Biophysical Society 67th Annual Meeting Program Guide

Symposium Opportunities for Change: Setting Standards to Address Harassment in Science 10:45 am - 12:45 pm, Room 6A Toxic work environments where bullying, harassment and bad behavior are allowed to persist create unsafe environments for staff and students. Unchecked, this can lead to physical and mental health safety issues, underperformance and ultimately contributes to highly talented people leaving the research/science sector, particularly those from historically underrepresented groups. This session will be a forum where leaders from national funding agencies and diversity and inclusion accreditation bodies will discuss their role in driving institutional culture change in creating an inclusive scientific climate. We will hear from representatives from the NIH, the NSF, and gender equity, diversity and inclusion accreditation bodies in Australia (SAGE) and the USA (SEA Change). Chair Renae Ryan, University of Sydney, Australia Speakers with panel discussion Renae Ryan, University of Sydney, Australia Chair Elizabeth Hinde, University of Melbourne, Australia No Abstract 10:45 am AN INTEGRATED MECHANO-RESPONSE MEDIATED BY ATR AND ATM. Marco Foiani 768-symp 11:15 am MOLECULAR TAKE ON PHASE SEPARATION OF FUS. Sua Myong , Kevin Rhine, Joey Yoniles, Morgan Dasovich, Mohsen Badiee, Sophie Skanchy, Laura Ganser, Yingda Ge, Charlotte Fare, James Shorter, Anthony K. Leung 769-symp 11:45 am MANIPULATE SINGLE NUCLEIC ACID MOLECULES IN LIVE CELLS. Shuaixin He, Lauren Blake, Yang Liu, Taekjip Ha, Bin Wu 770-symp 12:15 pm HISTONE FRET MICROSCOPY OF LIVE CELL GENOME ARCHITECTURE. Elizabeth Hinde Platform Condensates: Physical Properties and Modeling I 10:45 am - 12:45 pm, Room 6C Co-Chairs Sze Ham Chan, University of Virginia, USA Hue Sun Chan, University of Toronto, Canada 771-plat 10:45 am A UNIVERSAL CODE FOR PHASE SEPARATION OF PRION-LIKE LOW COM PLEXITY DOMAINS: INSIGHTS FROM QUANTITATIVE COMPUTER SIMULA TIONS. Maria Julia Maristany , Anne Aguirre, Jerelle A. Joseph, Rosana Collepardo-Guevara Michael Lauer, NIH, USA Theresa Good, NSF, USA Beth Reudi, AAAS, (SEA Change), USA Symposium Genome Organization 10:45 am - 12:45 pm, Room 6B

772-plat 11:00 am ELUCIDATING THE DYNAMICS OF INDIVIDUAL IDPS IN A BIOMOLECULAR CONDENSATE USING SINGLE-MOLECULE FRET AND MOLECULAR SIMULA TION. Miloš T. Ivanovic , Nicola Galvanetto, Aritra Chowdhury, Andrea Sottini, Mark F. Nüesch, Daniel Nettels, Robert B. Best, Benjamin Schuler 773-plat 11:15 am MUTUAL REGULATION BETWEEN MEMBRANE RAFTS AND PROTEIN CON DENSATES IN T CELL ACTIVATION. Sze Ham Chan , Hongyin Wang, Simli Dey, Ivan Castello-Serrano, Jonathon A. Ditlev, Michael K. Rosen, Kandice R. Levental, Ilya Levental 774-plat 11:30 am CHARACTERIZING PROTEIN INTERACTIONS IN BIOMOLECULAR PHASE SEPARATION. Hannes Ausserwöger , Georg Krainer, Daoyuan Qian, Timo thy Welsh, Tomas Sneideris, Matthias M. Schneider, Gaetano Invernizzi, Therese W. Herling, Nikolai Lorenzen, Tuomas P. Knowles 775-plat 11:45 am DYNAMICS OF BACTERIAL RIBONUCLEOPROTEIN BODIES PROBED BY SINGLE-MOLECULE FLUORESCENCE IMAGING OF RNASE E. Luis A. Ortiz Rodriguez , Christopher A. Azaldegui, Jared Schrader, Julie Biteen 776-plat 12:00 pm ELECTROSTATICS OF SALT-DEPENDENT RE-ENTRANT PHASE BEHAVIORS HIGHLIGHTS DIVERSE ROLES OF ATP IN BIOMOLECULAR CONDENSATES. Yi-Hsuan Lin, Tae Hun Kim, Suman Das, Tanmoy Pal, Jonas Wessen, Lewis E. Kay, Julie D. Forman-Kay, Hue Sun Chan 777-plat 12:15 pm THE IMPACT OF GRB2 ON PHASE CONDENSATION IN LIVE CELLS. Brittany Stinger , Chun-Wei Lin, Henry T. Phan, Kiera B. Wilhelm, Anand Vissa, Jay Travel Award Winner COMPLEX COACERVATION CONTRIBUTES TO THE JOINT PHASE BEHAV IORS OF MIXTURES OF CHARGE-DEFICIENT PRION-LIKE LOW-COMPLEXITY DOMAINS. Mina Farag , Anne Bremer, Wade M. Borcherds, Tanja Mittag, Rohit V. Pappu Platform Member Organized Session: Mechanosensitive Membane Proteins 10:45 am - 12:45 pm, Room 6D Co-Chairs Charles Cox, The Victor Chang Cardiac Research Institute, Australia Jerome Lacroix, Western University, USA 779-plat 10:45 am EICOSAPENTAENOIC ACID ENHANCES PIEZO2 INACTIVATION AND COUNTERACTS PIEZO2 GAIN OF FUNCTION MUTATIONS. Luis O. Romero , Shang Ma, Adrienne E. Dubin, Meaghan Loud, Alexandra Salazar, Yu Wang, Alexander T. Chesler, Katherine Wilkinson, Kara L. Marshall, Ardem Patapoutian, Valeria Vasquez 780-plat 11:00 am FORCE-SENSING IN PIEZO ION CHANNELS. Christoph Haselwandter 781-plat 11:15 am PIEZO1 ACTIVATES NON-CANONICAL EGFR INTERNALIZATION AND SIG NALING. Carlos Pardo-Pastor , Jody Rosenblatt 782-plat 11:30 am HOW DOES FAST-INACTIVATION PIEZO1 CHANNEL SENSE CONSTANT MECHANICAL FORCES IN NATIVE ENDOTHELIAL CELLS? Jian Shi T. Groves 778-plat 12:30 pm

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