Program Book

1730-P os B oard #B460 DIRECT INTERACTION OF RIC-3 WITH THE INTRACELLULAR DOMAIN OF EUKARYOTIC CATIONIC PENTAMERIC LIGAND-GATED ION CHANNELS. Sita Nirupama Nishtala , Nelli Mnatsakanyan, Michaela Jansen 1731-P os B oard #B461 THE PROKARYOTE LIGAND-GATED ION CHANNEL ELIC CAPTURED IN A PORE BLOCKER-BOUND CONFORMATION BY THE ALZHEIMER’S DISEASE DRUG MEMANTINE. Chris Ulens, Radovan Spurny , Andrew J. Thompson, Mona Alqazzaz, Sarah Debaveye, Han Lu, Kerry Price, Jose M. Villalgordo, Gary Tresadern, Gary Tresadern, Joseph W. Lynch, Joseph W. Lynch, Sarah C. R. Lummis 1732-P os B oard #B462 PROBING PENTAMERIC LIGAND-GATED ION CHANNELS WITH BROMOFORM REVEALS MANY INTERCONNECTED ANESTHETIC BINDING SITES. Benoist Laurent, Samuel Murail , Ludovic Sauguet, Marc Delarue, Marc Baaden 1733-P os B oard #B463 MOLECULAR INSIGHTS INTO THE GATING MECHANISM OF GLIC, A PROKARYOTIC LIGAND-GATED ION CHANNEL. Mehrnoosh Arrar , Iman Pouya, James Andrew McCammon, Erik Lindahl 1734-P os B oard #B464 LIGAND-GATED ION CHANNEL GATING KINETICS AND THE OPENING/CLOSING MECHANISM ARE SENSITIVE TO MUTATIONS ALTERING THE HYDROPHOBICITY OF THE ION CONDUCTION PORE. Goran Klement , Iman Pouya, Özge Yoluk, Rebecca Howard, Erik Lindahl 1735-P os B oard #B465 ALTERING THE OPEN VS. CLOSED STATE BALANCE OF THE GLIC LIGAND-GATED ION CHANNELTHROUGHMUTAGENESIS ENABLES MOLECULAR SIMULATION OF THE REVERSIBLE GATING PROCESS. Iman Pouya, Göran Klement, Samuel Murail, Peter Kasson, Özge Yoluk, Erik Lindahl 1736-P os B oard #B466 STRUCTURAL BASIS FOR ALLOSTERIC TRANSITIONS IN THE GLIC PENTAMERIC PROTON-GATED ION CHANNEL. Ludovic Sauguet , Azadeh Shahsavar, Frederic Poitevin, Christele Huon, Anais Menny, Akos Nemecz, Ahmed Haouz, Jean-Pierre Changeux, Pierre-Jean Corringer, Marc Delarue Cardiac Muscle I (Boards #B467–#B498) 1737-P os B oard #B467 EFFECT OF PIMOBENDAN ON HEART FAILURE IN A MOUSE MODEL INHERITED CARDIOMYOPATHY. Miki Nonaka , Kengo Hayamizu, Sachio Morimoto 1738-P os B oard #B468 EFFECTS OF CHRONIC MYOCARDIAL INFARCTION ON CARDIACMUSCLE PERFORMANCE AND STRUCTURE IN-VIVO AND IN-VITRO. Christopher Toepfer , Markus Sikkel, Valentina Caorsi, O’Neal Copeland, Iratxe Torre Martinez, Timothy West, Steve Marston, Pradeep Luther, Alexander Lyon, Kenneth Macleod, Michael Ferenczi 1739-P os B oard #B469 ELUCIDATING THE ROLE OF MYOSIN PSEUDO- PHOSPHORYLATION IN A NOVEL RESCUE MOUSE MODEL OF CARDIOMYOPATHY. Priya Muthu , Chen-Ching Yuan, Katarzyna Kazmierczak, Jingsheng Liang, Ana Isabel Rojas, Danuta Szczesna-Cordary

