Biophysical Society 67th Annual Meeting Program Guide

480-pos Board B301 CARDIOPROTECTIVE ROLE OF INNER MEMBRANE CHLORIDE CHANNEL, CLIC5 FROM ISCHEMIA-REPERFUSION INJURY. Devasena Ponnalagu , Diego Antelo, Ahmed T. Hussain, Erhe Gao, Walter Koch, Harpreet Singh 481-pos Board B302 CARDIOPROTECTION WITH A BKCA CHANNEL ACTIVATOR IMPROVES POST-ISCHEMIC CARDIAC RECOVERY IN PIGS AND NORMALIZES ALTERED MITOCHONDRIAL PROTEIN EXPRESSION ASSESSED BY TMT-MS. Wenzhuo Ma , Neel Sodha, Martin Kolodziejczak, Zhiqi Zhang, Afshin Ehsan, Scarlett Huck, Clarissa Cavarsan, Frank Sellke, Jun Feng, Dmitry A. Terentyev, Richard T. Clements 482-pos Board B303 KNOCK-OUT OF MITOCHONDRIAL NUCLEOSIDE DIPHOSPHATE KINASE NME4 REVEALS SURPRISING TISSUE-DISTRIBUTION AND REMODELED CELL SIGNALING, SUGGESTIVE OF MULTIPLE FUNCTIONS. Malgorzata Tokarska-Schlattner , Baraa Rstom, Cindy Tellier, Stephane Attia, Laurence Kay, Uwe Schlattner 483-pos Board B304 OPTICAL MODULATION OF MITOCHONDRIAL MORPHOLOGY AND FUNC TIONS. Kangqiang Qiu, Weiwei Zou, Hongbao Fang, Minggang Hao, Kritika Mehta, Zhiqi Tian, Jun-Lin Guan, Taosheng Huang, Jiajie Diao, Kai Zhang 484-pos Board B305 DISSECTING THE LIPIDIC DETERMINANTS OF INNER MITOCHONDRIAL MEMBRANE STRUCTURE. Kailash Venkatraman , Christopher T. Lee, Guadalupe Garcia, Arijit Mahapatra, Keunyoung Kim, Guy Perkins, Sebas tien Phan, Hilda A. Pasolli, Jennifer Lippincott-Schwartz, Mark Ellisman, Padmini Rangamani, Itay Budin 485-pos Board B306 MITOCHONDRIAL TEMPORAL NETWORK TRACKING FOR 4D LIVE-CELL FLUORESCENCE MICROSCOPY DATA. Zichen Wang , Parth Natekar, Chal lana Tea, Sharon Tamir, Hiroyuki Hakozaki, Johannes Schöneberg 486-pos Board B307 MITOCHONDRIAL RUPTURE AFTER PHOTODAMAGE INITIATES PARKIN INDEPENDENT MITOPHAGY IN MOUSE HEPATOCYTES. Li li , Jiangting Hu, Zhi Zhong, Eeva-Liisa Eskelinen, John J. Lemasters Voltage-Gated Na Channels (Boards B308 - B333) 487-pos Board B308 BIOPHYSICAL PROPERTIES OF NA V 1.5 CHANNEL IN VENTRICULAR-LIKE AND ATRIAL-LIKE CHAMBER CARDIOMYOCYTES DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS. Charles-Albert Chapotte-Baldacci , Marion Pierre, Mohammed Djemaï, Mohamed Chahine 488-pos Board B309 CALMODULIN BINDS FGF12A TO REGULATE NAV1.5 CHANNEL INACTI VATION. Lucy S. Woodbury , Paweorn Angsutararux, Martina Marras, Carlota Abella, Jonathan R. Silva 489-pos Board B310 A DE NOVO ARRHYTHMOGENIC NAV1.5 VARIANT, E171Q, CAUSES MULTIPLE BIOPHYSICAL DEFECTS. Mohamed Fouda, AndrewM. Glazer, Tao Yang, Dana A. Page , Yuko Wada, Shubhayan Sanatani, Dan M. Roden, Peter C. Ruben 490-pos Board B311 ARUMENAMIDES : A NOVEL CLASS OF POTENTIAL ANTI-ARRHYTHMIC COMPOUNDS. Mena Abdelsayed , Dana A. Page, Peter C. Ruben 491-pos Board B312 INFLAMMATION PROVOKES GATING CHANGES IN THE NEURONAL VOLTAGE-GATED SODIUM CHANNEL, NAV1.6. Mohamed Fouda, Peter C. Ruben

