IMAGING AT THE LIFE SCIENCES X-RAY SCATTERING BEAMLINE (LIX). Shirish N. Chodankar 1616-Pos Board B21 GOOD FENCES MAKE DISTANT NEIGHBORS: DETERMINING THE EFFECT OF LOCAL SEQUENCE CONTEXT ON MET-MET INTERACTIONS. Connor Pitman , Anthony Geneva, Matthew Hansen, Grace H. Brannigan 1617-Pos Board B22 STRUCTURE STUDY REVEALS ACTIVE AND INACTIVE CONFORMATIONS OF PROTEIN KINASE C B1. Anh T.Q. Cong , Taylor L. Witter, Bruinsma S. Elizabeth, Swaathi Jayaraman, Maria Dugan, John R. Hawse, Matthew P. Goetz, Matthew J. Schellenberg 1618-Pos Board B23 Travel Award Winner EFFECT OF NANOPARTICLES ON THE AGGREGATION AND AMYLOID FORMATION OF AMYLOID-BETA PEPTIDE. Éva Moussong , Márton Péter Nyiri, Nikoletta Murvai, Judit Kun, Attila Kovács, Tamás Molnár, András Micsonai, Jozsef Kardos 1619-Pos Board B24 INTERACTIONS OF LI + ION WITH NCS1: A POTENTIAL MECHANISM OF LI + NEUROPROTECTIVE ACTION AGAINST PSYCHOTIC DISORDERS. Md. Shofiul Alam , Jaroslava Miksovska 1620-Pos Board B25 MODELING BINDING PLASTICITY IN BET PROTEINS THROUGH SIMULA TIONS AND NMR. Alberto Perez 1621-Pos Board B26 MOLECULAR AND STRUCTURAL INSIGHT INTO THE DIFFERENCES AMONG COMMON AND RARE ALZHEIMER’S DISEASE-ASSOCIATED APOE VARI ANTS. Rory A. Greer , Ryan A. Tuckey, Hunter B. Dean, Erik D. Roberson, Yuhua Song

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