Biophysical Society 67th Annual Meeting Program Guide

454-pos Board B275 ELASTIC PROPERTIES OF THE INNER-EAR TIP LINK EXPLORED USING ALL ATOMMOLECULAR DYNAMICS SIMULATIONS. Carter T. Wheat , Jasanvir Sandhu, Elakkiya Tamilselvan, Pedro De-la-Torre, Joseph C. Sudar, Travis Harrison-Rawn, Marissa Boyer, Qurat Ashraf, Daisy Alvarado, Marcos M. Sotomayor 455-pos Board B276 MEMBRANE CURVATURE REGULATES THE SPATIAL DISTRIBUTION OF BULKY GLYCOPROTEINS. Chih-Hao Lu 456-pos Board B277 TMC REGULATES MEMBRANE VISCOSITY IN MAMMALIAN COCHLEAR HAIR CELLS. Shefin Sam George , Amel El Bahloul-Jaziri, Anthony J. Ricci 457-pos Board B278 Travel Award Winner CHOLESTEROL AS A TOOL TO PROBE THE ROLE OF MEMBRANE IN COCHLEAR HAIR CELL MECHANOTRANSDUCTION. Shefin Sam George , Thomas Effertz, Anthony J. Ricci 458-pos Board B279 PREDICTING CONDUCTION PROPERTIES OF TMC PROTEINS INVOLVED IN SENSORY PERCEPTION IN SILICO . Shounak Mukherjee , Harsha Manday am Bharathi, Wei-Hsiang Weng, Travis Harrison-Rawn, Hariharan Kannan, Quratulayn Ashraf, Marcos M. Sotomayor 459-pos Board B280 MECHANICAL VS. AGONIST INDUCED ACTIVATION IN THE ANGIOTENSIN II TYPE 1 RECEPTOR. Bharat Poudel, Rajitha R. Tatikonda, Juan M. Vanegas 460-pos Board B281 SINGLE PICONEWTON FORCES REGULATE DISSOCIATION OF THE LATROPHILIN-3 GAIN DOMAIN. Brian L. Zhong , Christina E. Lee, Vipul T. Vachharajani, Thomas C. Sudhof, Alexander R. Dunn Mitochondria in Cell Life and Death (Boards B282 - B307) 461-pos Board B282 THE SINGLE RESIDUE K12 GOVERNS HIGHLY SENSITIVE VOLTAGE GATING OF THE VOLTAGE-DEPENDENT ANION CHANNEL. Van Ngo, Maria Queralt Martin, Farha Khan, Lucie A. Bergdoll, Jeff Abramson, Sergey M. Bezrukov, Tatiana K. Rostovtseva, Sergei Y. Noskov, David P. Hoogerheide 10 Board B283 SMALL MOLECULES TARGETING THE NADH-BINDING POCKET OF VDAC ENHANCE T CELL CYTOTOXICITY AND SELECTIVELY INHIBIT CANCER CELL PROLIFERATION. Milagros Junco, Paramita Chakraborty, Clara Ventura, Ka reem A. Heslop, Monika Gooz, Shikhar Mehrotra, Eduardo N. Maldonado 463-pos Board B284 ROLE OF VDAC ISOFORMS IN BIOENERGETICS AND METABOLISM. Megha Rajendran , Sergey M. Bezrukov, Tatiana K. Rostovtseva 464-pos Board B285 DEFINING THE ROLES AND REGULATION OF THE MITOCHONDRIAL VDAC ISOFORMS ONE MOLECULE AT A TIME. WilliamM. Rosencrans , Maria Queralt-Martin, Henry J. Lessen, Motahareh Ghahari Larimi, Megha Ra jendran, Tsui-Fen Chou, Radhakrishnan Mahalakshmi, Alexander J. Sodt, Tsyr-Yan Yu, Sergey M. Bezrukov, Tatiana K. Rostovtseva 465-pos Board B286 COOPERATIVITY OF GATING OF ATP SYNTHASE AND ANT ION CHAN NELS. Elizabeth A. Jonas , Feifei Shang, Lei Shen, Nelli Mnatsakanyan 466-pos Board B287 IN ORGANELLO REAL-TIME NMR METABOLOMICS OF MITOCHONDRIA: AN S. CEREVISIAE MODEL OF BARTH SYNDROME DISPLAYS PERTURBED METABOLISM. Antonio J. Rua, Wayne Mitchell, Nathan N. Alder, Andrei T. Alexandrescu 462-pos

