Biophysical Society 67th Annual Meeting Program Guide

1742-Pos Board B147 D-RNA SELECTS L-AMINO ACIDS IN A NEWLY CHARACTERIZED AMINOAC YL-RNA LOOP LIGATION. Shannon N. Kim 1743-Pos Board B148 MECHANISTIC INSIGHTS INTO THE 2-STEP DIMERIZATION PROCESS FO THE HEPATITIS C VIRUS RNA GENOME. Parker D. Sperstad , Erik D. Holm strom 1744-Pos Board B149 DELTA VARIANT VERSUS ANCESTRAL SARS-COV-2 S2M DYNAMICS AND RELATIVE ENTROPY. Joseph A. Makowski , Adam H. Kensinger, Kendy A. Pellegrene, Caylee Cunningham, Caleb J. Frye, Patrick E. Lackey, Mihaela Rita Mihailescu, Jeffrey D. Evanseck 1745-Pos Board B150 REDUCTIONIST INSIGHTS INTO HOW CHAPERONE CHARGE INFLUENCES RNA FOLDING. Gabrielle Perkins , Erik D. Holmstrom 1746-Pos Board B151 Travel Award Winner SOLUTION STRUCTURE OF POLY(UG) RNA REVEALS A NEW FOLD THAT DRIVES GENE SILENCING. Cristian A. Escobar , Riley J. Petersen, Marco Tonelli, Lixin Fan, Yun-Xing Wang, Jenny Yan, Scott G. Kennedy, Samuel E. Butcher 1747-Pos Board B152 MOLECULAR MODELING OF PARP1 INHIBITION THROUGH MIRNA GENE SILENCING FOR THE TREATEMENT OF RETINITIS PIGMENTOSA. Lalehan Oktay , Aylin Moayedi, Zohreh Hosseinzadeh, Serdar Durdagi 1748-Pos Board B153 VIRAL-HOST RNA-RNA INTERACTIONS IN SARS-COV-2: STUDY OF MIR 34A-5P BINDING INTERACTIONS WITHIN THE GENOME 3’-UNTRANS LATED REGION. Caleb J. Frye , Caylee Cunningham, Adam H. Kensinger, Joseph A. Makowski, Jeffrey D. Evanseck, Mihaela-Rita Mihailescu 1749-Pos Board B154 SINGLE-MOLECULE FRET REVEALS DYNAMICS OF DENGUE VIRAL REPLICATION PROMOTER STEM-LOOP A INTERACTING WITH NS5-POLY MERASE. Alexander R. Smith , Joel A. Crossley 1750-Pos Board B155 SYSTEMATIC RECONSTRUCTION OF THE FULL GENOME STRUCTURE OF AN RNA VIRUS USING RESTAINED MULTISCALE SIMULATIONS ON A DIS TRIBUTED COMPUTATION PLATFORM. Simón Poblete , Fernando Mora, Pablo Huijse, Cristian Huijse, Sebastian Etchegaray 1751-Pos Board B156 STRUCTURAL AND THERMODYNAMIC CONSEQUENCES OF THE G31U AND U5C MUTATIONS IN THE SARS-COV-2 S2M. Adam H. Kensinger , Joseph A. Makowski, Kendy A. Pellegrene, Caylee L. Cunningham, Caleb J. Frye, Patrick E. Lackey, Mihaela-Rita Mihailescu, Jeffrey D. Evanseck 1752-Pos Board B157 UNCOVERING THE BIOPHYSICAL MECHANISMS OF RIBOREGULATORY IN TERACTIONS INVOLVING THE HEPATITIS C VIRUS 3´X RNA USING SINGLE MOLECULE FRET. Parker Sperstad, Erik D. Holmstrom 1753-Pos Board B158 UNSUPERVISED LEARNING FROM TOPOLOGICAL DATA ANALYSIS TO IDEN TIFY CELLULAR STATES FROM SINGLE-CELL RNA-SEQ ANALYSIS. Aydolun Petenkaya , Chuansheng Hu, Constantinos Chronis, Zhifeng Shao, Jie Liang 1754-Pos Board B159 RIBOSOME HYPER-SWIVEL HEAD DOMAIN MOTIONS ARE REQUIRED FOR TRANSLOCATION AND RESETTING. Dylan J. Girodat, Wataru Nishima, Mikael Holm, Emily J. Rundlet, Jigneshkumar D. Prajapati, Jose L. Alejo Amaya, Kara Fischer, Scott C. Blanchard, Karissa Y. Sanbonmatsu