492-pos Travel Award Winner CHARACTERIZATION OF ATRIAL FIBRILLATION LINKED MUTATIONS USING THE NA V 1.5 KNOCK-OUT OF ATRIAL CARDIOMYOCYTES DERIVED FROM IPSCS. Marion Pierre , Charles-Albert Chapotte-Baldacci, Mohammed Djemai, Mohamed Chahine 493-pos Board B314 ENHANCEMENT OF EFL-INACTIVATION GATE INTERACTION BY TRUN CATION OF NAV1.5 CARBOXY-TERMINAL DOMAIN. Ryan W. Mahling , Nourdine Chakouri, Manu Ben-Johny 494-pos Board B315 EFFECTS OF MEXILETINE ON A RACE-SPECIFIC MUTATION IN NAV1.5 AS SOCIATED WITH LONG QT SYNDROME. Xin Wu, Yawei Li, Liang Hong 495-pos Board B316 ELUCIDATING THE DIFFERENTIAL MUTATIONAL EFFECTS OF GATING CHARGES IN VOLTAGE-GATED SODIUM CHANNELS. Eslam Elhanafy , Amin Akbari Ahangar, Jing Li 496-pos Board B317 EFFECTS OF ELECTRIC-FIELD RESHAPING ON VOLTAGE SENSING IN VOLTAGE-GATED SODIUM CHANNELS. Andrei Y. Kostritskii , Jan-Philipp Machtens 497-pos Board B318 HIGH-LEVEL EXPRESSION OF VOLTAGE-GATED SODIUM CHANNELS IN THYMIDINE-ARRESTED HUMAN EMBRYONIC KIDNEY CELLS. Ahmed Eltokhi , Tamer M. Gamal El-Din, William A. Catterall 498-pos Board B319 A NOVEL HIGH THROUGHPUT COMBINED VOLTAGE-CLAMP/CURRENT CLAMP ANALYSIS OF SINGLE PRIMARY NEURONS. Mohammad-Reza Ghovanloo , Sidharth Tyagi, Peng Zhao, Emre Kiziltug, Mark Estacion, Sulayman Dib-Hajj, Stephen G. Waxman 499-pos Board B320 FINE-STRUCTURE CONSTANT AND HYSTERESIS REGIMES IN THE GIANT SQUID PROPAGATING ACTION POTENTIAL. Nikola K. Jurisic , Fred Cooper 500-pos Board B321 NO EVIDENCE OF FUNCTIONAL INTERACTIONS BETWEEN CARDIAC SODIUM CHANNELS. Zoja Selimi , Jean-Sébastien Rougier, Hugues Abriel, Jan P. Kucera 501-pos Board B322 USING ROSETTA AND ALPHAFOLD TO ASSESS JINGZHAOTOXIN-III BIND ING TO HNA V 1.5 AND HK V 2.1. Brandon J. Harris , Diego Lopez Mateos, Geir Hareland, Vladimir Yarov-Yarovoy 502-pos Board B323 STRUCTURAL BASIS FOR SEVERE PAIN CAUSED BY MUTATIONS IN VOLTAGE GATED SODIUM CHANNELS NA V 1.7. Tamer M. Gamal El-Din , Goragot Wisedchaisri, William A. Catterall 503-pos Board B324 COMPOSITION OF TTX-S NA V CURRENT IN RAT MUSCLE AFFERENT NEU RONS. Khrystyna Sukhanova , Jeong Sook Kim-Han, Keith S. Elmslie 504-pos Board B325 COMPUTATIONAL DESIGN OF PEPTIDES STABILIZING NAV1.7 CHANNEL IN AN INACTIVATED STATE. Diego Lopez Mateos , Adriana Hernandez Gonza lez, Vladimir Yarov-Yarovoy 505-pos Board B326 A DIGITALLY-MODULATED CONDUCTANCE CLAMP ELIMINATES INSTABIL ITY OBSERVED WITH LARGER CURRENT SIGNALS IN CONVENTIONAL DYNAMIC CLAMP. Anthony Costantino, Mark W. Nowak, Leigh Korbel, Alex Kane, Glenna Bett, Randall L. Rasmusson Board B313

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