467-pos Board B288 CALCIUM AND BICARBONATE SIGNALING CONTROL MITOCHONDRIAL ATP PRODUCTION. Maura Greiser, Mariusz Karbowski, Aaron D. Kaplan, Andrew Coleman, Carmen A. Mannella, W. Jonathan Lederer , Liron Boy man 468-pos Board B289 BCL-2 EXPRESSION STIMULATES ETHANOL PRODUCTION IN YEAST. Laurent M. Dejean , Hailie Willey, Carlos Gonzalez, Sean Carpenter, An drew Gilbert, Krish Krishnan, Stephen Manon 469-pos Board B290 PRESSURE TREATMENT HAS A DIFFERENTIAL EFFECT ON CYANIDE- AND ETHANOL-INDUCED AUTOFLUORESCENCE RESPONSE IN YEAST. Xavier J. Mleziva, Paul K. Urayama 470-pos Board B291 PATHOLOGICAL ROLE OF HIGH SUGAR IN MITOCHONDRIAL RESPIRA TORY CHAIN DEFECT - AUGMENTED MITOCHONDRIAL STRESS. Ebrima D. Cham , Mei-Jie Jou 471-pos Board B292 MITOCHONDRIAL ROS AS A REGULATOR OF SYNAPTIC FUNCTION. Irina Stavrovskaya, Bethany Kristi Morin, Pablo M. Peixoto 472-pos Board B293 ENZYMATIC DEPLETION OF MITOCHONDRIAL INORGANIC POLYPHOS PHATE INCREASES THE GENERATION OF REACTIVE OXYGEN SPECIES AND THE ACTIVITY OF THE PENTOSE PHOSPHATE PATHWAY IN MAMMALIAN CELLS. Vedangi D. Hambardikar 473-pos Board B294 Travel Award Winner DEPLETION OF MITOCHONDRIAL POLYP LEVELS INCREASE THE PHOS PHORYLATION OF AMPK PROTEIN AND COMPROMISES OXYGEN CON SUMPTION IN SH-SY5Y CELLS. Renata Torres da Costa , Matheus Moreira Perez, Ernest Scoma, Vedangi D. Hambardikar, Lindsey M. Riggs, Maria E. Solesio Torregrosa 474-pos Board B295 PRUNE REGULATES THE MEATBOLISM OF MAMMALIAN INORGANIC POLYPHOSPHATES AND BIOENERGETICS. Ernest Scoma 475-pos Board B296 ROLE OF INORGANIC POLYPHOSPHATES IN THE ACTIVATION OF AMPK IN MODELS OF ALZHEIMER’S DISEASE. Lindsey M. Riggs , Maria E. Solesio Torregrosa 476-pos Board B297 IMBALANCES IN MITOCHONDRIAL METABOLISM AND UNCOUPLING PROTEIN 2 IN POLICYSTIC KIDNEY DISEASE CELLS. Monika Gooz , Yujing Dang, YefimManevich, Anna-Liisa Nieminen, Darwin Bell, Eduardo N. Maldonado 477-pos Board B298 CYCLOPHILIN D INHIBITION RESCUES CARDIAC FUNCTION IN NEONATAL HYPOXIA. Jonathan Burris, Gisela Beutner, Ethan D. Cohen, Min Yee, Michael A. O’Reilly, George A. Porter 478-pos Board B299 BIOACTIVE FUMARATE IMPROVES CARDIAC FUNCTION AND EXPANDS LIFESPAN IN FRIEDRECH’S ATAXIA. Lili Salinas, Francisco Figueroa, Claire B. Montgomery, Phung N. Thai, Nipavan Chiamvimonvat, Sundeep Dugar, Somdutta Sen, Gino Cortopassi, Elena N. Dedkova 479-pos Board B300 CONSEQUENTIAL MODULATION OF MITOCHONDRIAL K + - AND H + -DRIVEN ATP SYNTHASE ACTIVITY UNDER EXCESS CYTOPLASMIC NA + AND OXIDA TIVE STRESS MIMICKING HEART FAILURE: MODELING STUDIES. Sonia C. Cortassa , Miguel A. Aon, Magdalena Juhaszova, Dmitry B. Zorov, Steven J. Sollott

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