Program Book

2226-P lat 12:15 pm OBSERVING TAUTOMERIZATION OF A DEOXYCYTIDINE ANALOG KP1212: MOLECULAR ORIGIN OF LETHAL MUTAGENESIS AGAINST HIV. Chunte Sam Peng , Carlos Baiz, Mike Reppert, Deyu Li, Bogdan I. Fedeles, Vipender Singh, John M. Essigmann, Andrei Tokmakoff 2227-P lat 12:30 pm DNA SEQUENCING WITH PROTEIN NANOPORES: A STORY OF STRANDS AND NUCLEOTIDES. Syma Khalid , Andrew T. Guy, Richard Manara, Jayne Wallace 10:45 am –12:45 pm , R oom 305 Platform Membrane-Active Peptides and Toxins Co-Chairs Burkhard Bechinger, University of Strasbourg/CNRS, France Shirley Schreier, University of Sao Paulo, Brazil 2228-P lat 10:45 am LIPID-MEDIATED POLYPEPTIDE INTERACTIONS INMEMBRANES: CASE STUDY ONTHE SYNERGISM BETWEEN LINEAR CATIONIC ANTIMICROBIAL PEPTIDES. Evgeniy S. Salnikov, Elise Glattard, Hiba Sarrouj, Arnaud Marquette, Christopher Aisenbrey, Olivier Ouari, Paul Tordo, Frank Engelke, Fabien Aussenac, Burkhard Bechinger 2229-P lat 11:00 am education travel awardee MULTISCALE SIMULATIONS OF DIPHTHERIA TOXIN T-DO- MAIN MEMBRANE ASSOCIATION. Jose C. Flores-Canales , Alexey S. Ladokhin, Maria Kurnikova 2230-P lat 11:15 am PEPTIDE:LIPID RATIO AND MEMBRANE SURFACE CHARGE MODULATE THE MECHANISM OF ACTION OF THE ANTIMICROBIAL PEPTIDE BP100. Shirley Schreier , Mariana C. Manzini, Katia R. Perez, Karin A. Riske, José C. Bozelli JR, Mario J. Politi, Ana P. Valente, Fabio C. Almeida, Hernan Chaimovich, Magali A. Rodrigues, Marcelo P. Bemquerer, Iolanda M. Cuccovia 2231-P lat 11:30 am THE USE OF SURFACE PLASMON-BASED INFRARED SPECTROSCOPY TO DETECT INTERCELLULAR JUNCTIONS ALTERATIONS IN INFLAMED INTESTINAL CELLS. Amir Bein , Alexander Zilbershtein, Michael Golosovsky, Dan Davidov, Betty Schwartz 2232-P lat 11:45 am POINT MUTATION IN THE HYDROPHOBIC REGION DRIVES SELECTIVITY AND ACTIVITY OF OP-145, A DERIVATIVE OF HUMAN CATHELICIDIN LL-37. Nermina Malanovic , Jan Wouter Drijfhout, Manfred Kriechbaum, Maria Schmuck, Anna de Breij, Peter Nibbering, Karl Lohner 2233-P lat 12:00 pm LOCALIZED PERMEABILIZATION OF E. COLI MEMBRANES BY THE ANTIMICROBIAL PEPTIDE CECROPIN A. Nambirajan Rangarajan , Somenath Bakshi, James Carl Weisshaar 2234-P lat 12:15 pm DEVELOPMENT OF FUNCTIONAL ARTIFICIAL ION CHANNELS USING PEPTIDE NANOSTRUCTURES. Normand Voyer , François Otis, Eric Biron, Charles Racine-Berthiaume, Michèle Auger, Kyle Hartwick, Marise Ouellet 2235-P lat 12:30 pm SWITCHINGTHE ANTIMICROBIAL ACTIVITY OF GRAMICIDIN S BY LIGHT. Oleg Babii , Segrii Afonin, Marina Berditsch, Sabine Reisser, Thomas Steinbrecher, Pavel Mykhailiuk, Igor Komarov, Anne S. Ulrich

10:45 am –12:45 pm , R oom 306 Platform Microtubules and Motors

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Co-Chairs Jennifer Ross, University of Massachusetts, Amherst William Hancock, Pennsylvania State University 2236-P lat 10:45 am

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3.8 ANGSTROM RESOLUTION STRUCTURE OF MICROTUBULE BY CRYO-EM. Rui Zhang , Gregory Alushin, Elizabeth Kellogg, Eva Nogales 2237-P lat 11:00 am TUBULIN COFACTORS FORM A MULTI-PROTEIN PLATFORMS THAT REGULATE THE SOLUBLE TUBULIN POOL AND PROMOTE MICROTUBULE POLYMERIZATION. Stanley Nithianantham, Sinh Le, Shu Ti, Elbert Seto, Jawdat Al-Bassam 2238-P lat 11:15 am STRUCTURAL BASIS FOR NUCLEOTIDE EXCHANGE AND POWER STROKE GENERATION BY THE KINESINMOLECULAR MOTOR. Zhiguo Shang, Roseanne Csencsits, Chen Xu, Jared C. Cochran, Charles Vaughn Sindelar 2239-P lat 11:30 am BIMODALITY IN A SYSTEMOF ACTIVE AND PASSIVE KINESIN-1 MOTORS. Lara Scharrel , Rui Ma, Frank Jülicher, Stefan Diez 2240-P lat 11:45 am A COMPARATIVE STUDY OF THE MAJOR BIOCHEMICAL STATES OF KINESIN-MT COMPLEX USING COMPUTATIONAL TECHNIQUES AND ALL-ATOM STRUCTURAL MODELS. Srirupa Chakraborty , Wenjun Zheng 2241-P lat 12:00 pm SELF-REGULATION OF CYTOPLASMIC DYNEIN THROUGH ITS UNCONVENTIONAL FORCE RESPONSE. Takayuki Torisawa , Ken’ya Furuta, Akane Furuta, Muneyoshi Ichikawa, Kei Saito, Kazuhiro Oiwa, Hiroaki Kojima, Yoko Yano Toyoshima 2242-P lat 12:15 pm DYNEIN’S C-TERMINAL DOMAIN PLAYS A NOVEL ROLE IN REGULATING FORCE GENERATION. Peter Höök, Matthew P. Nicholas, Sibylle Brenner, Caitlin Lazar, Sarah J. Weil, Richard B. Vallee, Arne Gennerich 2243-P lat 12:30 pm REGULATORY PROTEINS ENABLE THE KINESIN KIP2 TO OVERPOWER CYTOPLASMIC DYNEIN. Anthony J. Roberts , Brian S. Goodman, Samara L. Reck-Peterson SURFE2R — Catch the Wave for Transporters. Precise Measurements of Membrane Transporter Protein Activity Ion transporters and pumps play an important role within general metabolism and information processing of organisms. Dysfunction and regulation of transporter proteins are related to diseases like obesity, diabe- tes, and hypertension, and CNS disorders such as epilepsy and depression. Hence, ion transporters have become potential targets within the drug development treating disease-related abnormalities. At present, labeling technologies and conventional patch clamp are commonly used for ion transporter screening. However, radioactive and fluorescence-based assays have limited sensitivity, and because of the limited molecule turnover per seconds of transporters and pumps compared to ion channels, the direct electrophysiological measurement of protein transporters and pumps ac- 11:00 am –12:30 pm , R oom 123 Exhibitor Presentation Nanion Technologies

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Biophysical Society 58 th Annual Meeting, San Francisco, California