Program Book

8:15 am –10:15 am , R oom 132/133 Platform Neurons: Modeling, Synaptic Transmission, and Optogenetics Co-Chairs Guido Zampighi, University of California, Los Angeles, School of Medicine Neda Najafinobar, Chalmers University of Technology, Sweden 3177-P lat 8:15 am USING A CELL MODEL TO STUDY THE EFFECT OF CHOLESTEROL ON EXOCYTOSIS. Neda Najafinobar , Lisa Mellander, Mike E.Kurczy, Ann Sofie Cans 3178-P lat 8:30 am BDNF MODULATES PRESYNAPTIC FUNCTIONS AT A CENTRAL SYNAPSE. Maryna Baydyuk , Xinsheng Wu, Jiansong Sheng, Liming He, Ling-Gang Wu 3179-P lat 8:45 am SYNAPSES BETWEEN INTERNEURONS IN THE RAT CEREBRAL CORTEX AT 2NM RESOLUTION AND IN THREE-DIMENSIONS. Guido A. Zampighi , Julio Vergara 3180-P lat 9:00 am SYP1 ACTS AS A CLEARANCE FACTOR FOR SYB2 AT THE PRESYNAPSE. Anne Gauthier-Kemper , Rajit Rajappa, Martin Wiemhöfer, Cora S. Thiel, Jana Hüve, Jürgen Klingauf 3181-P lat 9:15 am SINGLE MOLECULE MOTION MAPS OF OPEN AND DESENSITIZATION STATES OF NICOTINIC ACETYLCHOLINE RECEPTORS. Hiroshi Sekiguchi , Maki Tokue, Yuri Nishino, Kouhei Ichiyanagi, Naoto Yagi, Atsuo Miyazawa, Tai Kubo, Yuji C. Sasaki 3182-P lat 9:30 am PHOTOSWITCHING HCN CHANNELS IN DEGENERATED RETINA NEURONS. Vadim E. Degtyar , Ivan Tochitsky, Caleb Smith, Richard H. Kramer 3183-P lat 9:45 am education travel awardee DEVELOPMENT OF A RED GENETICALLY-ENCODED VOLTAGE INDICATOR AND ITS USEWITH CHANNELRHODOPSIN FOR ALL-OPTICAL ELECTROPHYSIOLOGY. Ahmed S. Abdelfattah , Jelena Platisa, Yongxin Zhao, Vincent A. Pieribone, Robert E. Campbell 3184-P lat 10:00 am OPTOGENETIC STIMULATION OF CHANNELRHODOPSIN-2 EXPRESSING NEURONS FLIPS CORTICAL NETWORKS FROM LOW TO HIGH ACTIVITY STATE. Parijat Sengupta , Lindsay Fague

3186-P lat 8:30 am ELECTRICAL PROPAGATION OF THREE-DIMENSIONAL ENGINEERED HEARTS USING DECELLULARIZED EXTRACELLULAR MATRIX. Haruyo Yasui , Jong-Kook Lee, Akira Yoshida, Teruki Yokoyama, Junichi Nakai, Issei Komuro 3187-P lat 8:45 am SPATIOTEMPORAL TRANSITIONS IN CARDIAC NEURONAL CO-CULTURES. Rebecca AB Burton, Guy Stephens, Amy Sharkey, Sam Bilton, Hege Larsen, Holger Kramer, Carla Schmidt, Claudia Molina, Dan Li, Gary Mirams, Carol Robinson, David Paterson, Gil Bub 3188-P lat 9:00 am VOLTAGE AND CALCIUM COUPLING IN THE GENESIS OF CARDIAC AFTERDEPOLARIZATIONS. Zhen Song , Alain Karma, Hrayr S. Karagueuzian, James N. Weiss, Zhilin Qu 3189-P lat 9:15 am education travel awardee CORRELATION BETWEEN VENTRICULAR REPOLARISATION PATTERNS AND T-WAVE GENERATION IN ISOLATED RABBIT HEARTS USING PANORAMIC IMAGING. Andrew Allan , Godfrey Smith, Francis Burton 3190-P lat 9:30 am ENHANCED DIFFERENTIATION OF STEMCELL DERIVED CARDIACMYOCYTES BY ELECTRONIC EXPRESSION OF IK1 REVEALS AN ATRIAL-SPECIFIC KV1.5-LIKE CURRENT. Aaron D. Kaplan, Agnieszka Lis, Thomas R. Cimato, Emmanuel S. Tzanakakis, Qinlian Zhou, Michael J. Morales, Randall L. Rasmusson, Glenna C L Bett 3191-P lat 9:45 am PLB DRIVES THE KINETICS OF THE CA 2+ CLOCK IN MOUSE ISOLATED SINOATRIAL NODAL CELLS AND THE INTRINSIC HEART RATE INVIVO. Syevda Sirenko , Ismayil Ahmet, Edward G. Lakatta 3192-P lat 10:00 am BURST PACEMAKER ACTIVITY IN NCX1 KNOCKOUT MICE: IS IT FUNNY CURRENT? Angelo Giovanni Torrente , Audrey Zaini, Ashley Rosenberg, Rui Zhang, Jeanney Kang, Kenneth D. Philipson, Joshua I. Goldhaber Co-Chairs Stefan Howorka, University College London, United Kingdom Ian Derrington, University of Washington 3193-P lat 8:15 am MEMBRANE-SPANNING DNA NANOPORES. BIOMIMETIC CHEMICAL STRUCTURES FOR SINGLE-MOLECULE RESEARCH AND NANOTECHNOLOGY. Jonathan R. Burns, Kerstin Göpfrich, James W. Wood, Vivek V. Thacker, Ulrich F. Keyser, Eugen Stulz, Stefan Howorka 3194-P lat 8:30 am OPTICAL AND ELECTRICAL ANALYSIS OF SUSPENDED LIPID BILAYER MICROARRAYS FORMED BY MECHANICAL LIQUID SPREADING ON HORIZONTAL PLANAR MICROELECTRODE CAVITY ARRAYS. Juan Miguel Del Rio Martinez, Gerhard Baaken , Jan C. Behrends 3195-P lat 8:45 am MULTIPLEXED MICROFLUIDIC DEVICE FOR PARALLEL ELECTROPHYSIOLOGICAL MEASUREMENTS ON INDEPENDENT PLANAR LIPID BILAYERS. Alexander Prokofyev , Verena Stimberg, Johan Bomer, Hans de Boer, Albert van den Berg, Séverine Le Gac 8:15 am –10:15 am , R oom 304 Platform Micro- and Nanotechnology II

8:15 am –10:15 am , R oom 303 Platform Cardiac, Smooth, and Skeletal Muscle Electrophysiology

Co-Chairs Glenna Bett, State University of New York Gil Bub, University of Oxford, United Kingdom 3185-P lat 8:15 am

MYOCYTE STRETCH SLOWS CARDIAC CONDUCTION BY A CAVEOLAE-DEPENDENT INCREASE IN SARCOLEMMAL CAPACITANCE. Emily Pfeiffer , Adam Wright, Andrew Edwards, Jennifer Stowe, Katie McNall, Justin Tan, Hemal Patel, Jeffrey Omens, Andrew McCulloch

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Biophysical Society 58 th Annual Meeting, San Francisco, California