Biophysical Society Thematic Meeting | Canterbury 2023

Towards a More Perfect Union: Multi-Scale Models of Muscle and Their Experimental Validation

Daily Schedule

10:30 – 10:50

Daniela Valdez-Jasso, University of California, San Diego, USA Multi-scale Modeling for Determining Sex Differences in Resting and Active Myocardial Material Properties in a Rat PAH Model Joseph Powers, University of Washington, USA Integrating Multiscale Computational Models and Experimental Biomechanics to Investigate the Contractility Filamin C Deficient Hearts Srba Mijailovich, Filamentech, USA Integration of Multiple Experiments by Multiscale Computational Modeling Kyoko Yoshida, University of Minnesota, USA Multiscale Model Predictions of Heart Growth Applied to Postpartum and Hypertensive Pregnancies Amadeus Gebauer, Technical University of Munich, Germany* A Constrained Mixture Model of Sarcomere Turnover in Cardiomyocytes for Organ-Scale Cardiac Growth and Remodeling

10:50 – 11:10

11:10 – 11:30

11:30 – 11:50

11:50 – 12:00

12:00 – 13:00

Lunch

Sibson Foyer

Do We Have an Accurate Measure of Ca 2+ Transients – Does it Matter? Co-Chairs: Ana Maria Gomez, INSERM, France Josine deWinter, Amsterdam, UMC, The Netherlands

Session III

13:00 – 13:20

Ana Marie Gomez, INSERM, France CA 2+ Dynamics in Cardiac Pathological Models Josine deWinter, Amsterdam UMC, The Netherlands KBTBD13 is a Novel Cardiomyopathy Gene

13:20 – 13:40

13:40 – 14:00

Corrado Poggesi, University of Florence, Italy Excitation-Contraction Coupling Alterations in Hypertrophic Cardiomyopathy and Arrhythmia Propensity Leonardo Sacconi, European Laboratory for Non-Linear Spectroscopy, Italy Correlating Electrical Disfunction and Structural Remodeling in Arrhythmogenic Mouse Hearts by Advanced Optical Methods. Sage Malingen, University of Washington, USA* Molecular Dynamics Simulations Reveal Functional Changes in Troponin Resulting from Mutations Implicated in Cardiomyopathies W hat’s New in Thin Filament Regulation and What Cryo-EM Doesn’t Tell Us Co-chairs: Jil Tardiff, The University of Arizona, USA Ivanka Sevrieva, King’s College of London, United Kingdom Jil Tardiff, The University of Arizona, USA Walking a Thin (Filament) Line: Integrating Time-Resolved Fret and Computation to Identify Novel Pathogenic Mechanisms in Hypertrophic Cardiomyopathy Coffee Break Sibson Foyer

14:00 – 14:20

14:20 – 14:30

14:30 – 15:00

Session IV

15:00 – 15:20

5