Biophysical Society 67th Annual Meeting Program Guide

1636-Pos Board B41 PROBING THE ROLE OF RNA ON PRION PROTEIN AND PRION FIBRIL REC OGNITION. Brian W. Paul , Hannah O. Brockman, Patricia Soto 1637-Pos Board B42 UNRAVELING THE ENTHALPY OF MACROMOLECULAR CROWDING. Claire J. Stewart , Gil Olgenblum, Daniel Harries, Gary J. Pielak 1638-Pos Board B43 ALTERED CONFORMATIONAL LANDSCAPE UPON SENSING GUANINE NUCLEOTIDES IN A DISEASE MUTANT OF ELONGATION FACTOR-LIKE 1 (EFL1) GTPASE. Jesús P.J. Pérez Juarez 1639-Pos Board B44 NASCENT-CHAIN INTERACTION NETWORKS AND THEIR EFFECT ON THE BACTERIAL RIBOSOME. Meranda Masse , Angela Varela, Valeria Guzman Luna, Rachel Hutchinson, Aniruddha Srivastava, Wanting Wei, AndrewM. Fuchs, Silvia Cavagnero 1640-Pos Board B45 EXAMINING THE IMPORTANCE OF TERMINI LOCATION IN SUCCESSFUL PROTEIN FOLDING WITH HALOTAG CIRCULAR PERMUTANTS IN VITRO, IN E. COLI, AND IN MAMMALIAN CELLS. Natalie R. Dall , Carolina A.T.F. Mendonca, Susan Marqusee 1641-Pos Board B46 INVESTIGATING THE STRUCTURAL MECHANISM OF GAMMA-D CRYSTAL LIN AGGREGATION. Sara Volz , Alex J. Guseman, Susan Marqusee, Angela M. Gronenborn 1642-Pos Board B47 INVESTIGATING THE MECHANISM OF SUPPRESSION OF HUMAN ΓD CRYSTALLIN AGGREGATION BY MYO -INOSITOL. Constance Kraay , Eugene Serebryany, Srivastav Ranganathan, Eugene Shakhnovich 1643-Pos Board B48 A NATIVE CHEMICAL CHAPERONE IN THE HUMAN EYE LENS SUPPRESSES REDOX-DEPENDENT LENS CRYSTALLIN MISFOLDING. Eugene Serebryany , Sourav Chowdhury, Christopher Woods, David C. Thorn, Nicki E. Watson, Arthur McClelland, Rachel Klevit, Eugene Shakhnovich 1644-Pos Board B49 PHARMACOCHAPERONES AS A NOVEL APPROACH TO RESCUE MISFOLD ING ROD OPSIN MUTANTS ASSOCIATED WITH RETINITIS PIGMENTO SA. Beata Jastrzebska 1645-Pos Board B50 BIOCHEMICAL AND MOLECULAR CHARACTERIZATION OF THE MOST COMMON SLC13A5-EPILEPSY CAUSING MISSENSE-MUTATIONS. Valeria Jaramillo-Martinez , Vadivel Ganapathy, Ina Urbatsch 1646-Pos Board B51 PROBING UNFOLDING BARRIERS IN HIGH THROUGHPUT. Eva Gerber , Miriam R. Hood, Susan Marqusee 1647-Pos Board B52 INVESTIGATING DIFFERENCES BETWEEN THERMODYNAMICALLY AND KINETICALLY STABLE SUBTILISINS TO IDENTIFY SEQUENCE SIGNATURES OF KINETIC STABILITY. Miriam R. Hood , Susan Marqusee Protein-Small Molecule Interactions II (Boards B53 - B70) 1648-Pos Board B53 DESIGNING BCL-2 PROTEIN BINDING APTAMERS USING SCREENED COU LOMB INTERACTION METHOD & REGULATE APOPTOSIS. Ekram Hawsawi , Hanouf Almansour, Md. Ashrafuzzaman

1622-Pos Travel Award Winner SEQUENCE ADAPTATION IN VARIOUS ENVIRONMENTS ACROSS ORGAN ISMS; SIMILAR YET DIFFERENT SUPEROXIDE DISMUTASE. Ivy D. Vo , Ellinor Haglund 1623-Pos Board B28 INVESTIGATION OF REFRACTIVE INDEX INCREMENT WITH CRYSTALLIN PROTEIN AGGREGATION. Amanda Abiad , Megan A. Rocha, Rachel W. Martin 1624-Pos Board B29 INVESTIGATION OF THE POTENTIAL OFF-TARGET EFFECTS ON MUNC 18 (P67) INVOLVED IN SYNAPTIC VESICAL TRANSPORT DUE TO THE INTERAC TION WITH PEPTIDE P5. Tejaswi Tammareddy , Antonio Cardone, Harish C. Pant, Walid Keyrouz, Ram Sriram, Jeffery B. Klauda 1625-Pos Board B30 APPLICATIONS OF HYDROGEN DEUTERIUM EXCHANGE ENSEMBLE RE WEIGHTING TO MODEL NATIVE PROTEIN ENSEMBLES, MACROMOLECU LAR INTERACTIONS AND PROTEIN DRUG INTERACTIONS. Kyle C. Kihn, Ally K. Smith, Daniel J. Deredge 1626-Pos Board B31 STRUCTURAL EFFECTS OF ALS-ASSOCIATED MUTATIONS ON PRO FILIN. Mortaza Derakhshani-Molayousefi , Vivek Govind Kumar, Mah moud Moradi 1627-Pos Board B32 THE FATE OF THE CDTA SUBUNIT FROM THE HAEMOPHILUS DUCREYI CYTOLETHAL DISTENDING TOXIN​. Robb Huhn , Nalysha Torres, Mike Talyor, Travel Award Winner STRUCTURAL BASIS OF SIGNAL TRANSDUCTION WITHIN PAS REGULATED SER/THR KINASE. Roksana Azad 1629-Pos Board B34 STRUCTURAL BASIS FOR THE RECRUITMENT OF PARP4 AND NAD + TO THE VAULT COMPLEX. Jane E. Lodwick , Minglei Zhao 1630-Pos Board B35 EFFECT OF FATTY ACIDS AND PH ON THE BINDING OF BSA TO SILICA AND POLYSTYRENE. Adam Okerlund , Alexis Rose, Viana Nguyen, Christopher Warner Protein Stability, Folding, and Chaperones I (Boards B36 - B52) 1631-Pos Board B36 ON THE ROLE OF COOPERATIVITY IN FUNNELED ENERGY LAND SCAPES. David Wang , Layne Frechette, Robert B. Best 1632-Pos Board B37 STABILITY OF TANDEM IG DOMAIN UNFOLDING WITHIN PROXIMAL IG SEGMENT OF TITIN. Smita Chatterjee , Matthew Gage 1633-Pos Board B38 LEARNING REACTION COORDINATES FOR ENHANCED SAMPLING DI RECTLY USING ATOMIC POSITIONS. Subarna Sasmal , Martin McCullagh, Glen M. Hocky 1634-Pos Board B39 FOLDING AND THREADING OF LEPTIN AS A MODEL FOR PIERCED LASSO TOPOLOGIES. Jennifer M. Simien , Ellinor Haglund 1635-Pos Board B40 TOPOLOGICAL TWISTS IN NATURE: PROTEINS WITH A PIERCED LASSO TOPOLOGY. Ellinor Haglund Board B27 Ken Teter 1628-Pos Board B33

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