Program Book

91-P lat 10:00 am KINETIC EXCLUSION ANALYSIS (KINEXA) OF AVIDITY ENHANCEMENT OF A MULTI-VALENT ADNECTIN BINDING TO CLUSTERED RECEPTORS ON CHO CELLS. Lumelle A. Schneeweis , Sandra V. Hatcher, Bryan Barnhart, Thomas R. Glass, Lin Cheng, Benjamin Blum, Eric Lawrence, Rolf Ryseck, Ray Camphausen, Bozena M. Abramczyk, Anthony Della Pietra, Martin J. Corbett, Thomas McDonagh, Michael L. Doyle, James Bryson

81-S ymp 8:45 am MYOSIN II CONTROLS CELLULAR BRANCHING MORPHOGENESIS AND MIGRATION IN 3D BY MINIMIZING PLASMA MEMBRANE CURVATURE. Fischer A. R, Hunter Elliot, Clare Waterman , Gaudenz Danuser 82-S ymp 9:15 am CONTRACTILITY DRIVEN SELF-ORGANIZATION OF THE ACTIN CYTOSKELETON. Alexander D. Bershadsky 83-S ymp 9:45 am DYNAMIC ORGANIZATION OF DEVELOPING EPITHELIA. Frank Julicher 8:15 am –10:15 am , R oom 130/131 Platform Membrane Protein Structure, Dynamics, and Interactions Co-Chairs Lumelle A. Schneeweis, Bristol-Myers Squibb Philip Biggin, Oxford University, United Kingdom 84-P lat 8:15 am INTEGRATING THE SIGNALS: IMPLICATIONS OF CFTR NBD1 ALLOSTERY TO CYSTIC FIBROSIS. Dawson E. Jennifer , Andrew Chong, Robert Vernon, Rhea Hudson, Patrick Farber, Julie D. Forman-Kay 85-P lat 8:30 am PROBING LIGAND DYNAMICS IN MEMBRANE-BOUND CYTOCHROME P450 3A4 TO CHARACTERIZE SUBSTRATE ACCESS AND PRODUCT EGRESS PATHWAYS. Javier Baylon , Emad Tajkhorshid 86-P lat 8:45 am CHARACTERIZATION OF CHOLESTEROL AND DRUG LIGAND INTERACTIONS WITH TRANSLOCATOR PROTEIN 18 KDA (TSPO) FROM RHODOBACTER SPHAEROIDES . Fei Li , Lance Valls, Shelagh Ferguson-Miller 87-P lat 9:00 am MONITORING INTRAMEMBRANE PROTEOLYTIC CLEAVAGE REACTIONS USING ISOTOPE-ASSISTED VIBRATIONAL INTERROGATIONOF MEMBRANE EMBEDDED (IVIBE) PROTEINS. Mia Brown , Renee D. JiJi, Iban Ubarretxena-Bilandia, Jason W. Cooley 88-P lat 9:15 am INVESTIGATING LIGAND-MODULATION OF GPCR ACTIVATION PATHWAYS. Morgan Lawrenz , Kai Kohlhoff, Diwakar Shukla, Greg Bowman, Russ Altman, Vijay Pande 89-P lat 9:30 am education travel awardee CRYSTAL STRUCTURE OF MRAY, AN ESSENTIAL MEMBRANE ENZYME FOR BACTERIAL CELL WALL SYNTHESIS. Ben C. Chung , JInshi Zhao, Robert Gillespie, Do Yeon Kwon, Ziqiang Guan, Jiyong Hong, Pei Zhou, Seok-Yong Lee 90-P lat 9:45 am COMBINING MODELLING AND SITE-DIRECTED MUTAGENESIS TO EXPLORE AGONIST BINDING TO HUMAN OREXIN RECEPTORS. Alexander Heifetz, Oliver Barker, G. Benjamin Morris, Richard J. Law, Mark Slack, Philip C. Biggin

8:15 am –10:15 am , R oom 132/133 Platform Voltage-gated K Channels: Activation/Inactivation Mechanisms

Co-Chairs Manuel Covarrubias, Jefferson Medical College of Thomas Jefferson University Serdar Durdagi, Bahcesehir University, Turkey 92-P lat 8:15 am A-TYPE KV4 CHANNEL CLOSED-STATE INACTIVATION IS MODULATED BY THE TETRAMERIZATION DOMAIN INTERACTING WITH AUXILARY KCHIP4A. Yi-Quan Tang, Fan Yang, Jingheng Zhou, Jie Zheng, KeWei Wang 93-P lat 8:30 am TWO-IN-ONE: ACTIVATION AND INACTIVATION AT THE INTRACELLULAR GATE OF A KV CHANNEL. Manuel Covarrubias , Jeffrey D. Fineberg 94-P lat 8:45 am DEVELOPMENT AND VALIDATION STUDIES OF UNIVERSAL PHARMACOPHORE MODELS FOR HERG CHANNEL OPENERS. Serdar Durdagi , Matthew Patterson, Sergei Y. Noskov 95-P lat 9:00 am N-TERMINAL REGULATION OF HERG1 K + CHANNEL DEACTIVATION. Steven J. Thomson , Angela Hansen, Michael C. Sanguinetti 96-P lat 9:15 am LIPID AFFINITY TO THE VOLTAGE-GATED POTASSIUM CHANNEL KVAP. Elise Faure , Christine Thompson, Rikard Blunck 97-P lat 9:30 am A STRUCTURAL DRIVEN KINETIC CYCLE FOR KCSA GATING. Luis G. Cuello , D. Marien Cortes, Eduardo Perozo 98-P lat 9:45 am STATE-DEPENDENT CROSSLINKING IN IKS DEMONSTRATES A CLOSED-STATE INTERACTION BETWEEN KCNE1 AT F57 AND KCNQ1 THAT INHIBITS CHANNEL OPENING. Christopher I. Murray , Yasmeen Maurice, Jodene Eldstrom, David Fedida 99-P lat 10:00 am MOVING GATING CHARGES THROUGH THE GATING PORE IN A KV CHANNEL VOLTAGE-SENSOR. Jerome J. Lacroix , Clark H. Hyde, Fabiana V. Campos, Francisco Bezanilla

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Biophysical Society 58 th Annual Meeting, San Francisco, California