Biophysical Society 67th Annual Meeting Program Guide

794-plat 12:30 pm NONLINEAR COMPLIANCE OF NOMPC GATING SPRING AND ITS IMPLI CATION IN MECHANOTRANSDUCTION. Yukun Wang, Peng Jin, Avinash Kumar, David Bulkley, Lily Y. Jan, Yifan Cheng, Yuh-Nung Jan, Yongli Zhang Platform Ion Channels, Pharmacology, and Disease 10:45 am - 12:45 pm, Room 6F Co-Chairs Stephan Pless, University of Copenhagen, Denmark Sandra Zakrzewska, University of California, San Francisco, USA 10:45 am UNRAVELLING THE FUNCTIONAL REGULATION OF THE NALCN SODIUM LEAK CHANNEL COMPLEX BY G PROTEIN-COUPLED RECEPTORS. Hendrik Harms , Stephan A. Pless 796-plat 11:00 am MEXILETINE BLOCK IN COMMON VARIANTS OF THE CARDIAC SODIUM CHANNEL. Martina Marras 797-plat 11:15 am UPREGULATION OF RYANODINE RECEPTOR-1 DEPENDENT CALCIUM SIGNALING CONTRIBUTES TO THE MALIGNANCE OF HIGH-GRADE SE ROUS OVARIAN CANCER (HGSOC). Kay-Pong D. Yip, Chi-Lam Au-Yeung, Li Zhang, Samuel C. Mok, James S.K. Sham 798-plat 11:30 am NANOBODY-MEDIATED MODULATION OF HCN1 CHANNELS IN EPILEP TIC DISORDERS. Roberta Castelli , Atiyeh Sadat Sharifzadeh, Alessandro Porro, Andrea Saponaro, Anna Moroni 799-plat 11:45 am KV1.3 AS A THERAPEUTIC TARGET FOR IMMUNOCYTOPROTECTION AFTER REPERFUSION IN ISCHEMIC STROKE. Heike Wulff , Yi-Je Chen, Ruth D. Lee, Yanjun Cui, Latika Singh 800 -plat 12:00 pm Travel Award Winner A CELLULAR METABOLITE DIRECTLY AND REVERSIBLY OPENS THE ATP RELEASE PANNEXIN CHANNELS. Erik K. Henze , Toshimitsu Kawate 801-plat 12:15 pm CRYO-EM INVESTIGATION OF THE SUBCONDUCTANCE STATE OF RYANO DINE RECEPTOR CALCIUM RELEASE CHANNELS INDUCED BY SCORPION TOXINS. Filip Van Petegem , Omid Haji-Ghassemi, Yu Chen, Kellie Woll, Carmen R. Valdivia, Georgina B. Gurrola, Wenxuan Cai, Songhua Li, Hec tor H. Valdivia 802-plat 12:30 pm DEFINITION OF A SAXITOXIN (STX) BINDING CODE ENABLES DISCOVERY AND CHARACTERIZATION OF THE ANURAN SAXIPHILIN FAMILY. Sandra Zakrzewska , Zhou Chen, Holly S. Hajare, Aurora Alvarez-Buylla, Fayal Abderemane-Ali, Maximiliana Bogan, Dave Ramirez, Lauren A. O’Connell, Justin Du Bois, Daniel L. Minor 795-plat

783-plat 11:45 am FOLDING STABILITY AT THE ANION-BINDING SITE DISTINGUISHES PRESTIN FROM OTHER SLC26 TRANSPORTERS AS REVEALED BY HDX-MS. Xiaoxu an Lin , Patrick R. Haller, Navid Bavi, Nabil Faruk, Eduardo Perozo, Tobin R. Sosnick 784-plat 12:00 pm STATE-SPECIFIC MORPHOLOGICAL DEFORMATIONS OF THE LIPID BILAYER EXPLAIN MECHANOSENSITIVE GATING OF MSCS ION CHANNELS. Yein C. Park , Bharat Reddy, Navid Bavi, Eduardo Perozo, José D. Faraldo-Gómez 785-plat 12:15 pm A SEARCH FOR THE RESTING CONFORMATION OF THE BACTERIAL MECHANOSENSITIVE CHANNEL MSCS. Elissa Moller , Madolyn Britt, Andriy Anishkin, Doreen Matthies, Sergei Sukharev 786-plat 12:30 pm MECHANOSENSITIVE ION CHANNEL PIEZO1 AND RARE GENETIC DISOR DERS. Ruhma Syeda Platform Membrane Protein Dynamics I 10:45 am - 12:45 pm, Room 6E Co-Chairs NEGATIVE ALLOSTERIC MODULATION OF THE GLUCAGON RECEPTOR BY RAMP2. Evan S. O’Brien , Kaavya Krishna Kumar, Chris Habrian, Naomi R. Latorraca, Haoqing Wang, Inga Tuneew, Elizabeth Montabana, Susan Marqusee, Daniel Hilger, Ehud Y. Isacoff, Jesper M. Mathiesen, Brian K. Kobilka 788-plat 11:00 am ULTRAFAST STRUCTURAL CHANGES DIRECT THE FIRST MOLECULAR EVENTS OF RETINAL ISOMERISATION AND RHODOPSIN ACTIVATION. Gebhard F.X. Schertler 789-plat 11:15 am PHOTOACTIVATED LOCALIZATION MICROSCOPY COMBINED WITH IM AGE SPATIAL CORRELATION ANALYSIS TO STUDY OF THE DISTRIBUTION AND DIFFUSION OF ANGIOTENSIN II TYPE 1 RECEPTOR IN THE PLASMA MEMBRANE. Yenisleidy D.L.M. Zulueta Diaz , Camilla B. Andersen, Jakob L. Kure, Mathias H. Eriksen, Adam L. Lovatt, B. Christoffer Lagerholm, Sebastian V. Morales, Simon Sehayek, Paul W. Wiseman, Eva C. Arnspang 790-plat 11:30 am RESOLVING PROTEIN CONFORMATIONAL ENSEMBLES USING 19F-NMR AND CRYO-EM. Yun Huang 791-plat 11:45 am PRESSURE RESOLVED DEER TO DEFINE THE CONFORMATIONAL LAND SCAPE GOVERNING LIGAND-MEDIATED Β2-ADRENERGIC RECEPTOR SIGNAL TRANSDUCTION. Patrick Brennan 792-plat 12:00 pm UNRAVELING THE KEY-LOCK INTERACTION MECHANISMS OF THE HU MAN NEUROPEPTIDE Y TYPE 4 RECEPTOR (HY 4 R) VIA SOLID-STATE NMR SPECTROSCOPY. Marta Gozzi , Daniel Huster 793-plat 12:15 pm Travel Award Winner CONFORMATION-DEPENDENT DIFFUSION PROPERTIES OF A TRANSMEM BRANE PROTEIN. Raju Regmi , Titouan Gressier, Brieuc Chauvin, Alicia Damm, John Manzi, Manuela Dezi, Daniel Levy, Patricia M. Bassereau Marta Gozzi, Leipzig University, Germany Gebhard Schertler, ETH Zürich, Switzerland 787-plat 10:45 am

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