Biophysical Society Thematic Meeting | Canterbury 2023

Towards a More Perfect Union: Multi-Scale Models of Muscle and Their Experimental Validation

Daily Schedule

10:30 – 10:45

Coffee Break

Sibson Foyer

Session VI

Small Molecule Therapeutics for Muscle Disease Chair: Michael Regnier, University of Washington, USA

10:45 –11:05

Michael Regnier, University of Washington, USA Experimental and Computational Approaches for Mechanistic Analysis and Therapeutic Development of 2-Deoxy ATP to Treat Heart Failure Allan Russell, Edgewise Therapeutics, USA Modulating Fast Skeletal Muscle Contraction as a Novel Strategy for the Protection of Skeletal Muscle in Muscular Dystrophy James Hartman, Cytokinetics, USA Preclinical Characterization of CK-4021586, A New Class of Cardiac Myosin Inhibitors for the Treatment of Hypertrophic Cardiomyopathy

11:05 – 11:25

11:25 – 11:40

11:40 – 12:00

Andras Malnasi-Csizmadia, Evötös Loránd University, Hungary Drug Design Targeting Myosin Blebbistatin Binding Site

12:00 – 12:10

Marcus Hock, University of California, San Diego, USA* Multiscale Simulations of the Effects of 2’-Deoxy-ATP and Myosin Mutations on Actomyosin Interactions

12:15 – 13:15

Lunch

Sibson Foyer

13:15 – 14:45

Poster Session II

Sibson Foyer

Wednesday, July 19, 2023

8:00 – 18:00

Registration/Information

Sibson Foyer

8:15 – 8:45

Keynote Address Elisabetta Brunello, King’s College of London, United Kingdom Structural Dynamics of the Thick Filament During the Physiological Cardiac Cycle What’s New in Thick Filament Regulation Co-Chairs: Samantha Harris, The University of Arizona, USA Christopher Toepfer, University of Oxford, United Kingdom Samantha Harris, The University of Arizona, USA Cut and Paste of Myosin Binding Protein-C in Skeletal Muscles Christopher Toepfer, University of Oxford, United Kingdom Understanding Hypertrophic Cardiomyopathy (Hcm) Across the Thick and Thin Filament, Bridging In-Vitro and In-Silico Models of Disease to Accelerate Pathomechanism Discovery

Session VII

8:45 – 9:05

9:05 – 9:25

9:25 – 9:45

Thomas Irving, Illinois Institute of Technology, USA Myosin Based Regulation: The Plot Thickens

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