1730-Pos Board B135 SINGLE-MOLECULE FRET REVEALS DINSTINCT MUTS CONFORMATIONAL DYNAMICS ON DIFFERENT DNA MISMATCHES. Rachel Evans , Dorothy A. Erie, Keith R. Weninger 1731-Pos Board B136 STIMULATION OF TDG BY UV-DDB. Brittani L. Schnable , Matthew A. Schaich, Alexander C. Drohat, Bennett Van Houten 1732-Pos Board B137 RAD51 FILAMENT FORMATION, DYNAMICS, AND REGULATION. Kailey Cash , Maria Spies 1733-Pos Board B138 NOVEL INSIGHTS ABOUT RIBOSOMAL DNA DOUBLE STRAND BREAK RE PAIR REVEALED BY SUPERRESOLUTION IMAGING TECHNIQUES AND VERY FAST CRISPR. Ye Ma 1734-Pos Board B139 FOCUS IN NUMBERS: CHARACTERIZING PROTEIN OLIGOMERIZATION DYNAMICS AT DNA DOUBLE STRAND BREAKS. Graziana Modica , Joannie Roy, Hugo Wurtele, Santiago Costantino 1735-Pos Board B140 STUDIES OF THE LOCAL ASSEMBLY DYNAMICS OF THE T4 BACTERIO PHAGE HELICASE LOADING PROTEIN (GP59) AND SINGLE-STRANDED (SS) DNA BINDING PROTEIN (GP32) AT AND NEAR (ICY3) 2 -LABELED SS-DSDNA JUNCTIONS BY ENSEMBLE AND SINGLE-MOLECULE POLARIZATION SWEEP MICROSCOPY. Lulu Enkhbaatar , Dylan Heussman, Jack W. Maurer, Patrick J. Herbert, Peter H. von Hippel, Andrew H. Marcus 1736-Pos Board B141 STUDY ON BIOPHYSICAL PROPERTIES OF PHI29 DNA POLYMERASE USING A NOVEL SINGLE-MOLECULE IMAGING TECHNIQUE DNA CURTAIN. Subin Kim , Ja Yil Lee 1737-Pos Board B142 INVESTIGATING LOCAL DNA CONFORMATIONAL TRAPPING DYNAMICS DURING DNA POLYMERASE HOLOENZYME ASSEMBLY AND EXONUCLE ASE PROOF-READING ACTIVITY. Patrick J. Herbert , Jack W. Maurer, Dylan Heussman, Steven E. Weitzel, Peter H. von Hippel, Andrew H. Marcus RNA Structure and Dynamics (Boards B143 - B162) 1738-Pos Board B143 DEVELOPMENT OF AN APTAMER-BASED SCREENING FOR IDENTIFICA TION AND CHARACTERIZATION OF NOVEL RNA THERAPEUTICS USING SWITCHSENSE® TECHNOLOGY. Mareike Weller , Michael Sattler, Ulrich Rant 1739-Pos Board B144 MECHANISM OF LIGAND BINDING SIGNAL TRANSDUCTION IN A TRAN SCRIPTIONAL RIBOSWITCH. Sunil Kumar, Govardhan Reddy Patluri 1740-Pos Board B145 Travel Award Winner COARSE-GRAINED RNA SIMULATIONS WITH CONCERTED C2’/C3’-ENDO SUGAR PUCKER TRANSITIONS. Yiheng Wu , Riccardo Alessandri, Aria Coraor, Xiangda Peng, Tobin R. Sosnick, Juan J. de Pablo 1741-Pos Board B146 SINGLE-MOLECULE SPATIAL TRANSCRIPTOMICS DEMONSTRATES SPATIAL HETEROGENEITY OF PRE-MIRNA AND CLASSIFIES Β-CELLS IN TYPE 1 DIABETES. Hok Wai Chang , Clayton Seitz, Farooq Syed, Carmella Evans Molina, Jing Liu

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