Program Book

2193-S ymp 11:40 am STRUCTURAL AND MECHANISTIC DIVERSITY OF ABC TRANSPORTERS. Douglas C. Rees 2194-S ymp 12:05 pm ROLE OF MEMBRANE LIPIDS IN ACTIVATING G-PROTEIN-COUPLED RECEPTORS. Michael F. Brown , Udeep Chawla, Suchithranga M. D. C. Perera, Andrey V. Struts 2195-S ymp 12:30 pm DECONSTRUCTING THE PHYSICAL AND MOLECULAR BASIS OF TOUCH AND PAIN SENSATION. Miriam B. Goodman 10:45 am –12:45 pm , R oom 130/131 Platform Optical Microscopy and Super Resolution Imaging II Co-Chairs WATCHING GENE REGULATION BY SMALL RNA IN BACTERIA WITH SUPER-RESOLUTION IMAGING. Jingyi Fei , Digvijay Singh, Qiucen Zhang, Seongjin Park, Ido Golding, Carin K. Vanderpool, Taekjip Ha 2197-P lat 11:00 am THE TOPOLOGICAL ORGANIZATION OF THE INACTIVE X CHROMOSOME IN ITS NATIVE STATE. Elizabeth A. Smith , Gerry McDermott, Karen Leung, Barbara Panning, Carolyn A. Larabell, Mark A. Le Gros 2198-P lat 11:15 am OBSERVATION OF THE CHANGE OF SYNAPSES AFTER LONG-TERM POTENTIATION INDUCTION USING SUPER-RESOLUTION IMAGING. Sang Hak Lee , En Cai, Okunola Jeyifous, Michelle A. Baird, Michael W. Davidson, William N. Green, Paul R. Selvin 2199-P lat 11:30 am SINGLE-MOLECULE FLUORESCENCE IMAGING REVEALS MISMATCH REPAIR DYNAMICS IN LIVE BACILLUS SUBTILIS. Yi Liao, Jeremy W. Schroeder, Lyle A. Simmons, Julie S. Biteen 2200-P lat 11:45 am SUBDIFFRACTION IMAGING REVEALS MOLECULAR ARCHITECTURE AT THE TRANSITION ZONE OF PRIMARY CILIA. T. Tony Yang, Won-Jing Wang, Arthi Suresh, Meng-Fu Bryan Tsou, Jung-Chi Liao 2201-P lat 12:00 pm SUPER-RESOLUTION IMAGING OF TELOMERES REVEALS THAT COMPACTION OF TELOMERIC DNA BY SHELTERIN PROTECTS CHROMOSOME TERMINII. Jigar N. Bandaria , Veysel Berk, Steven Chu, Ahmet Yildiz 2202-P lat 12:15 pm LIVE 4D IMAGING OF THE EMBRYONIC VERTEBRATE HEART WITH TWO-PHOTON LIGHT SHEET MICROSCOPY AND SIMULTANEOUS OPTICAL PHASE STAMPING. Thai V. Truong , Vikas Trivedi, Le Trinh, Daniel Holland, Francesco Cutrale, John M. Choi, Scott E. Fraser 2203-P lat 12:30 pm STRUCTURALLY DISTINCT CA 2+ DOMAINS OF SPERM FLAGELLA MODULATE HYPERACTIVATED MOTILITY. Sang-Hee Shim , Jean-Ju Chung, Xiaowei Zhuang, David E. Clapham Julie Biteen, University of Michigan Jung-Chi Liao, Columbia University 2196-P lat 10:45 am

9:00 am –10:00 am , R oom 124 Subgroup Chairs Meeting 9:00 am –10:30 am , R oom 123 Exhibitor Presentation Wyatt Technology Corporation

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Essential Biophysical Characterization TM : Molar Mass, Size, Charge and Interactions—The Light Scattering Toolbox for Biomolecules and Nanoparticles Wyatt Technology provides the essential tools for characterization of biomacromolecules in solution, including peptides, proteins and oligo- nucleotides, as well as bionanoparticles such as exosomes and VLP’s. This presentation describes the light scattering instrumentation and techniques used in these analyses: coupled to liquid chromatographic separations for absolute molar mass and size distributions (SEC/FFF-MALS); microtiter plate-based, high throughput screening of size, aggregation and interac- tions (DLS); and the label-free, immobilization-free analysis of biomo- lecular interactions for affinity and absolute molecular stoichiometry (CG-MALS). A variety of examples illustrate the unique capabilities of these light scattering measurements in biophysics. Presenters: Chris Broomell, Applications Scientist, Wyatt Technology Corporation Sophia Kenrick, Application Scientist, Wyatt Technology Corporation 9:30 am –10:30 am , R oom 300 Career Center Workshop The Power of Groups: How to Help Others Help You in Your Job Search It doesn’t matter how smart or talented you are, you need help from other people to ensure ongoing success. To find a job and build a successful career, you of course need to be aware of your personal strengths but you should also understand how others can help you. As Peter Drucker, a man- agement guru puts it: “The first secret of effectiveness is to understand the people you work with so that you can make use of their strengths.” This interactive workshop will help you learn how to tap into the individual and collective wisdom present in your groups. 10:00 am –5:00 pm , H all D Biomolecular Discovery Dome 10:00 am –5:00 pm , H all D Exhibits 10:15 am –11:00 am , H all D Coffee Break 10:45 am –12:45 pm , R oom 134 Symposium Awards Symposium Chair Francisco Bezanilla, University of Chicago, Society President 2192-S ymp 10:45 am PHASES AND FLUCTUATIONS IN BIOLOGICAL MEMBRANES.

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Sarah Veatch N o A bstract

11:05 am MULTISCALE SIMULATIONS OF BIOLOGICAL SYSTEMS. Arieh Warshel

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Biophysical Society 58 th Annual Meeting, San Francisco, California