Biophysical Society Thematic Meeting | Canterbury 2023

Towards a More Perfect Union: Multi-Scale Models of Muscle and Their Experimental Validation

Daily Schedule

15:20 – 15:40

Matthew Caporizzo, University of Vermont, USA Microtubules are Viscous Regulators of Myocardial Motion Michael Gotthardt, Max Delbruck Center, Germany Regulating Titin Based Stiffness in Health and Disease Jennifer Davis, University of Washington, USA Fibroblast-Mediated Regulation of Cardiac Structure and Stiffness Bradley Palmer, University of Vermont, USA* Contribution of Thick Filament Stiffness to Length Dependent Activation in Cardiac Muscle

15:40 – 16:00

16:00 – 16:20

16:20 – 16:30

16:30 – 18:00

Poster Session III

Sibson Foyer

18 :30

Dinner Banquet

Socialite Restaurant

Thursday, July 20, 2023

8:00 – 12:45

Information

Sibson Foyer

8:15 – 8:45

Keynote Address Thomas Daniel, University of Washington, USA Multiscale Models of Muscle Melding Molecular and Myofilament Levels of Organization Sarcomere and Muscle Cell Models of Contractile Dynamics Co-chairs: Kenneth Campbell, University of Kentucky, USA Cheavar Blair, University of California, Santa Barbara, USA

Session XI

8:45 – 9:05

Kenneth Campbell, University of Kentucky, USA Multiscale Modeling of Pathological Cardiac Growth

9:05 – 9:25

Cheavar Blair, University of California, Santa Barbara, USA Sarcomere Dynamics Simulation to Uncover Mechanisms in Hypertrophic Cardiomyopathy Michael Greenberg, Washington University in St. Louis, USA Harnessing Multiscale Models to Understand Dilated Cardiomyopathy Thin Filament Mutations Farid Moussavi-Harami, University of Washington, USA Machine Learning for Building Classifiers and Rate Estimates in Simulated Twitches Howard White, Eastern Virginia Medical Center Physiological Sciences, USA* Structure of Prepowerstroke Actomyosin by Cryoelectronmicroscopy at 10MD and 5A

9:25 – 9:45

9:45 – 10:05

10:05 – 10:15

10:15 – 10:45

Coffee Break

Sibson Foyer

9