Program Book

10:45 am –12:45 pm , R oom 132/133 Platform Mechanisms of Voltage Sensing and Gating Co-Chairs Simon Berneche, University of Basel, Switzerland Brad Rothberg, Temple University School of Medicine 1178-P lat 10:45 am GATING CURRENTS OF MONOMERIC HV CHANNEL REVEALS A PERMEATION PATHWAY COUPLED TO THE VOLTAGE ACTIVATION. David Baez-Nieto , Ester Otarola, Gustavo Contreras, Peter Larsson, Ramon Latorre, Carlos Gonzalez 1179-P lat 11:00 am THE SPECIALIZED ROLE OF THE S1 TRANSMEMBRANE SEGMENT IN THE GATING OF THE HV1 PROTON CHANNEL. Laetitia Mony , Thomas K. Berger, Ehud Y. Isacoff 1180-P lat 11:15 am OPTICALLY MAPPING THE MOVEMENT OF DISCRETE GATING CHARGES IN SHAKER. Michael F. Priest , Francisco Bezanilla 1181-P lat 11:30 am MULTI-DIMENSIONAL FREE ENERGY LANDSCAPE OF VOLTAGE SENSOR DOMAIN ACTIVATION. Lucie Delemotte , Marina Kasimova, Vincenzo Carnevale, Michael L. Klein, Mounir Tarek 1182-P lat 11:45 am PROTEIN BACKBONE MUTAGENESIS REVEALS A NOVEL LINK BETWEEN ION OCCUPANCY AND C-TYPE INACTIVATION IN K + CHANNELS. Kimberly Matulef , Alexander G. Komarov, Francis I. Valiyaveetil 1183-P lat 12:00 pm REGULATION OF ION PERMEATION IN THE SELECTIVITY FILTER OF POTASSIUM CHANNELS. Simon Berneche , Wojciech Wojtas-Niziurski, Florian Heer 1184-P lat 12:15 pm INITIAL STEPS OF INACTIVATION AT THE K + CHANNEL SELECTIVITY FILTER. Andrew S. Thomson, Florian T. Heer, Frank J. Smith, Simon Berneche, Brad S. Rothberg 1185-P lat 12:30 pm MAPPING CONFORMATIONAL STATES IN VDAC1 CHANNEL: COMPLEXITY OF GATING LANDSCAPE. Sergei Noskov , Oscar Teijido Hermida, Tatiana Rostovtseva, Bezrukov Sergei

1168-S ymp 11:15 am TARGETING INFLUX TRANSPORTERS IN THE HUMAN BLOOD BRAIN BARRIER. Kathleen Giacomini 1169-S ymp 11:45 am NONINVASIVE PERSONALIZED GENOMICS. Charles Cantor 1170-S ymp 12:15 pm TRANSLATING A TRILLION POINTS OF DATA INTO THERAPIES, DIAGNOSTICS, AND NEW INSIGHTS INTO DISEASE. Atul J. Butte

10:45 am –12:45 pm , R oom 135 Symposium Stochasticity in Cellular Processes

Co-Chairs Rachel Kuske, University of British Columbia, Canada Nathalie Questembert-Balaban, Hebrew University of Jerusalem, Israel N o A bstract 10:45 am ON THE STATISTICAL NATURE OF BEHAVIORAL DIVERSITY. Stanislas Leibler 1171-S ymp 11:15 am STOCHASTIC BISTABILITY AND SWITCHING IN VIRUS/ IMMUNE CELL NETWORKS. Elizabeth Read 1172-S ymp 11:45 am RELIABILITY OF NOISE-INDUCED SPIKES FOR TWO TYPES OF THRESHOLD DYNAMICS. Rachel Kuske , Na Yu, Yue Xian Li 1173-S ymp 12:15 pm DETERMINISTIC VERSUS STOCHASTIC VARIABILITY IN THE MAMMALIAN CELL CYCLE. Sivan Pearl, Oded Sandler, Oded Agam, Itamar Simon, Nathalie Q. Balaban Co-Chairs Marileen Dogterom, AMOLF, The Netherlands Kazuhiro Oiwa, National Institute of Information and Communications Technology, Japan 1174-S ymp 10:45 am MECHANISTIC INSIGHTS OF DYNEIN MOTOR ACTION FROM ELECTRON MICROSCOPY STUDIES. Stanley A. Burgess, Takahide Kon, Peter J. Knight, Kazuo Sutoh 1175-S ymp 11:15 am RECONSTITUTION OF DYNAMIC AXONEMAL COMPLEXITY WITH USING A BOTTOM UP STRATEGY. Kazuhiro Oiwa 1176-S ymp 11:45 am DYNEIN-MEDIATED POSITIONING OF MICROTUBULE ASTERS IN 3D CONFINEMENT. Sophie Roth, Marileen Dogterom 1177-S ymp 12:15 pm NEW METHODS FOR MOLECULAR MOTOR AND CELL MOTILITY RESEARCH. Adam G. Hendricks, John F. Beausang, John H. Lewis, Lisa Lippert, Deborah Shroder, E. Michael Ostap, Erika L.F. Holzbaur, Yale E. Goldman 10:45 am –12:45 pm , R oom 130/131 Symposium Regulation of Cytoskeletal Motors

10:45 am –12:45 pm , R oom 303 Platform: Member-Organized Session Mechanics at the Cell Surface

Co-chairs Jesse Goyette, Oxford University, United Kingdom Jun Allard, University of California, Irvine 1186-P lat 10:45 am

ANTIGEN-SPECIFIC TCR-PMHC CATCH TRIGGERS T-CELL SIGNALING BY RAPIDLY ACCUMULATING SUCCESSIVE BOND LIFETIMES PROLONGED BY OPTIMAL FORCE. Baoyu Liu, Wei Chen, Brian D. Evavold, Cheng Zhu 1187-P lat 11:00 am HOW CELLULAR GEOMETRY REGULATES TRACTION STRESSES IN ADHERENT CELLS. Patrick W. Oakes , Shiladitya Banerjee, M. Cristina Marchetti, Margaret L. Gardel

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Biophysical Society 58 th Annual Meeting, San Francisco, California