Program Book

2770-P os B oard #B462 TOWARDS UNDERSTANDINGTHE INTERACTION OF AGONISTS WITH THE HUMAN ALPHA1 GLYCINE RECEPTOR. Rilei Yu 2771-P os B oard #B463 TOWARDS STRUCTURAL AND FUNCTIONAL DETERMI- NATION OF A NON-DESENSITIZING α 1 GLYCINE RECEP- TOR. Rathna J. Veeramachaneni , Chelsee Donelan, Michael Cascio 2772-P os B oard #B464 METHODS FOR IDENTIFICATION OF STATE-DEPENDENT CROSSLINKS FOR STRUCTURAL DETERMINATION OF MEM- BRANE PROTEINS. Chelsee A. Donelan , Rathna Veeramachaneni, Andrew Davic, Michael Cascio  Ion Channels and Disease I (Boards #B465–#B493) 2773-P os B oard #B465 LEARNING THE KINETICS OF AMYLOID β PORE IN ALZHEIMER’S DISEASE PATHOLOGY. Ghanim Ullah , Angelo Demuro, Ian Parker, John E. Pearson 2774-P os B oard #B466 INVESTIGATING HOW A β AND α SYNUCLEIN OLIGOMERS INITIALLY DEMAGE NEURONAL CELLS. Anna Drews 2775-P os B oard #B467 ACUTE EFFECTS OF β -AMYLOID (1-42) OLIGOMERS ON RAT PYRAMIDAL ENTORHINAL NEURONS. Miguel Cuaxospa, Rosana Fiorentino, Ubaldo Garcia 2776-P os B oard #B468 DISREGULATION OF CALCIUM HOMEOSTASIS CONNECTED WITH FAMILIAL ALZHEIMER’S DISEASE. Maria Ryazantseva , Ksenia Skobeleva, Elena Kaznacheyeva 2777-P os B oard #B469 TAU PROTEIN FORMS ION CHANNELS. Rustam Azimov, Bruce L. Kagan 2778-P os B oard #B470 education travel awardee ALTERATIONS IN IONIC CURRENTS AND GAP JUNCTIONAL COUPLING BY PAN-HISTONE DEACETYLASE INHIBITION. Dakshesh Patel 2779-P os B oard #B471 SELF-ASSEMBLY OF THE VIRAL CHANNEL FORMING PROTEIN VPU OF HIV-1 USING COARSE-GRAINING MOLECULAR DYNAMICS SIMULATIONS. Meng-Han Lin , Wolfgang B. Fischer 2780-P os B oard #B472 ION-TRAPPING IN HCV P7 HEXAMERIC BUNDLES - A MOLECULAR DYNAMICS SIMULATION STUDY. Wolfgang B. Fischer , Yi-Ting Wang 2781-P os B oard #B473 STRUCTURE AND INHIBITION OF THE M2 PROTON CHANNEL FROM THE INFLUENZA A VIRUS. Jun Wang , Yibing Wu, William F. DeGrado 2782-P os B oard #B474 MECHANO-SENSITIVE ION CHANNELS (MSCS) PROVIDE HUMAN BREAST CANCER CELLS WITH A SENSORIUM FOR MECHANICAL STRESS. Chouyang Li , Simin Rezania, Sarah Kammerer, Astrid Gorischek, Thomas Bauernhofer, Wolfgang Schreibmayer

2757-P os B oard #B449 EXTRACELLULAR CONTRIBUTIONS TO ALCOHOL MODULATION OF PENTAMERIC LIGAND-GATED ION CHANNELS. Amber Plante 2758-P os B oard #B450 ACTIVATION MECHANISM OF ELIC BY PROPYLAMINE. Alessandro Marabelli, Remigijus Lape, Lucia Sivilotti 2759-P os B oard #B451 PROKARYOTIC CYS-LOOP RECEPTOR HOMOLOGS AS MECHANISTIC MODELS FOR CHANNEL FUNCTION. Matthew Rienzo , Oliver S. Shafaat, Harry B. Gray, Sarah C. R. Lummis, Dennis A. Dougherty 2760-P os B oard #B452 BIOCHEMICAL AND FUNCTIONAL CHARACTERIZATION OF A NOVEL PROKARYOTE LIGAND-GATED ION CHANNEL CLIC. Mieke Nys , Radovan Spurny, Zander Claes, Chris Ulens 2761-P os B oard #B453 UTILIZING NON-EQUILIBRIUM METHODS TO PROBE THE EFFECTS OF GENERAL ANESTHETICS ON LIGAND-GATED ION CHANNEL DYNAMICS. Mark J. Arcario , Emad Tajkhorshid 2762-P os B oard #B454 LOOSE PACKING OF THE EXTRACELLULAR DOMAIN CORE OF PENTAMERIC LIGAND-GATED ION CHANNELS IS IMPORTANT FOR FAST ACTIVATION AND DESENSITIZATION. Cosma D. Dellisanti , Cynthia Czajkowski 2763-P os B oard #B455 CONSTRUCTION AND CHARACTERIZATION OF A FUNCTIONAL GLIC-GABA ρ LIGAND-GATED ION CHANNEL CHIMERA. Borna Ghosh , Varun Tiwari, Cynthia Czajkowski 2764-P os B oard #B456 ALLOSTERIC MODULATION OF GABA-A RECEPTORS BY DIFFERENT DRUGS. Borna Ghosh , Tzu-Wei Tsao, Cynthia Czajkowski 2765-P os B oard #B457 MECHANISM OF INHIBITION OF RECOMBINANT GABAA RECEPTORS BY PENTYLENETETRAZOLE AND ITS ALLEVIATION BY ANTICONVULSANTS. Akimasa Iijima, Yongli Chen 2766-P os B oard #B458 γ -AMINOBUTYRIC ACID INDUCED CONFORMATIONAL CHANGE IN GABAAR MEASURED BY PULSED ELECTRON PARAMAGNETIC RESONANCE. Yinghui Zhang, Youssef Jounaidi, Jessica L. Sarver, Xiaojuan Zhou, David S. Cafiso, Keith W. Miller 2767-P os B oard #B459 MOLECULAR CLONING OF A GABA RECEPTOR SUBUNIT FROM CRAYFISH AND VOLTAGE-CLAMP ANALYSIS OF HOMO- OLIGOMERIC RECEPTOR EXPRESSED IN HEK CELLS. Eric N. Jiménez-Vázquez , Juan M. Arias, Ubaldo García 2768-P os B oard #B460 CONTRIBUTION OF STRUCTURAL ELEMENTS TO ACTIVATION AND ALLOSTERIC MODULATION IN AN ANIONIC LIGAND-GATED ION CHANNEL. Ozge Yoluk , Erika A. Riederer, Magnus Andersson, Goran Klement, James R. Trudell, Edward J. Bertac- cini, Rebecca J. Howard, Erik Lindahl 2769-P os B oard #B461 INTERACTION OF THE GLYCINE RECEPTOR ALPHA 1 BINDING SITE WITH PARTIAL AGONISTS. Timo Greiner , Elliot Hurdiss, Rilei Yu, Remigijus Lape, Philip C. Biggin, Lucia G. Sivilotti

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Biophysical Society 58 th Annual Meeting, San Francisco, California