Program Book

2:30 pm –3:30 pm , R oom 300 Career Center Workshop

4:00 pm –6:00 pm , R oom 135 Symposium Molecular Self-Assembly—from in Vitro to Cellular Systems Co-Chairs Roy Bar-Ziv, Weizmann Institute of Science, Israel Suzanne Gaudet, Harvard Medical School 2248-S ymp 4:00 pm SYMMETRY-BASED DESIGN AND STRUCTURE OF SELF- ASSEMBLING PROTEIN CAGES AND NANOMATERIALS. Yen-Ting Lai, Neil P. King, William Sheffler, Dan E. McNamara, Jacob B. Bale, David Baker, Todd O. Yeates 2249-S ymp 4:30 pm SEQUESTERED: MOLECULAR PHYSIOLOGY OF BACTERIAL MICROCOMPARTMENTS. David Savage 2250-S ymp 5:00 pm LEVERAGING CELL-TO-CELL VARIABILITY TO UNDERSTAND SIGNAL TRANSDUCTION NETWORKS. Suzanne Gaudet , Robin EC Lee 2251-S ymp 5:30 pm TOWARDS ARTIFICIAL CELLS IN 2D. Roy Bar-Ziv 4:00 pm –6:00 pm , R oom 130/131 Symposium Applications of Quantum Mechanics to Biophysical Problems Co-Chairs Qiang Cui, University of Wisconsin–Madison Sharon Hammes-Schiffer, University of Illinois at Urbana-Champaign 2252-S ymp 4:00 pm QM/MMMETHODS: RECENT DEVELOPMENTS AND APPLICATIONTOMEMBRANE PROTEINS ANDMOLECULAR MOTORS. Qiang Cui 2253-S ymp 4:30 pm HYDROGEN TUNNELING, ELECTROSTATICS, AND CONFORMATIONAL MOTIONS IN ENZYME CATALYSIS. Sharon Hammes-Schiffer 2254-S ymp 5:00 pm USING QUANTUM MECHANICS IN BIOLOGICAL STRUCTURE REFINEMENT. Kenneth M. Merz 2255-S ymp 5:30 pm CLASSICAL AND MIXED QUANTUM MECHANICAL/ MOLECULAR MECHANICAL (QM/MM) SIMULATIONS OF G PROTEIN COUPLED RECEPTORS. Ursula Rothlisberger

What to Do When You Are Tired of Doing What You Are Doing: A Unique Interactive Workshop for Experienced Workers Do you ever have “one of those days?” You know, the ones where you look around you and wonder how long you can keep on doing what you’ve always been doing? And how could you possibly have been doing this for so long? And what else is out there for you? This facilitated discussion will explore these and similar questions from the audience and then involve the audience in providing career tips and techniques for experienced profes- sionals. Please come prepared to share experiences and give/get advice. We anticipate a lively discussion about choices and their consequences. 2:30 pm –4:30 pm , R oom 309 PhD Careers Beyond the Bench Have you ever wondered how you can apply the skills learned during your PhD in a career away from the bench? The Early Careers Committee is sponsoring a panel to discuss the plethora of career options that exist beyond the bench, such as publishing, science writing, patent law, policy, marketing etc. Panelists involved in a wide variety of careers will share their personal experiences. Speakers: Prithwish Pal, Invivoscribe Technologies Peter Aldhous, University of California, Santa Cruz Science Communication Program Walter Ausserer, ForteBio, A Division of Pall Life Sciences 3:00 pm –5:00 pm , R oom 122 Education Committee Meeting 4:00 pm –6:00 pm , R oom 134 Symposium Structural Dynamics of Molecular Machines Co-Chairs Julio Fernandez, Columbia University Yasmine Meroz, Harvard University 2244-S ymp 4:00 pm POSTTRANSLATIONAL MODIFICATIONS AS MODULATORS OF MECHANICAL PROTEIN FOLDING. Julio Fernandez 2245-S ymp 4:30 pm A ZOO OF SLOW DYNAMICS. Yasmine Meroz 2246-S ymp 5:00 pm DIRECT MEASUREMENTS OF TRANSCRIPTION FACTOR BINDING AND DISSOCIATION AT INDIVIDUAL CHROMOSOMAL OPERATORS. Johan Elf 2247-S ymp 5:30 pm CLPX, A STOCHASTIC PROTEIN UNFOLDING AND TRANSLOCATION MACHINE. Robert T. Sauer , Ohad Yosefson, Benjamin M. Stinson, Andrew R. Nager, Steven E. Glynn, Karl R. Schmitz, Adrian O. Olivares, Harris W. Manning, Yongdae Shin, Juan C. Cordova, Matthew J. Lang, Tania A. Baker 3:00 pm –4:30 pm , R oom 123 Exhibitor Presentation GE Healthcare The Devil is in the Detail: the Importance of Accurate Stability and Concentration Determination in Biomolecular Interaction Analysis

T U

E S

D A Y

4:00 pm –6:00 pm , R oom 132/133 Platform Excitation-Contraction Coupling

Co-Chairs Susan Treves, Basel University Hospital, Switzerland Ole Kemi, University of Glasgow, United Kingdom 2256-P lat 4:00 pm

BIOCHEMICAL, CELLULAR AND ELECTROPHYSIOLOGICAL CHARACTERIZATION OF HMCL-7304 A HUMAN SKELETAL MUSCLE-DERIVED CELL LINE. Ori Rokach, Nina D. Ullrich, Martin Rausch, Haiyan Zhou, Francesco Muntoni, Francesco Zorzato, Susan Treves

125

Biophysical Society 58 th Annual Meeting, San Francisco, California