Biophysical Society Thematic Meeting | Canterbury 2023

Towards a More Perfect Union: Multi-Scale Models of Muscle and Their Experimental Validation

Daily Schedule

15:20 – 15:40

Ivanka Sevrieva, Kings College London, United Kingdom Comparison of the Cardiac Troponin Conformation Determined by Polarized Fluorescence and Cryo-EM William Lehman, Boston University, USA TROPONIN-I Induced Tropomyosin Pivoting Defines Cardiac Thin Filament Structure in Relaxed Muscle

15:40 –16:00

16:00 – 16:20

Yuichiro Maeda, Okayama University, Japan Structures and Mechanisms of Actin ATP Hydrolysis

16:20 – 16:30

Joseph Chalovich, ECU Brody School of Medicine, USA* The Unstructured C-Terminal Region of Troponin T Retards Calcium Activation of Striated Muscle

16:30 – 18:00

Poster Session

Sibson Foyer

18:00 – 18:45

Keynote Address Steven Schwartz, The University of Arizona, USA Model Building Challenges and the Time-Scale Problem in the Computational Study of Muscle Biophysics

18:45

Reception

Keynes/K-Bar

Tuesday, July 18, 2023 8:15 – 14:45

Registration/Information

Sibson Foyer

8:15 – 9:00

Keynote Address Leslie Leinwand, University of Colorado, USA Multiscale Regulation of Sarcomeres in Health and Disease What do Modelers Need from Experimentalists and Vice Versa? Chair: Malcolm Irving, Kings College London, United Kingdom Stuart Campbell, Yale University, USA Predicting Clinical Phenotypes of TPM1 Missense Mutations Martin Pfaller, Stanford University, USA FSGE: A Computational Model for Equilibrated Cardiovascular Fluid-Solid-Growth Interaction Panel Discussion Chair: Malcolm Irving, King’s College London, United Kingdom

Session V

9:00 – 9:15

9:15 – 9:30

9:30 – 10:30

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