1740-P os B oard #B470 AGE-RELATED CARDIAC DYSFUNCTION IN TRANSGENIC MICE CARRYING ACTIN E99K MUTATION. Li Wang , Weihua Song, Andrew Messer, Steven Marston, Masataka Kawai 1741-P os B oard #B471 DETAILED HEMODYNAMIC CHARACTERIZATION OF ATHLETE’S HEART USING LEFT VENTRICULAR PRESSURE- VOLUME ANALYSIS IN A RAT MODEL. Dalma Kellermayer , Attila Oláh, Árpád Lux, Balázs Tamás Németh, László Hidi, Ede Birtalan, Mihály Ruppert, Csaba Mátyás, Béla Merkely, Tamás Radovits 1742-P os B oard #B472 INCORPORATION OF TROPONIN C WITH MODIFIED CA 2+ BINDING INTO THE HEART THROUGH THE USE OF ADENO-ASSOCIATED VIRUS LEADS TO ALTERED HEART FUNCTION. Vikram Shettigar, Sean C. Little, Jianchao Zhang, Steve R. Roof, Mark T. Ziolo, Brandon J. Biesiadecki, Jonathan P. Davis 1743-P os B oard #B473 CROSSING MICE CARRYING TNT DISEASE MUTATIONS WITHOPPOSITE EFFECTS ONTHE MYOFILAMENT CALCIUM SENSITIVITY PARTIALLY NORMALIZES MYOFILAMENT FUNCTION AND AMELIORATES CARDIOMYOPATHY PHENOTYPES. Rajdeep S. Turna , Rebecca S. Weller, Hyun-Seok Hwang, David Dweck, Ferhaan Ahmad, Sabine Huke, Björn C. Knollmann, Jose Renato Pinto 1744-P os B oard #B474 IMPACT OF E163R CTNT MUTATION ON CARDIAC MECHANICS AND ENERGETICS IN A MURINE MODEL. Benedetta Tosi , Cecilia Ferrantini, José Manuel Pioner, Claudia Ferrara, Beatrice Scellini, Nicoletta Piroddi, Salwa Abdullah, Coppini Raffaele, Sara Bardi, Jill Tardiff, Chiara Tesi, Corrado Poggesi 1745-P os B oard #B475 AAV6-MEDIATED OVEREXPRESSION OF RIBONUCLEOTIDE REDUCTASE (R1R2) ENHANCES 2-DEOXY-ATP CONCENTRATION IN VIVO AND IMPROVES CARDIAC FUNCTION. Elizabeth Gay , Sarah G. Nowakowski, Stephen C. Kolwicz, Guy L. Odom, Galina V. Flint, Rudy Stuppard, Haiwei Gu, Jeffrey S. Chamberlain, Daniel Raftery, Rong Tian, David J. Marcinek, Michael Regnier 1746-P os B oard #B476 TITIN-BASED PASSIVE TENSION IS INCREASED IN A TITIN AI KO MOUSE. Rebecca Slater , Kirk Hutchinson, Mei Methawasin, Henk L. Granzier 1747-P os B oard #B477 MYOCARDIAL TITIN: AN IMPORTANT MODIFIER OF CARDIAC STIFFNESS. Nazha Hamdani , Wolfgang A. Linke 1748-P os B oard #B478 A GAIN-OF-FUNCTION MUTATION IN CARDIAC MYOSIN BINDING PROTEIN-C INCREASES VISCOELASTIC LOAD AND SLOWS SHORTENING VELOCITY IN MYOCYTES FROM TRANSGENIC MICE. Kristina L. Bezold , Jaskiran K. Khosa, Samantha P. Harris 1749-P os B oard #B479 EXERCISE-INDUCED ENHANCEMENT OF CARDIAC AND SARCOMERE PERFORMANCE IS LARGER IN MALE THAN IN FEMALE MYBPC3 MUTATION HETEROZYOUS KNOCK-IN MICE. Aref Najafi , Saskia Schlossarek, Elza van Deel, Nikki van den Heuvel, Ahmet Güçlü, Max Goebel, Nicky Boontje, Diederik Kuster, Lucie Carrier, Jolanda Van der Velden

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Biophysical Society 58 th Annual Meeting, San Francisco, California