Biophysical Society 67th Annual Meeting Program Guide

Platform Voltage-Gated K Channels 8:15 am - 10:15 am, Room 6F

47-plat 9:00 am ASYMMETRIC VIRAL GENOMIC RNA EGRESS FROM A SPRING-LOADED VIRUS THROUGH RUBONUCLEOPROTEIN REARRANGEMENTS. Sean Braet , Varun Venkatakrishnan, Ranita Ramesh, Palur Raghuvamsi, Ganesh S. Anand 48-plat 9:15 am STRUCTURAL STUDIES OF RB69 POLYMERASE-DNA COMPLEX. Weijia Kang , Xiaoli Zeng, Medine Ayhan, Jane E. Lodwick, Minglei Zhao, Zhong Ren, Xiaojing Yang 49-plat 9:30 am THE BIOPHYSICAL MODULATION AND RNA INTERFERENCE ARE TWO IN DEPENDENT ACTIONS OF MICRORNA. Dandan Yang , Xiaoping Wan, Feng Tang, Saanvi Ganesh, Tithi Shah, Isabelle Deschenes, Jidong Fu 50-plat 9:45 am CONTROL OF BACTERIAL IMMUNE SIGNALING BY A WYL DOMAIN TRAN SCRIPTION FACTOR. Chelsea Blankenchip , Justin Nguyen, Rebecca Lau, Qiaozhen Ye, Yajie Gu, Kevin D. Corbett 51-plat 10:00 am TOP-DOWN COARSE-GRAINED MODEL FOR SINGLE STRANDED NUCLEIC ACIDS. Kathryn Lebold , Robert B. Best Platform Protein Structure and Conformation I 8:15 am - 10:15 am, Room 6E Co-Chairs Krisztina Varga, University of New Hampshire, Durham, USA Jie Yang, Scripps Research, USA 52-plat 8:15 am BIOPHYSICAL CHARACTERIZATION AND APPLICATIONS OF AN INSECT ANTIFREEZE PROTEIN. Krisztina Varga , Korth W. Elliott, Christopher Nor dyke, Jonathan A. Sreter, Katarina Jovic, Logan M. Brown 53-plat 8:30 am LIGAND INDUCED DIMERIZATION AND TOPOLOGY OF A KNOTTED SPOUT METHYLTRANSFERASE. Tiange Tao 54-plat 8:45 am DOMESTICATED CONJUGATION MACHINERY PROMOTES DNA EXCHANGE IN HYPERTHERMOPHILIC ARCHAEA. Leticia Beltran , Virginija Cvirkaite Krupovic, Jessalyn Roberts, Fengbin Wang, Mark A. Kreutzberger, Tiago Costa, Ilya Levental, Vincent Conticello, Edward H. Egelman, Mart Krupo vic 55-plat 9:00 am DELE1 OLIGOMERS REVEALED BY CRYO-EM STRUCTURE PROMOTE THE INTEGRATED STRESS RESPONSE ACTIVATION. Jie Yang 9:15 am Flash Talks 56-plat 9:30 am Travel Award Winner A MOLECULAR MOVIE OF NUCLEOTIDE ADDITION BY HIV-1 REVERSE TRANSCRIPTASE. Sandra Vergara , Zhou Xiahong, Nicolas Sluis-Cremer, Guillermo Calero 57-plat 9:45 am REGULATION OF DIIRON ACTIVE SITE OF SMMO THROUGH REGULATORY AND REDUCTASE COMPONENTS FROM METHYLOSINUS SPORIUM 5. Yunha Hwang , Seung Jae Lee 58-plat 10:00 am MUTATIONS IN A HUMAN KINASE CAUSE DRUG RESISTANCE BY SHIFTING CONFORMATIONAL STATE DISTRIBUTIONS. Gabriel M. da Silva , Brenda M. Rubenstein

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Co-Chairs Magalí Colomer-Molera, University of Barcelona, Spain Izhar Karbat, Weizmann Institute of Science, Israel

59-plat Travel Award Winner DEFINING THE INTERACTIONS BETWEEN HCN4 AND THE REGULATORY PROTEINS IRAG AND LRMP. Rohit K. Singh , Avery A. Langley, Colin H. Peters, John Bankston, Cathy Proenza 60 -plat 8:30 am Travel Award Winner PAIRWISE BIOSYNTHESIS ESTABLISHES ION CHANNEL BALANCE AND MITIGATES ARRHYTHMIA. Margaret B. Jameson , Erick B. Rios Perez, Fang Liu, Avtar S. Roopra, Catherine A. Eichel, Gail A. Robertson 61-plat 8:45 am DEVELOPMENT OF IKS ACTIVATING COMPOUNDS FOR TREATMENT OF LONG QT SYNDROME. Jessica Jowais , Laura Maria Castro Gonzalez, Sara I. Liin, Peter D. Tieleman, Peter H. Larsson 62-plat 9:00 am ROLE OF LIPIDS IN HYDROPHOBIC GATING AND BLOCKER AFFINITY IN BK CHANNELS. Lucia Coronel , Alexandre G. Vouga, Brad S. Rothberg, Vincenzo Carnevale 63-plat 9:15 am TRIMMING THE DISORDERED C-TERMINAL EXTENSION OF THE PROTE ASE INHIBITOR HG1 PRODUCES A POTENT K V 1.3 BLOCKER. Chandamita Saikia, Hagit Altman-Gueta, Shachar Fine, Orly Dym, Felix Frolow, Eitan Reuveny, Izhar Karbat 64-plat 9:30 am INACTIVATION MECHANISM OF AN IMMUNOGLOBULIN MODULATOR OF THE T-CELL POTASSIUM CHANNEL KV1.3. Purushotham Selvakumar , Ana I. Fernández-Mariño, Bing Wang, William J. Rice, Joel R. Meyerson, Kenton J. Swartz 65-plat 9:45 am K V 1.3-DEPENDENT IMMUNE SYSTEM ACTIVATION IS REGULATED BY KCNE4. Magalí Colomer-Molera , Daniel Sastre, Laura Sole Codina, Albert Vallejo-Gracia, Maria Navarro Perez, Jesusa Capera-Aragones, Irene Est adella, Silvia Cassinelli, Gyorgy Panyi, Peter B. Hajdu, Michael M. Tamkun, Antonio Felipe 66 -plat 10:00 am A POINT MUTATION TURNS AN INACTIVATED POTASSIUM CHANNEL INTO A HYPERPOLARIZATION ACTIVATED CATION CHANNEL. Bernardo I. Pinto , Carlos Alberto Z. Bassetto Jr, Francisco Bezanilla Platform Membrane Receptors and Signal Transduction 8:15 am - 10:15 am, Room 5AB Co-Chairs 8:15 am 67-plat 8:15 am IT TAKES TWO TO TANGO: CROSSTALK BETWEEN INNATE IMMUNE RECEPTORS. Yan Yu 68 -plat 8:30 am Travel Award Winner UNDERSTANDING HOW ANTIGEN MOBILITY AND ADHESION MOLECULES INFLUENCE B CELL ACTIVATION. Hannah C.W. McArthur, Anna T. Bajur, Maro Iliopoulou , Katelyn M. Spillane Anne Robinson, Carnegie Mellon University, USA Yan Yu, Indiana University, Bloomington, USA

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