Biophysical Society Bulletin | December 2024

Thematic Meeting

Emerging Theoretical Approaches to Complement Single-Particle Cryo-Electron Microscopy

Trieste, Italy, October 21–25, 2024 The field of biophysics is experiencing a remarkable shift, fueled by pioneering advances in cryo-electron microscopy (cryo-EM) complemented by groundbreaking advances in computational methodologies. The recent Biophysical Society Thematic Meeting gathered global experts to address critical challenges in processing, validating, and interpreting cryo EM data, and how best to apply computational modeling and simulations to complement experimental findings. The field of computational biophysics serves as a cornerstone of structural biology, which continues to give rise to meth ods for generating interpretable atomic and dynamic models from experimental structural data. This meeting emphasized this essential role of computational biophysics in structur al biology, as it united leaders in cryo-EM technology and computational science, focusing on advanced data-processing techniques and the complex dynamics of large biomolecules visualized via cryo-EM. Sessions also covered the latest de velopments in electron tomography and multiscale modeling, which allows for unprecedented detail of cellular components, their interactions, and their regulation.

More than 80 participants from around the globe gathered in the beautiful city of Trieste, Italy, a cultural crossroad of Mediterranean, Central European, and Eastern European her itage. The location at the International School for Advanced Studies (SISSA), a highly regarded biophysics research hub, provided an inspiring backdrop for this collaborative event. The scientific diversity of the presentations and the intimate setting fostered enthusiastic conversations about the need for methodological advancements, especially in validation and reproducibility within cryo-EM research, underscoring the collaborative push to enhance single-particle cryo-EM appli cations and associated simulations. The meeting was notable for its geographic, gender, dis ciplinary, and background diversity, with participants from North and South America, Europe, and Asia. There were 21 invited speakers, 14 short talks (pulled from submitted abstracts), and 29 posters showcasing the creativity of the community, with representation from 17 countries: Australia, Canada, China, Czech Republic, France, Germany, India, Italy, Japan, Poland, Singapore, Slovenia, South Africa, Spain,

December 2024

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