Biophysical Society 67th Annual Meeting Program Guide

Platform Intrinsically Disordered Proteins I 8:15 am - 10:15 am, Room 6C

Sunday, February 19

F R I D A Y

S U N D A Y

Postdoctoral Breakfast 7:30 am - 8:30 am, Room 2 Registration/Exhibitor Registration 7:30 am - 5:00 pm, Lobby BC Poster Viewing 8:00 am - 10:00 pm, Exhibit Hall BC Symposium The Molecular Sarcomere 8:15 am - 10:15 am, Room 6A

Co-Chairs Jagannath Mondal, Tata Institute of Fundamental Research, India Sara Sohail, NIH, USA 8:15 am AN ENTROPIC EXPANSION MECHANISMMODULATES SMALL-MOLECULE RECOGNITION BY ALPHA-SYNUCLEIN. Jagannath Mondal , Sneha Menon 38-plat 8:30 am MULTIMODAL INTERACTIONS BETWEEN A DISORDERED PROTEIN AND ITS FOLDED TARGET AT SINGLE-MOLECULE LEVEL. Spencer Smyth , Claudiu C. Gradinaru, Julie D. Forman-Kay 39-plat 8:45 am INVESTIGATING THE MECHANISM OF DNA BINDING ENHANCEMENT BY THE RELA TRANSCRIPTION ACTIVATION DOMAIN. Hannah E. R. Baughman , David Han, Tristan R. Gunther, Elizabeth A. Komives 40-plat 9:00 am STRUCTURAL PREFERENCES MODULATE THE ENTROPIC FORCE EXERTED BY DISORDERED PROTEINS. Feng Yu , Shahar Sukenik 9:15 am Flash Talks 41-plat 9:30 am THE “STRUCTURAL” JOURNEY OF A RIBONUCLEOPROTEIN COMPLEX: FROMMOLECULES TO DROPLETS. Rishav Mitra , James C. Bardwell 42-plat 9:45 am SINGLE MOLECULE FRET IMAGING AND DEEP LEARNING REVEAL CON CENTRATION DEPENDENCE OF AGGREGATION PATHWAYS DURING AΒ AGGREGATION. Sara Sohail , Janghyun Yoo, Hoi Sung Chung 43-plat 10:00 am SOLUBILITY OF THE AM YLOIDOGENIC CORE OF TAU IN CSF. Emil Axell , Emma Sparr, Sara Linse Platform Protein-Nucleic Acid Interactions I 8:15 am - 10:15 am, Room 6D Co-Chairs Kathryn Lebold, NIH, USA Matthew Newton, Francis Crick Institute, United Kingdom Travel Award Winner SINGLE-MOLECULE IMAGING OF THE MCDA ATPASE REVEALS MECHANIS TIC DETAILS OF CARBOXYSOME TRAFFICKING. Christopher A. Azaldegui , Lisa T. Pulianmackal, Cade T. Harkner, Luis A. Ortiz-Rodríguez, Jose Miguel I. Limcaoco, Anthony G. Vecchiarelli, Julie S. Biteen 45-plat 8:30 am DIRECT OBSERVATION OF SHELTERIN DYNAMICS AND T-LOOP FORMA TION AT TELOMERES. Matthew D. Newton , Jacob S. Lewis, Roopesh Anand, Elizabeth P. Holmes, Alice L.B. Pyne, Simon J. Boulton 46-plat 8:45 am STEP-BY-STEP BINDING AND UNWINDING OF RNA BY A DED1P TRIMER REVEALED BY COMBINED HIGH-RESOLUTION TWEEZERS AND FLUORES CENCE MEASUREMENTS. Kasun B. Senanayake , Rajeev Yadav, Kyle D. Cotter, Eric M. Patrick, Andrea A. Putnam, Eckhard Jankowski, Matthew J. Comstock 37-plat 44-plat 8:15 am

Chair Samantha Harris, University of Arizona, USA 30-symp 8:15 am

SARCOMERE MODEL: FLUCTUATIONS DRIVE ENERGY CONSUMPTION IN STRIATED MUSCLE UNDER CONSTANT LOAD. Andrew Schmidt, Alexander Y. Grosberg, Anna Grosberg 31-symp 8:45 am THE ROLE OF ALPHA ACTININ PARALOGS IN CARDIAC HYPERTROPHY AND CONTRACTILE FORCE PRODUCTION. Dylan T. Burnette , James B. Hayes 32-symp 9:15 am CRYO-ET REVEALS SARCOMERE STRUCTURES AT MOLECULAR RESOLU TION. Stefan Raunser 33-symp 9:45 am MYOSIN BINDING PROTEIN-C: EVERYTHING, EVERYWHERE, ALL AT ONCE. Samantha P. Harris Symposium 50 Years After the Fluid Mosaic Membrane 8:15 am - 10:15 am, Room 6B Chair Sarah Keller, University of Washington, USA 34-symp 8:15 am MITOCHONDRIAL PERMEABILIZATION IN APOPTOSIS: ADVANCED MI CROSCOPY APPROACHES. Ana J. Garcia-Saez No Abstract 8:45 am HOW THE LIPID BILAYER AFFECTS PROTEIN STABILITY. Karen G. Fleming 35-symp 9:15 am NONEQUILIBRIUM CONTROL OF CELL MEMBRANE ORGANISATION - AC TIVE EMULSIONS. Madan Rao - IUPAB Sponsored Speaker 36-symp 9:45 am REVERSIBLE, LARGE-SCALE, LIQUID-LIQUID PHASE SEPARATION IN LIVING YEAST MEMBRANES. Sarah Keller , Chantelle Leveille, John Reinhard, Caitlin E. Cornell, Glennis E. Rayermann, Scott P. Rayermann, Christian Klose, Robert Ernst, Alexey J. Merz

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