Program Book

667-P os B oard #B422 EFFECTS OF THE PROTONATION STATES OF THE EEEE MOTIF OF A BACTERIAL NA + -CHANNEL ON CONDUCTION AND PORE STRUCTURE. Carmen Domene , Simone Furini 668-P os B oard #B423 STRUCTURE OF A PROKARYOTIC SODIUM CHANNEL PORE REVEALS ESSENTIAL GATING ELEMENTS AND AN OUTER ION BINDING SITE COMMONTO EUKARYOTIC CHANNELS. Cristina Arrigoni , David Shaya, Felix Findeisen, Fayal Abdermane-Ali, Gildas Loussouarn, Daniel L. Minor 669-P os B oard #B424 UNCOVERING THE LINKS BETWEEN CONFORMATIONAL FLEXIBILITY AND FUNCTION FOR A BACTERIAL VOLTAGE-GATED SODIUM CHANNEL. Céline Boiteux, Igor Vorobyov, Toby W. Allen 670-P os B oard #B425 STRUCTURAL MODELING OF TOXIN INTERACTIONS WITH THE HUMAN VOLTAGE-GATED SODIUM CHANNEL PORE. Phuong T. Nguyen , Jon T. Sack, Toby W. Allen, Vladimir Yarov-Yarovoy 671-P os B oard #B426 FINDING THE ROUTE OF ENTRY AND BINDING SITE OF LOCAL ANAESTHETICS IN BACTERIAL VOLTAGE GATED SODIUM CHANNELS USING MOLECULAR DYNAMICS SIMULATION. Lewis Martin, Ben Corry 672-P os B oard #B427 A NOVEL GATING MECHANISM OF THE NAVMS SELECTIVITY FILTER SUGGESTED BY MOLECULAR DYNAMICS SIMULATIONS. Song Ke , Anna Stary-Weinzinger 673-P os B oard #B428 CONGRUENT PATTERN OF ACCESSIBILITY WITHIN THE PORE OF A VOLTAGE-GATED NA + CHANNEL. Kevin Oelstrom , Baron Chanda 674-P os B oard #B429 CATALYSIS AND SELECTIVITY OF NA + PERMEATION IN BACTERIAL SODIUM CHANNEL NAVAB. Christopher Ing , Nilmadhab Chakrabarti, Jian Payandeh, Ning Zheng, William A. Catterall, Régis Pomès 675-P os B oard #B430 THE ORIGINS OF ION SELECTIVITY IN A BACTERIAL SODIUM CHANNEL REVEALED BY µS-LONG SIMULATIONS. Celine Boiteux , Igor Vorobyov, Toby W. Allen 676-P os B oard #B431 CHARACTERIZING NA + /K + PERMEATION RATES THROUGH THE BACTERIAL NAVAB SODIUM CHANNEL. Leticia Stock , Vincenzo Carnevale, Werner Treptow, Michael L. Klein 677-P os B oard #B432 NEGATIVE COUNTERCHARGES AND S4 INTERACTION IN DOMAIN IV OF NAV1.4. James R. Groome 678-P os B oard #B433 MODULATION OF INACTIVATION KINETICS OF THE BACTERIAL SODIUM CHANNEL NACHBAC SUGGESTS A COMPLEX MODE OF INHIBITION BY ISOFLURANE. Rheanna Sand , Tamar Macharadze, Hugh Hemmings, Jr. 679-P os B oard #B434 PHARMACOLOGICAL PROPERTIES OF CINNAMALDEHYDE ON NACHBAC. Divya Kesters , Jan Tytgat, Thomas Voets, Karel Talavera, Chris Ulens

656-P os B oard #B411 MULTIPLE REGIONS OF JUNCTIN AND TRIADIN INTERACT WITH CALSEQUESTRIN 1 AND 2 IN SKELETAL MUSCLE CELLS. Daniela Rossi , Angela Maria Scarcella, Stefania Lorenzini, Vincenzo Sorrentino 657-P os B oard #B412 TEMPERATURE EFFECTS ON THE MYOPLASMIC FREE CA 2+ TRANSIENTS IN FDB MUSCLE FIBERS OF THE MOUSE. Alexis Ruiz, Juan Camilo Calderon, Pura Bolaños, Carlo Caputo 658-P os B oard #B413 CELLULAR MECHANISMS OF CARDIAC DEPRESSION AND RECOVERY IN ENDOTOXEMIC MICE. Justin C. Morse , Deborah A. Siwik, Wilson S. Colucci, Ion A. Hobai 659-P os B oard #B414 CONDITIONAL UP-REGULATION OF SERCA2A EXACERBATES VENTRICULAR AND ATRIAL ARRHYTHMIAS IN THE SETTING OF CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA. Bin Liu , Qing Lou, Florencia Velez-Cortes, Omid Sayadi, Wolfgang Dillmann, Björn Knollmann, Antonis Armoundas, Sandor Gyorke 660-P os B oard #B415 FRACTAL-LIKE BEHAVIOR OF THE HEART-BEAT INTERVALS IS ENCODED WITHIN INTRINSIC COMPLEXITY OF PACEMAKER CELLS RESIDING INTHE SINOATRIAL NODE ANDMODULATED BY AUTONOMIC INPUT TO THE HEART. Yael Yaniv , Ismayil Ahmet, Liu Jie, Toni-Rose Guiriba, Yosuke Okamoto, Edward G. Lakatta 661-P os B oard #B416 THE MSTN-CMPT DL1ABC- MICE. A MOUSE MODEL TO STUDY MUSCLE WEAKNESS, FATIGUE AND SOCE. Mónika Sztretye , Nikolett Geyer, Dana AlGhaadi, Dóra Bodnár, Tamás Oláh, Beatrix Dienes, Ildikó Balatoni, Péter Szentesi, László Csernoch 662-P os B oard #B417 STIM1 REGULATES SARCOPLASMIC RETICULUM CA 2+ -ATPASE 1A (SERCA1A) IN SKELETAL MUSCLE. Keon Jin Lee , Changdo Hyun, Jin Seok Woo, Chang Sik Park, Do Han Kim, Eun Hui Lee 663-P os B oard #B418 ACCELERATED ACTIVATION OF SOCE CURRENT IN MYO- TUBES FROM TWO MOUSE MODELS OF ANESTHETIC- AND HEAT-INDUCED SUDDEN DEATH. Viktor Yarotskyy , Feliciano Protasi, Robert T. Dirksen 664-P os B oard #B419 INWARD RECTIFIER POTASSIUM CHANNELS IN MAMMALIAN SKELETAL MUSCLE FIBERS. Julio L. Vergara , Marbella Quiñonez, Carl Yu, Marino DiFranco 665-P os B oard #B420 STIM1 ENHANCES SR CA 2+ REFILLING THROUGH ACTIVAT- ING SERCA2A IN RAT VENTRICULAR MYOCYTES. Guiling Zhao , Didier X. P. Brochet, Tianyu Li, Paul Rosenberg, W. Jonathan Lederer  Voltage-gated Na Channels I (Boards #B421-#B438) 666-P os B oard #B421 NAVAB STRUCTURE AS A TEMPLATE TO RATIONALIZE EXPERIMENTAL DATA ON NAV1.4 BLOCK BY MU-CONOTOXINS. Vyacheslav S. Korkosh, Boris S. Zhorov , Denis B. Tikhonov

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Biophysical Society 58 th Annual Meeting, San Francisco, California