Biophysical Society Thematic Meeting | Canterbury 2023

Towards a More Perfect Union: Multi-Scale Models of Muscle and Their Experimental Validation

Daily Schedule

9:45 – 10:05

Neil Kad, University of Kent, United Kingdom Single Molecule Imaging Approaches Towards Understanding Dual Filament Regulation in Muscle Charles Chung, Wayne State University, USA* Ramp-Stretches During Relaxation of Twitching Intact Cardiac Traecula Suggest a Need for Dynamic Models of Myofilament Function Cross-Bridge Recruitment and Dynamics: New and Unresolved Questions Co-chairs: Michael Geeves, University of Kent, United Kingdom Manta Amrute Nayak, Medical School of Hanover, Germany Michael Geeves, University of Kent, United Kingdom Are the DRX and SRX States in Thermal Equilibrium a Paradox? Mamta Amrute-Nayak, Medical School of Hanover, Germany Evidence for Two Distinct Actomyosin Cross-Bridge Stiffness for Human Beta Cardiac Myosin David Warshaw, University of Vermont, USA Myosin-Binding Protein C/H: Impact on Muscle Contractility and Development Edward DeBold, University of Massachusetts, USA Recent Biophysical Approaches to Investigate the Coupling Between Force Generation and Phosphate-Release in Myosin Matvey Pilagov, University of Kent, United Kingdom* Super-Resolution Single-Molecule Imaging of ATP Usage in Myofibrils to Study Thick Filament Regulation What is on the Horizon from Modellers and Experimentalists? Chair: Andrew McCulloch, University of California San Diego, USA Andrew McCulloch, University of California, San Diego, USA Multi-Scale Modeling of Biophysics: From Molecules to Populations Farah Sheikh, University of California, San Diego, USA Connexin43 Restoration Alleviates End-Stage Alterations in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Panel Discussion Chair Andrew McCulloch, University of California, San Diego, US Coffee Break Sibson Foyer Lunch Sibson Foyer

10:05 – 10:15

10:15 – 10:45

Session VIII

10:45 – 11:05

11:05 – 11:25

11:25 – 11:45

11:45 – 12:05

12:05 – 12:15

12:15 – 13:15

Session IX

13:15 – 13:30

13:30 – 13:45

13:45 – 14:30

14:30 – 15:00

Coffee Break

Sibson Foyer

Session X

Passive Tension in Muscle Cells: Protein Players and Plasticity Co-chairs: Jolanda Van der Veldon, Amsterdam University Matthew Caporizzo, University of Vermont, USA

15:00 – 15:20

Jolanda Van der Veldon, Amsterdam University, The Netherlands Modulators of Cardiac Muscle Relaxation and their Role in Cardiac Pathology

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