Biophysical Society Thematic Meeting | Canterbury 2023

Towards a More Perfect Union: Multi-Scale Models of Muscle and Their Experimental Validation

Daily Schedule

Towards a More Perfect Union: Multi-Scale Models of Muscle and Their Experimental Validation Canterbury, England July 17—20, 2023 All scientific sessions will be held in the Sibson Building at the University of Kent Lecture Hall SIB L2, unless otherwise noted. PROGRAM

Monday, July 17, 2023

7:45 – 20:00

Registration/Information

Sibson Foyer

8:15 – 8:30

Michael Regnier, University of Washington, USA Michael Geeves, University of Kent, United Kingdom Welcome and Opening Remarks MD/BS Simulations of Myofilament Proteins Co-Chairs: Anne Houdusse, Institut Curie, France

Session I

Matthew Childers, University of Washington, USA

8:30 – 8:50

Anne Houdusse, Institut Curie, France Small Molecules Modulating Force Production: A New Perspective Against Muscle-Associated Diseases Matthew Childers, University of Washington, USA Using 2’-Deoxy-ADP to Probe Stability of the Myosin Interacting Heads Motif at Atomic Resolution Ian Gould, Imperial College, United Kingdom An In-Silico Investigation of the Effects of Small Molecules that Restore the Effects of Phosphorylation to Uncoupled Thin Filaments due to Cardiomyopathy causing TNC G1590D Mutation Michael Rynkiewicz, Boston University, USA Modeling the Troponin Core Domain on Thin Filaments Using Data from Cryoelectron Microscopy and Fluorescence Approaches Brett Colson, University of Arizona, USA* Hypertrophic Cardiomyopathy Mutations in Cardiac Myosin-Binding Protein CN-Terminal Domains Cause Local and Allosteric Effects on Protein Mobility and Increase Actin Binding

8:50 – 9:10

9:10 – 9:30

9:30 – 9:50

9:50 – 10:00

10:00 – 10:30

Coffee Break

Sibson Foyer

Session II

Integrating Computational Models at Different Spatial and Temporal Scales Co-Chairs: Daniela Valdez-Jasso, University of California, San Diego, USA Joseph Powers, University of Washington, USA

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