Program Book

2214-P lat 11:15 am EXACT PARTITION FUNCTION ZEROS OF THE WAKO-SAITô- MUñOZ-EATON PROTEIN MODEL. Julian Lee 2215-P lat 11:30 am ALLOSTERIC COUPLING VIA COMMUNICATION OF DISTAL DISORDER-TO-ORDER TRANSITIONS. Dorothy Beckett , Christopher Eginton, Sharrol Bachas, Herschel Wade 2216-P lat 11:45 am RESHAPING ANTIBODY DIVERSITY. Damian C. Ekiert , Feng Wang, Ian A. Wilson, Peter G. Schultz, Vaughn V. Smider 2217-P lat 12:00 pm COMPUTING CONFORMATIONAL ENTROPY IN ANTIBODY INTERFACES. Pablo Gainza , Kyle E. Roberts, Mark A. Hallen, Bruce R. Donald 2218-P lat 12:15 pm CONTROLLING PROTEIN BINDING SPECIFICITY BY A CONFORMATIONAL SHIFT. Servaas Michielssens , Jan Henning Peters, David Ban, Supriya Pratihar, Stefan Becker, Thomas Michael Sabo, Karin Giller, Lee Donghan, Christian Griesinger, Bert de Groot 2219-P lat 12:30 pm REPROGRAMMING AN ATP-DRIVEN BIOLOGICAL MACHINE INTO A LIGHT-GATED PROTEIN NANOCAGE. Daniel Hoersch , Soung-Hun Roh, Wah Chiu, Tanja Kortemme

10:15 am –12:45 pm , R oom 132/133 Platform Voltage-gated K Channels: Mostly BK and Structure Function Co-Chairs Lawrence Salkoff, Washington University School of Medicine, St. Louis Ramón Latorre, University of Valparaíso, Chile 2204-P lat 10:15 am LOCATION OF BK ION PERMEATION GATE REVEALED BY CD 2+ -CYS COORDINATION IN THE BK INNER PORE REGION. Yu Zhou , Christopher Lingle 2205-P lat 10:30 am IDENTIFICATION OF A DISCRETE ALCOHOL-SENSING SITE IN THE BK (SLO1) CHANNEL. Anna Bukiya, Justin Edwards, Alex Dopico 2206-P lat 10:45 am BASELINE PROPERTIES OF SLO1 K + (BK) CHANNELS WITHOUT THE GATING RING. Yanyan Geng , Gonzalo Budelli, Alice Butler, Celia Santi, Juan Ferreira, Lawrence Salkoff, Karl L. Magleby 2207-P lat 11:00 am DIVALENT CATION-DEPENDENT MOTION OF THE BK CHANNEL GATING-RING REPORTED BY STATE DEPENDENT FRET. Pablo Miranda , Teresa Giraldez, Miguel Holmgren 2208-P lat 11:15 am SUBSTITUTIONS AT F380 IN S6 BY SMALL HYDROPHOBIC AMINO ACIDS MAKES THE OPENING TRANSITION IN BK CHANNELS RATE LIMITING. Willy Carrasquel-Ursulaez , Gustavo F. Contreras, Romina Sepúlveda, Daniel Aguayo, Fernando D. Gonzalez-Nilo, Carlos González, Ramón Latorre 2209-P lat 11:30 am DYNAMIC CA 2+ SENSITIVITY OF BK CHANNELS. Panpan Hou, Feng Xiao, Ming Yuchi, Guohui Zhang, Ying Wu, Wei Wang, Wenping Zeng, Mingyue Ding, Zhengxing Wu, Jianming Cui, Jiuping Ding 2210-P lat 11:45 am NMR STRUCTURAL STUDY OF THE DOMAINS OF THE KCNH CHANNELS AND ITS INSIGHT INTO CHANNEL GATING. Congbao Kang 2211-P lat 12:00 pm STRUCTURAL BASIS OF LIPID-DRIVEN CONFORMATIONAL CHANGES IN THE HYPERPOLARIZATION-ACTIVATED POTASSIUM CHANNEL MVP. Amelia M. Randich , Ernesto Vargas, Sherry S. Wanderling, Eduardo Perozo Co-Chairs Daniel Hoersch, University of California, San Francisco Dorothy Beckett, University of Maryland, College Park 2212-P lat 10:45 am SMOOTH FUNCTIONAL TRANSITION ALONG A MUTATIONAL PATHWAY WITH AN ABRUPT PROTEIN FOLD SWITCH. Christian Holzgräfe , Stefan Wallin 2213-P lat 11:00 am HYDOPHOBIC GUIDED PROTEIN FOLDING. Alberto Perez , Justin L. MacCallum, Ken A. Dill 10:45 am –12:45 pm , R oom 303 Platform Protein Design and Folding

10:45 am –12:45 pm , R oom 304 Platform DNA Structure and Dynamics

Co-Chairs Carey Phelps, University of Oregon Steve Meisburger, Cornell University 2220-P lat 10:45 am

SORTING OUT THE STRUCTURE OF SINGLE-STRANDED DNA. Steve Meisburger , Julie Sutton, Huimin Chen, Kurt Andresen,

Lois Pollack 2221-P lat

11:00 am SINGLE MOLECULE FRET STUDIES OF DNA HAIRPIN FOLDING. Katherine Truex , Hoi Sung Chung, William A. Eaton, John Louis 2222-P lat 11:15 am FRICTION AND INTERACTIONS BETWEEN BARE DNA MOLECULES: THE ROLE OF DNA HANDEDNESS. Graeme A. King , Ruggero Cortini, Dominic J. Lee, Alexei A. Kornyshev, Gijs J.L Wuite 2223-P lat 11:30 am PHYSICAL MODELING OF CHROMOSOME SEGREGATION IN E. COLI REVEALS IMPACT OF FORCE AND DNA RELAXATION. Thomas J. Lampo , Nathan J. Kuwada, Paul A. Wiggins, Andrew J. Spakowitz 2224-P lat 11:45 am MULTIPLE DYNAMIC DNA REARRANGEMENTS ARE TIGHTLY COUPLED TO DISTINCT STAGES OF HUMAN TELOMERASE CATALYSIS. Joseph Parks 2225-P lat 12:00 pm STUDIES OF T4 PRIMOSOME DNA UNWINDING BY SINGLE- MOLECULE FLUORESCENCE-DETECTED LINEAR DICHROISM. Carey Phelps

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Biophysical Society 58 th Annual Meeting, San Francisco, California