Program Book

8:15 am –10:15 am , R oom 135 Symposium Mechanosensing in Eukaryotes

Tuesday, February 18 7:30 am –5:00 pm , N orth L obby Registration/Information 7:30 am –10:00 pm , R oom 112 Family Room 8:00 am –9:00 am , R oom 302 Biophysical Society Business Meeting

Co-Chairs Jeffrey Holt, Harvard University & Boston Children’s Hospital Valeria Vasquez, Stanford University 2140-S ymp 8:15 am

ZEN AND THE ART OF MECHANOSENSATION: HOW MSCS- LIKE MECHANOSENSITIVE CHANNELS HELP EUKARYOTIC CELLS AND ORGANELLES REDUCE STRESS. Elizabeth Haswell , Kira Veley, Grigory Maksaev, Margaret Wilson, Gregory Jensen, Eric Hamilton 2141-S ymp 8:45 am MAY THE FORCE BE WITH YOU: SEARCH FOR ION CHANNELS THAT RESPOND TO PRESSURE. Ardem Patapoutian 2142-S ymp 9:15 am TOUCH AS A MATTER OF FAT: THE PHOSPHOLIPIDS AND DEG/ENAC CHANNELS NEEDED FOR METAZOAN TOUCH SENSATION. Miriam B. Goodman 2143-S ymp 9:45 am TMC FUNCTION IN HAIR CELL MECHANOTRANSDUCTION. Jeffrey R. Holt

The annual business meeting is open to all Society members. 8:00 am –4:30 pm , H all D Poster Viewing 8:00 am –5:30 pm , R oom 300 Career Center

8:00 am –6:00 pm , M arriott M arquis , P acific H, I, J Child Care 8:00 am –6:00 pm , R otunda , 300 L evel Undergraduate Student Lounge

8:15 am –10:15 am , R oom 130/131 Platform Cell Mechanics and Motility III

This special space is reserved for undergraduate meeting attendees looking for a place to relax or catch up on coursework they may be missing while at the Annual Meeting. Members of the Education Committee, which sponsors this lounge, will stop by to answer questions student attendees may have about career paths and opportunities. 8:15 am –10:15 am , R oom 134 Symposium Biophysics in Industry: Putting Evolution in Practice Co-Chairs Kenneth Dill, Stony Brook University Timothy Gardner, Amyris, Inc. 2137-S ymp 8:15 am TRANSFORMING YEAST FROM MOONSHINERS INTO OIL BARONS. Timothy Gardner N o A bstract 8:45 am SYNTHETIC BIOLOGY. Christopher Voigt 2138-S ymp 9:15 am HARNESSING NATURE’S DIVERSITY FOR PRODUCTION OF UNIQUE TRIGLYCERIDE OILS. Peter Licari 2139-S ymp 9:45 am PHYSICAL CONSTRAINTS ON PROTEOMES IMPOSE LIMITS TO BIOLOGICAL EVOLUTION. Kenneth Dill

Co-Chairs Hedde van Hoorn, Leiden University, The Netherlands Lene Oddershede, University of Copenhagen, Denmark 2144-P lat 8:15 am

THE PREDOMINANT ROLE OF TENSION IN THE NANOSCALE MECHANICAL BEHAVIOR OF CELLS VISUALIZED BY A NEW IMAGING PLATFORM. Nicola Mandriota, Ozgur Sahin 2145-P lat 8:30 am INVESTIGATING FOCAL ADHESION MECHANICS USING NANOPATTERNED MOLECULAR TENSION FLUORESCENCE MICROSCOPY (MTFM). Yang Liu , Rebecca Medda, Elisabetta Ada Cavalcanti-Adam, Khalid Salaita 2146-P lat 8:45 am PROBING THE MECHANICAL COUPLING OF THE CELL MEMBRANE TO THE NUCLEUS WITH VERTICAL NANOPILLAR ARRAYS. Lindsey Hanson , Wenting Zhao, Ziliang Lin, Yi Cui, Bianxiao Cui 2147-P lat 9:00 am OUTWARD MICROTUBULE-MEDIATED PUSHING FORCES DICTATE MITOSIS. Hedde van Hoorn , Martin de Valois, Claude Backendorf, Thomas Schmidt 2148-P lat 9:15 am ANALYSIS AND MODELING OF DENDRITIC SPINE MORPHO- GENESIS. Olena Marchenko , Charles W. Wolgemuth, Leslie M. Loew 2149-P lat 9:30 am TRACTION FORCE MICROSCOPY BASED ON AN ACTIVE CA- BLE NETWORK MODEL. Jerome Soine, Christoph Brand, Jonathan Stricker, Patrick W. Oakes, Margaret L. Gardel, Ulrich S. Schwarz 2150-P lat 9:45 am MIGRATION, FORCE GENERATION AND MECHANOSENSING OF CELLS IN COLLAGEN GELS. Julian Steinwachs , Claus Metzner, Katerina Aifantis, Ben Fabry

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Biophysical Society 58 th Annual Meeting, San Francisco, California