Program Book

189-S ymp 4:20 pm CRYSTAL STRUCTURES OF ACTIVATED G-PROTEIN COUPLED RECEPTORS. WilliamWeis 190-S ymp 4:40 pm COMBINING CRYSTALLOGRAPHIC AND STRUCTURE- MODELING APPROACHES IN MACROMOLECULAR CRYSTALLOGRAPHY. Thomas C. Terwilliger , Frank DiMaio, Randy J. Read, David Baker, Axel T. Brunger, Paul D. Adams, Pavel V. Afonine, Li-Wei Hung 191-S ymp 5:00 pm STRUCTURES OF THE UNIVERSAL TRANSLATOR, THE RIBOSOME. Jamie H. D. Cate 192-S ymp 5:20 pm XFELS FOR IMAGING MOLECULAR DYNAMICS. John Spence 193-S ymp 5:40 pm THE NEXT 100 YEARS OF CRYSTALLOGRAPHY: HOW THE HECK SHOULD I KNOW? Gregory A. Petsko 4:00 pm –6:00 pm , R oom 130/131 Symposium Liquid Protein Assemblies in Spatial Organization and Ultrasensitive Signaling in Cells Co-Chairs PHASE SEPARATION OF DISORDERED PROTEIN IN THE FOR- MATION OF MEMBRANE-LESS ORGANELLES. Timothy J. Nott, Patrick Farber, Evangelia Petsalakis, Dylan Jervis, Andrew J. Baldwin, Julie D. Forman-Kay 195-S ymp 4:30 pm THE LIQUID STATE OF (ELASTOMERIC) PROTEINS. Régis Pomès 196-S ymp 5:00 pm DECODING MOLECULAR PLASTICITY UNDERLYING NUCLEOCYTOPLASMIC TRANSPORT: FROM SINGLE MOLECULES TO LARGE ASSEMBLIES. Edward A. Lemke 197-S ymp 5:30 pm PHASE SEPARATION OF MULTI-VALENT SIGNALING PROTEINS. Michael K. Rosen Julie Forman-Kay, Hospital for Sick Children, Canada Tanja Mittag, St. Jude Children’s Research Hospital 194-S ymp 4:00 pm

200-P lat 4:30 pm SINGLE-PARTICLETRACKING PALMOF NAV1.6 INHIPPOCAMPAL NEURONS DEMONSTRATES UNIQUE SUBCELLULAR DIFFUSION LANDSCAPES. Elizabeth J. Akin , Kristen Brown, Sanaz Sadegh, Aubrey V. Weigel, Jean-Baptiste Masson, Diego Krapf, Michael M. Tamkun 201-P lat 4:45 pm β 4 MODULATES NA V 1.2 TOXIN PHARMACOLOGY. John M. Gilchrist , Samir Das, Filip Van Petegem, Frank Bosmans 202-P lat 5:00 pm DISTINCT VOLTAGE SENSOR GATING OF CARDIAC NA V CHANNELS. Zoltan Varga , Angela R. Schubert, Alexandra B. Asaro, Jianmin Cui, Mark A. Zaydman, Colin G. Nichols, Jonathan R. Silva 203-P lat 5:15 pm CRYSTAL STRUCTURE OF THE NAV β 4 EXTRACELLULAR DOMAIN. Samir Das , John Gilchrist, Frank Bosmans, Filip Van Petegem 204-P lat 5:30 pm MOLECULAR DYNAMICS STUDIES OF ION CONDUCTION IN A PROKARYOTIC CHANNEL. Karen M. Callahan , Benoit Roux 205-P lat 5:45 pm PHOSPHOPROTEOMIC IDENTIFICATION OF CAMKII- AND HEART FAILURE-DEPENDENT PHOSPHORYLATION SITES ON THE NATIVE CARDIAC NAV1.5 CHANNEL PROTEIN. Fabien Coyan, Sophie Burel, Cheryl F. Lichti, Joan H. Brown, Flavien Charpentier, Jeanne M. Nerbonne, Reid R. Townsend, Lars M. Maier, Céline Marionneau CONFORMATIONAL DYNAMICS DURING GPCR - G PROTEIN COUPLING. Alexander S. Rose , Matthias Elgeti, Patrick Scheerer, Ulrich Zacchariae, Martin Heck, Franz J. Bartl, Helmut Grubmüller, Klaus P. Hofmann, Peter W. Hildebrand 207-P lat 4:15 pm MODELING AND INHIBITOR DESIGN OF CA( 2+ )-INDEPENDENT PHOSPHOLIPASE A2. Denis Bucher , Varnavas D. Mouchlis, Edward A. Dennis, J Andrew McCammon 208-P lat 4:30 pm MEMBRANE DEPENDENCE OF THE MECHANOSENSITIVE CHANNEL OF LARGE CONDUCTANCE. Helgi I. Ingólfsson , Clement Arnarez, Neeraj Kumar, Martin Walko, Herman J. C. Berendsen, Armağan Koçer, Siewert J. Marrink 209-P lat 4:45 pm UNDERSTANDING THE SPECIAL PROPERTIES OF [NIFESE] HYDROGENASES THROUGH THE USE OF COMPUTATIONAL METHODOLOGIES. Carla SA Baltazar , Victor H. Teixeira, Cláudio M. Soares 210-P lat 5:00 pm STRUCTURAL INSIGHTS ON THE STATHERIN N-TERMINAL 4:00 pm –6:00 pm , R oom 303 Platform Molecular Dynamics I Co-Chairs Cameron Mura, University of Virginia Karissa Sanbonmatsu, Los Alamos National Laboratory 206-P lat 4:00 pm

4:00 pm –6:00 pm , R oom 132/133 Platform Voltage-gated Na Channels

Co-Chairs Bonnie Wallace, Birkbeck College, United Kingdom Jonathan Silva, Washington University in St. Louis 198-P lat 4:00 pm

STRUCTURE/FUNCTION INSIGHTS INTO EUKARYOTIC CHANNEL BLOCKER BINDING SITES IN A PROKARYOTIC SODIUM CHANNEL. Claire Bagnéris , Claire E. Naylor, Paul G. DeCaen, David E. Clapham, David Pryde, B. A. Wallace 199-P lat 4:15 pm INTRACELLULAR CALCIUM ATTENUATES PERSISTENT CURRENT CONDUCTED BY MUTANT HUMAN CARDIAC SODIUM CHANNELS IN LONG-QT SYNDROME. Franck Potet , Thomas M. Beckermann, Jennifer D. Kunic, Alfred L. George

BINDING DOMAIN IN THE ADSORBED STATE. Michael Deighan , Tobias Weidner, Jim Pfaendtner

22

Biophysical Society 58 th Annual Meeting, San Francisco, California