Program Book

3427-P os B oard #B155 EVIDENCE FOR FUNCTIONAL ROLE OF C-H···S HYDROGEN BOND IN ENZYME CATALYSIS AND SUBSTRATE SPECIFICITY: TYPE 1 METHIONINE AMINOPEPTIDASE. Anthony Addlagatta , Ravikumar Reddi 3428-P os B oard #B156 MONITORING CONFORMATIONAL CHANGES THAT OCCUR TO BLOOD COAGULANT PROTHROMBIN AS IT IS ACTIVATED TO THROMBIN. Muriel Maurer , Marina Malovichko 3429-P os B oard #B157 CHARACTERIZATION OF PROTEASES DERIVED FROM NEPHILA CLAVATA . Mitsutoshi Fujiwara , Mitsuhiro Miyazawa, Shigeru Shimamoto, Yuji Hidaka 3430-P os B oard #B158 STRUCTURAL AND COMPUTATIONAL STUDIES OF THE STAPHYLOCOCCUS AUREUS SORTASE B-SUBSTRATE COMPLEX PROVIDE NEW INSIGHT INTO THE MECHANISM OF SORTASE TRANSPEPTIDASES. Alex W. Jacobitz , Jeff Wereszczynski, Sung Wook Yi, Brendan R. Amer, Grace L. Huang, Angelyn V. Nguyen, Michael R. Sawaya, Michael E. Jung, J Andrew McCammon, Robert T. Clubb 3431-P os B oard #B159 THE ROLE OF CONFORMATIONAL COLLAPSE IN ENZYMIC CATALYSIS. Robert Callender , Huo-Lei Peng, Hua Deng, Brian Dyer 3432-P os B oard #B160 THE ROLE OF SUBSTRATE UNBINDING IN MICHAELIS-MEN- TEN ENZYMATIC REACTIONS. Shlomi Reuveni , Michael Urbakh, Joseph Klafter 3433-P os B oard #B161 APPLYING OSMOTIC STRESS REVEALS TWO MODES OF ENZYME INHIBITION. Oksana Yavorska, John K. Chik 3434-P os B oard #B162 PLACEHOLDER MECHANISM OF CATALYZED OXIDATIVE FOLDING IS CONSERVED ACROSS MULTIPLE DOMAINS OF LIFE. Thomas B. Kahn , Julio M. Fernandez, Raul Perez-Jimenez 3435-P os B oard #B163 KINETICS OF SEQUENTIAL ENZYME REACTIONS AND ELECTROSTATIC CHANNELING. Changsun Eun , Peter M. Kekenes-Huskey, Vincent T. Metzger, J. Andrew McCammon 3436-P os B oard #B164 SINGLE MOLECULE FORCE SPECTROSCOPY REVEALS FORCE-ENHANCED BINDING OF CALCIUM IONS BY GELSOLIN. Chunmei Lv, Xiang Gao, Wenfei Li, Robert Robinson, Meng Qin, Leslie Burtnick, Hao Zhou, Yi Cao , Wei Wang 3437-P os B oard #B165 SYNAPTOTAGMIN LINKER: TUNING OF COOPERATIVITY IN CALCIUM ION BINDING. Troy A. Hendrickson , Jacob W. Gauer, Ryan Mahling, Komemba J. Lohese, Michael E. Fealey, R. Bryan Sutton, Anne Hinderliter 3438-P os B oard #B166 MOLECULAR DYNAMICS-BASED PREDICTIONS OF THE STRUCTURAL AND FUNCTIONAL EFFECTS OF DISEASE-CAUSING CARDIAC TROPONIN MUTATIONS. Bairam Lotfalisalmasi , Charles M. Stevens, Glen F. Tibbits

3439-P os B oard #B167 DETERMINANTS OF PREFERENTIAL BINDING OF APO CALMODULIN TO THE IQ MOTIF OF NEURONAL SODIUM CHANNEL NAV1.2. Liam Hovey , Mark S. Miller, Dagan C. Marx, Kristin M. Tefft, Elaine Kim, Jesse B. Yoder, Madeline A. Shea 3440-P os B oard #B168 CALCIUM-MEDIATED REGULATION OF CALCINEURIN BY A DYNAMIC DUO OF EF-HAND PROTEINS. Madeline A. Shea , Sean A. Klein, Susan E. O’Donnell, Brett C. Waite, Jesse B. Yoder 3441-P os B oard #B169 FLUORESCENCE POLARIZATION AND FLUCTUATION ANALYSIS REVEALS COVERT CHANGES IN CAMKII HOLOENZYME ORGANIZATION TRIGGERED BY CALMODULIN AND CAMKIINTIDE. Tuan A. Nguyen , Jithesh V. Veetil, Pabak Sarkar, Steven S. Vogel 3442-P os B oard #B170 POSITIVE COOPERATIVITY AND T286 AUTOPHOSPHORYLATION IS OBSERVED IN A DIMERIC MUTANT OF CALCIUM-CALMODULIN DEPENDENT PROTEIN KINASE II (CAMKII). Pabak Sarkar , Kaitlin Davis, Henry L. Puhl III, Jithesh V. Veetil, Tuan A. Nguyen, Steven S. Vogel 3443-P os B oard #B171 CHARACTERIZATION OF CALCIUM-CALMODULIN KINASE II INHIBITOR PROTEIN (CAMKIIN) BY FLUORESCENCE POLARIZATION AND FLUCTUATION ANALYSIS. Jithesh V. Veetil , Kaitlin Davis, Henry L. Puhl III, Tuan A. Nguyen, Pabak Sarkar, Steven S. Vogel  Assemblies and Aggregates II (Boards #B172–#B201) 3444-P os B oard #B172 TWO-DIMENSIONAL INFRARED SPECTROSCOPY AND ELECTRON MICROSCOPY OF SEEDED AND NON-SEEDED AMYLOID β PEPTIDE FIBRILS. Jianqiang Ma, Hiroaki Komatsu , Paul H. Axelsen 3445-P os B oard #B173 A NEW QUANTITATIVE BEAD AGGREGATION ASSAY FOR DETERMINING THE ASSOCIATION RATES OF PROTEIN-PROTEIN INTERACTIONS. Nagamani Vunnam , Natalie René Phongam, Ashton Walters, Nathan Hammer, Susan Pedigo 3446-P os B oard #B174 STRUCTURAL AND HYDRATION PROPERTIES OF HUNTINGTIN AGGREGATES DETERMINED BY SMALL-ANGLE NEUTRON SCATTERING. Christopher B. Stanley , Tatiana Perevozchikova, Helen P. McWilliams-Koeppen, Valerie Berthelier 3447-P os B oard #B175 ENHANCEMENT, EQUAL FLUORESCENCE EFFICIENCY, AND QUENCHING IN THE INTERPRETATION OF FLUORESCENCE ANISOTROPY DATA. Zahra Zolmajd-Haghighi, Quentin Hanley 3448-P os B oard #B176 education travel awardee CHARGE CROWDING PROMOTES SELF-ASSEMBLY OF COLLAGEN HETROTRIMERS. Nida F. Hasan , Avanish S. Parmar, Mihir Joshi, Patrick Nosker, Vikas Nanda 3449-P os B oard #B177 UREA, GUANIDINE HYDROCLORIDE AND 2,2,2- TRIFLUOROETHANOL CAN CHANGE THE AMYLOID FIBRIL FORMATION OF MODEL PROTEINS: A SPECTROSCOPIC STUDY. Leandro R S Barbosa

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Biophysical Society 58 th Annual Meeting, San Francisco, California