Program Book

2257-P lat 4:15 pm STRUCTURAL AND BINDING STUDIES OF THE CAV1.1 β 1A SUBUNIT. Marco G. Casarotto , Yamuna Karunasekara, Shouvik Aditya, Jean Cappello, Angela F. Dulhunty, Philip G. Board, Aaron J. Oakley, Nicole C. Norris 2258-P lat 4:30 pm DISSECTING ROLES OF CAV1.2 ( α 1C) INTRACELLULAR LOOPS IN CARDIAC EXCITATION-CONTRACTION COUPLING. Prakash Subramanyam , Donald D. Chang, Henry M. Colecraft 2259-P lat 4:45 pm PIP2 MODULATES T-TUBULE REMODELING DURING HEART FAILURE BY WORKING AS A BINDING SUBSTRATE FOR BIN1. Neha Singh , Suresh K. Verma, William Marszalec, Gary L. Aistrup, Raj Kishore, J Andrew Wasserstrom 2260-P lat 5:00 pm SPATIO-TEMPORAL RELATIONSHIP BETWEEN T-TUBULAR ELECTRICAL ACTIVITY AND CA 2+ RELEASE IN HEART FAILURE. Claudia Crocini , Raffaele Coppini, Cecilia Ferrantini, Ping Yan, Leslie M. Loew, Chiara Tesi, Elisabetta Cerbai, Corrado Poggesi, Francesco S. Pavone, Leonardo Sacconi 2261-P lat 5:15 pm NON-LINEAR RELATIONSHIP BETWEENT-TUBULE REMODELING AND SR CALCIUM RELEASE IN FAILING RAT VENTRICLE. Jasleen Singh, Nikhil Bassi, Shannon Tai, Shruthi Mothkur, William Marszalec, Neha Singh, Gary L. Aistrup, J. AndrewWasserstrom 2262-P lat 5:30 pm CARDIOMYOCYTE CALCIUM HANDLING DYSFUNCTION AT HIGH STIMULATION FREQUENCIES; INCREASE IN POST- MYOCARDIAL INFARCTION HEART FAILURE AND DECREASE BY EXERCISETRAINING. Ole J. Kemi , Alex S. Johnston, Godfrey L. Smith 2263-P lat 5:45 pm NANOSCALE CHANGES INTHEORGANISATIONOF JUNCTIONAL PROTEINS IN JPH2 TRANSGENIC MICE. Michelle Munro, Wei Wang, David Baddeley, Xander Wehrens, Christian Soeller Co-Chairs Hartmut Luecke, University of California, Irvine Andrew Battle, Griffith University, Australia 2264-P lat 4:00 pm A DIMERIC DUAL-TOPOLOGY MICROBIAL FLUORIDE CHANNEL. Randy Stockbridge , Janice L. Robertson, Ludmila Kolmakova-Partensky, Christopher Miller 2265-P lat 4:15 pm A REPULSION MECHANISM EXPLAINS MAGNESIUM PERMEATION AND SELECTIVITY IN CORA. Olivier Dalmas , Walter Sandtner, David Medovoy, Ludivine Frezza, Francisco Bezanilla, Eduardo Perozo 2266-P lat 4:30 pm MECHANISMS OF MOLECULAR TRANSPORT THROUGH THE PROTON-GATED UREA CHANNEL OF HELICOBACTER PYLORI. Hartmut Luecke , Reginald McNulty, Martin Ulmschneider, Jacob Ulmschneider 4:00 pm –6:00 pm , R oom 303 Platform Other Channels

2267-P lat 4:45 pm MODULATION OF THE BACTERIAL MECHANOSENSITIVE CHANNEL OF SMALL CONDUCTANCE (MSCS) BY CARDIOLIPIN - ELECTROPHYSIOLOGICAL, ALANINE MUTAGENESIS AND MODELLING STUDIES. Pietro Ridone, Samantha Maguire, Boris Martinac, Andrew R. Battle 2268-P lat 5:00 pm NOVEL MUTATIONS IN THE EXTRACELLULAR CAP OF THE MAMMALIAN MECHANOSENSITIVE CHANNEL TREK-1. Paul Blount, Robin Wray, Irene R. Iscla 2269-P lat 5:15 pm OMEGA 6 POLYUNSATURATED FATTY ACID-CONTAINING PHOSPHOLIPIDS ENHANCE NEURONAL CELL MECHANICS AND TOUCH IN C. ELEGANS. Valeria Vasquez , Michael Krieg, Dean Lockhead, Miriam B. Goodman 2270-P lat 5:30 pm TOUCH ACTIVATES MECHANOSENSITIVE ION CHANNELS IN MERKEL CELLS IN VITRO. Masashi Nakatani , Aislyn M. Nelson, Ellen A. Lumpkin 2271-P lat 5:45 pm MOLECULAR MECHANISMS OF DEAFNESS MUTATIONS DISRUPTING TIP-LINK FUNCTION IN HAIR-CELL MECHANOTRANSDUCTION. Marcos Sotomayor , Rachelle Gaudet, David P. Corey Co-Chairs Kurt Andresen, Gettysburg College Dario Anselmetti, Bielefeld University, Germany 2272-P lat 4:00 pm DISULFIDE BONDS ARE ALLOSTERIC REGULATOR OF MECHANICAL STABILITY. David Giganti , Guillaume Stirnemann, Kevin Yan, Bruce Berne, Julio Fernandez 2273-P lat 4:15 pm QUANTIFYING THE RESOLUTION OF SINGLE-MOLECULE TORQUE MEASUREMENTS BY ALLAN VARIANCE. Jan Lipfert , Maarten van Oene, Tessa Jager, Mina Lee, Francesco Pedaci, Nynke H. Dekker 2274-P lat 4:30 pm COMBINED SINGLE MOLECULE FORCE AND FLUORESCENCE SPECTROSCOPY OF THE UNFOLDING AND REFOLDING OF GREEN FLUORESCENT PROTEIN. Ziad Ganim , Matthias Reisser, Matthias Rief 2275-P lat 4:45 pm VWF - COLLAGEN INTERACTIONS STUDIED WITH SINGLE MOLECULE FORCE SPECTROSCOPY. Sandra Posch , Tobias Obser, Maria A. Brehm, Hermann J. Gruber, Reinhard Schneppenheim, Robert Tampé, Peter Hinterdorfer 2276-P lat 5:00 pm RESOLVINGTHE MOLECULAR DETERMINANTS OF CADHERIN CATCH BOND FORMATION. Kristine Manibog , Hui Li, Sabyasachi Rakshit, Sanjeevi Sivasankar 2277-P lat 5:15 pm CATCH BOND INTERACTION BETWEEN GLYCOSAMINOGLYCANSAND CELL SURFACE SULFATASE SULF1. Alexander Harder, Ann-Kristin Moeller, Fabian Milz, Phillipp Neuhaus, Volker Walhorn, Thomas Dierks, Dario Anselmetti 4:00 pm –6:00 pm , R oom 304 Platform Force Spectroscopy

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Biophysical Society 58 th Annual Meeting, San Francisco, California