Program Book

2783-P os B oard #B475 DIMINAZENE INTERACTION WITH ASIC1A CHANNELS. Bogdan P. Amuzescu , Thomas Knott, Olaf Scheel, Dan Mihailescu, Maria Mernea 2784-P os B oard #B476 EFFECTS OF DISEASE-ASSOCIATED MUTATIONS ON THE CONFORMATIONS OF GABA(A) RECEPTORS. Sruthi Murlidaran , Reza Salari, Grace Brannigan 2785-P os B oard #B477 PROTEIN KINASE C-THETA CONTROLS THE CLC-1 CHLORIDE CHANNEL FUNCTION AND SKELETAL MUSCLE PHENOTYPE: A BIOPHYSICAL AND GENE EXPRESSION STUDY IN PKC-THETA NULL MICE. Giulia M. Camerino , Michela De Bellis, Maria Cannone, Antonella Liantonio, Kejla Musaraj, Jean-Francois Desaphy, Luca Madaro, Marina Bouchè, Sabata Pierno 2786-P os B oard #B478 BLOCKING KCA1.1 CHANNELS INHIBITS THE PATHOGENIC FEATURES OF FIBROBLAST-LIKE SYNOVIOCYTES AND TREATS RAT MODELS OF RHEUMATOID ARTHRITIS. Mark R. Tanner, Xueyou Hu, Redwan Huq, Teresina Laragione, Rajeev B. Tajhya, Frank T. Horrigan, Percio S. Gulko, Christine Beeton 2787-P os B oard #B479 THE FUNCTIONAL SWTICH IN POTASSIUM CHANNELS IN MYOTONIC DYSTROPHY TYPE 1 IMPAIRS PROLIFERATION, MIGRATION AND FUSION DURING MYOGENESIS. Rajeev B. Tajhya , Xueyou Hu, Mark R. Tanner, Lubov Timchenko, Christine Beeton 2788-P os B oard #B480 ALTERED GATING OF KV1.3 CHANNELS OF T LYMPHOCYTES IN SMITH-LEMLI-OPITZ SYNDROME. Andras Balajthy , Sandor Somodi, Maria Peter, Zoltan Petho, Laszlo Vigh, Gyorgy Panyi, Peter Hajdu 2789-P os B oard #B481 LOCALIZATION OF THE PLASMODIUM FALCIPARUM K + CHANNEL, PFKCH1. Matias Martin , Mark Luciani, Anders Hay-Schmidt, Peter Ellekvist, Dan A. Klaerke 2790-P os B oard #B482 MALIGNANT LYMPHOBLASTS IN T CELL ACUTE LYMPHOBLASTIC LEUKEMIA EXPRESS HIGH LEVELS OF KV1.3. Eva Groessinger , Lukas Weiss, Mingyi Chen, Heike Wulff, Richard Greil, Hubert Kerschbaum 2791-P os B oard #B483 MARGATOXIN IS A NONSELECTIVE INHIBITOR OF KV1.3 CHANNELS - A COMPREHENSIVE STUDY. Adam Bartok , Agnes Toth, Peter Hajdu, Zoltan Varga, Gyorgy Panyi 2792-P os B oard #B484 MECHANISMS OF ATP-SENSITIVE POTASSIUM CHANNEL OVERACTIVITY IN CANTU MUTANTS. Paige Cooper , Monica Sala-Rabanal, Colin Nichols 2793-P os B oard #B485 TWO-PORE-DOMAIN TASK-1 POTASSIUM CHANNELS MODULATE PANCREATIC ISLET GLUCAGON SECRETION. Prasanna Dadi, Brooke Luo, David Jacobson 2794-P os B oard #B486 CLONING OF EQUINE KCNH2 AND KCNQ1 AS THE BASIS FOR DIAGNOSING LONG QT SYNDROME IN HORSES. Philip J. Pedersen , Jon B. Flak, Rikke Buhl, Dan A. Klaerke

2795-P os B oard #B487 cpow travel awardee ISOGENIC SETS OF HUMAN PLURIPOTENT STEM CELLS AS MODEL OF LQT2 SYNDROME. Simona Casini , Milena Bellin, Richard P. Davis, Cristina D’ Aniello, Jessica Haas, Dorien Ward-van Oostwaard, Leon G. J. Tertoolen, Karl-Ludwig Laugwitz, Alessandra Moretti, Christine L. Mummery 2796-P os B oard #B488 DYNAMIC ACTION POTENTIAL CLAMP INVESTIGATION OF PRO-ARRHYTHMIC RISK OF DRUGS BINDING TO HERG POTASSIUM CHANNELS. Stefan A. Mann , Jamie I. Vandenberg 2797-P os B oard #B489 CA 2+ SENSITIVITY OF L-TYPE CALCIUM CHANNEL INACTIVATION PROBED BY CA 2+ PHOTOUNCAGING—WIN- DOW ONTO CALMODULINOPATHIES. Worawan Limpitikul , David T. Yue 2798-P os B oard #B490 TRAFFICKING-DEFECTIVE KIR6.1 (KATP) MUTATIONS IN SUDDEN INFANT DEATH SYNDROME. Bi-Hua Tan , Rou-Mu Hu, Blaise Peterson, Sinisa Dovat, Michael J. Ackerman, Jonathan C. Makielski, Chunhua Song 2799-P os B oard #B491 HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTES (HIPS-CM’S): AN EXPRESSION MODEL SYSTEM FOR INVESTIGATING CARDIAC CHANNELOPATHIES. Ravi Vaidyanathan , John Kyle, Deborah L. Capes, Timothy J. Kamp, Craig T. January, Lee L. Eckhardt, Jonathan C. Makielski 2800-P os B oard #B492 INTERLEUKIN 1 Β MODULATES THE VENTRICULAR L-TYPE CALCIUM CURRENT THROUGH ROS SIGNALLING. Nabil El Khoury , Sophie Mathieu, Céline Fiset 2801-P os B oard #B493 A NOVEL NA V 1.1 MUTATION L1613P ASSOCIATED WITH FAMILIAL HEMIPLEGIC MIGRAINE. Chunxiang Fan , Frank Lehmann-Horn, Karin Jurkat-Rott  Other Channels (Boards #B494–#B526) 2802-P os B oard #B494 cpow travel awardee A LACK OF SIGNIFICANT LIPID INTERACTIONS IN THE OPEN STATE OF MSCS IMPLIES A JACK-IN-THE-BOX TYPE CHANNEL GATING MECHANISM. Hannah R. Malcolm , Paul Blount, Joshua A. Maurer 2803-P os B oard #B495 FOLLOWING THE GLOBAL STRUCTURAL CHANGES OF AN ION CHANNEL DURING ITS GATING BY USING A NOVEL MASS SPECTROMETRY APPROACH. Duygu Yilmaz , Albert Konijnenberg, Helgi Ingólfsson, Anna Dimitrova, Siewert J. Marrink, Frank Sobott, Armağan Koçer 2804-P os B oard #B496 THE RATE OF OSMOTIC SHOCK DETERMINES BACTERIAL SURVIVAL. Heun Jin Lee , Maja Bialecka-Fornal, Rob Phillips 2805-P os B oard #B497 GATING MECHANISM OF MECHANOSENSITIVE ION CHANNELS STUDIED BY CONTINUUM MECHANICS. Navid Bavi, Takeshi Nomura, Qinghua Qin, Boris Martinac

T U

E S

D A Y

149

Biophysical Society 58 th Annual Meeting, San Francisco, California