Program Book

2172-P lat

9:15 am

2182-P lat 9:45 am HYPERPHOSPHORYLATION OF RYRS UNDERLIES TRIGGERED ACTIVITY INTRANSGENIC RABBITMODEL OF LQT2 SYNDROME. Dmitry Terentyev , Weyian Li, Radmila Terentyeva, Leroy L. Cooper, YiChun Lu, Hitesh Jindal, Xuwen Peng, Gideon Koren 2183-P lat 10:00 am RAPID CALCIUM MODULATION IN CELLS: DIRECT INTRACELLULAR ACCESS USING NANOSTRAWS. Alexander Xu , Sally A. Kim, Amin Aalipour, Nicholas A. Melosh

education travel awardee ARCHITECTURAL ROLE OF HMO1 IN BENDING, BRIDGING AND COMPACTING DNA. Divakaran Murugesapillai , Micah J. McCauley, Ran Huo, Molly H. Nelson Holte, L. James Maher III, Nathan E. Israeloff, Mark C. Williams 2173-P lat 9:30 am DIRECT VISUALIZATION OF DNA DYNAMICS DURING THE TELOMERASE CATALYTIC CYCLE REVEALS THE FUNCTION OF A CONSERVED TELOMERASE DOMAIN. Benjamin M. Akiyama , Michael D. Stone 2174-P lat 9:45 am TARGETING AND DEGRADATION OF VIRAL DNA BY THE CRISPR-CAS SYSTEM OF ESCHERICHIA COLI. Sy Redding , Samuel H. Sternberg, Prashant Bhat, Chantal K. Guegler, Megan L. Hochstrasser, Blake Wiedenheft, Jennifer A. Doudna, Eric C. Greene 2175-P lat 10:00 am SELECTIVE ACETYLATION REVEALS DISTINCT ROLES OF HISTONES H3 AND H4 IN NUCLEOSOME DYNAMICS - A FRET STUDY. Alexander Gansen , KatalinToth, Lars Nordenskiöld, Jörg Langowski 8:15 am –10:15 am , R oom 305 Platform Calcium Fluxes, Sparks, and Waves Co-Chairs Niall Macquaide, University of Glasgow, United Kingdom Dmitry Terentyev, Brown University and Rhode Island Hospital 2176-P lat 8:15 am DECOMPOSITION OF A CALCIUM SPARK IN CARDIAC MYOCYTES. Didier X.P. Brochet , W. Jonathan Lederer 2177-P lat 8:30 am EXAMINATION OF SINGLE CHANNEL RYR BEHAVIOR FROM LONG-LASTING CA 2+ SPARKS. Cherrie HT KONG, Mark B. Cannell 2178-P lat 8:45 am ACTIVITY OF BOTH PKA AND CAMKII IS REQUIRED FOR MAXIMAL RYR SENSITIVITY UNDER BETA-ADRENERGIC STIMULATION. Ardo Illaste, Eva Polakova , Ernst Niggli, Eric A. Sobie 2179-P lat 9:00 am CRITICAL REQUIREMENTS FORTHE INITIATIONOF A CARDIAC ARRHYTHMIA IN HEART: CELL NUMBER. Aman Ullah, Minh Tuan Hoang Trong, George S. B. Williams, Raimond L. Winslow, William J. Lederer, Mohsin S. Jafri 2180-P lat 9:15 am STRUCTURAL AND FUNCTIONAL ALTERATION OF RYR CLUSTERS AFTER REMODELING IN PERSISTENT ATRIAL FIBRILLATION. Niall Macquaide , Hoang-Trong M. Tuan, Jun-Ichi Hotta, Wouter Sempels, Ilse Lenaerts, Patricia Holemans, Johan Hofkens, Saleet Jafri, Rik Willems, Karin R. Sipido 2181-P lat 9:30 am SUBCELLULAR ORIGIN AND TISSUE-WIDE SYNCHRONIZATION OF ABNORMAL CA RELEASE IN THE GENESIS OF CA-DEPENDENT ATRIAL ARRHYTHMIA. Qing Lou , Bin Liu, Andriy E. Belevych, Przemyslaw Radwanski, Anu Kalyanasundaram, Wolfgang H. Dillmann, Antonis A. Armoundas, Bjorn C. Knollmann, Vadim V. Fedorov, Sándor Györke

8:15 am –10:15 am , R oom 306 Platform Ion Channels and Disease

Co-Chairs Heike Wulff, University of California, Davis Melissa Miller, University of California, Berkeley 2184-P lat 8:15 am

education travel awardee A ROBUST HIGH-THROUGHPUT ASSAY FORTHERMODYNAMIC CORRECTORS OF THE PREDOMINANT MOLECULAR DEFECT CAUSING CYSTIC FIBROSIS. Chi Wang , Pradeep Kota, Zhengrong Yang, Andrei Aleksandrov, Jianli An, Farhad Forouhar, Greg Boel, Nikolay Dokholyan, John Riordan, Christie Brouillette, John Hunt 2185-P lat 8:30 am CONVERTING A STIMULATORY ATP BINDING SITE TO AN INHIBITORY ONE BY THE DISEASE-ASSOCIATED MUTATION, G551D. Wen-Ying Lin , Kang-Yang Jih, Tzyh-Chang Hwang 2186-P lat 8:45 am INFLUENZA A BLOCKERS WITH REDUCED RESISTANCE FORMATION. Antonios Kolocouris, F. Brent Johnson, Roland Zell, Michaela Schmidtke, Francesc X. Sureda, Timothy A. Cross, David Fedida, Christina Tzitzoglaki, Harris Ioannidis, Anja Hoffman, Marta López-Querol, Anna K. Wright, Daniel Kwan, Kelly McGuire, David D. Busath 2187-P lat 9:00 am DUAL REGULATION OF G PROTEINS AND THE G PROTEIN-ACTIVATED POTASSIUM CHANNELS (GIRK) BY LITHIUM. Isabella Farhy Tselnicker, Vladimir Tsemakhovich, Ida Rishal, Carmen W. Dessauer, Nathan Dascal 2188-P lat 9:15 am THE MICROGLIAL K + CHANNELS KV1.3 AND KCA3.1 AS POTENTIAL THERAPEUTIC TARGETS FOR ISCHEMIC STROKE. Heike Wulff , Yi-Je Chen, Paul D. Jenkins, Hai Nguyen, April L. Garing, 9:30 am EPILEPSY-ASSOCIATED POINT MUTATION IN THE PORE DOMAIN OF KV2.1. Kevin R. Bersell , Benjamin S. Jorge, Jennifer A. Kearney, Alfred L. George, Jr. 2190-P lat 9:45 am MOLECULAR DYNAMICS STUDIES OF ION PERMEATION IN HUMAN VOLTAGE-GATED PROTON CHANNEL. Kulleperuma Kulleperuma , Deri Morgan, Borris Musset, Susan M.E. Smith, Sindhu Rajan, Vladimir V. Cherny, Thomas E. DeCoursey, Regis Pomes 2191-P lat 10:00 am REGULATION OF CATSPER CHANNEL THROUGH NON-CONVENTIONAL LIPID SIGNALING. Melissa R. Miller , Yuriy Kirichok, Polina Lishko Ralf Köhler 2189-P lat

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Biophysical Society 58 th Annual Meeting, San Francisco, California