Program Book

1750-P os B oard #B480 GENDER DIFFERENCES IN PASSIVETENSION IN HYPERTROPHIC CARDIOMYOPATHY PATIENTS. Louise L.A.M. Nijenkamp , Jessica A. Regan, Michelle Michels, Chris dos Remedios, Carolyn H. Ho, Jolanda van der Velden 1751-P os B oard #B481 SEX-RELATED DIFFERENCES IN MYOSIN HEAVY CHAIN ISOFORMS OF HUMAN FAILING AND NON-FAILING ATRIA. Peter J. Reiser , Christine S. Moravec 1752-P os B oard #B482 MYOCARDIAL INFARCTION-INDUCED N-TERMINAL FRAGMENT OF CMYBP-C IMPAIRS MYOFILAMENT FUNCTION IN HUMAN LEFT VENTRICULAR MYOFIBRILS. Namthip Witayavanitkul , Jason Sarkey, Younss Aitmou, Diederik W.D. Kuster, Ramzi J. Khairallah, Suresh Govindan, Xin Chen, Ying Ge, Sudarsan Rajan, David F. Wieczorek, Thomas Irving, Pieter P. de Tombe, Sakthivel Sadayappan 1753-P os B oard #B483 BETA-ADRENERGIC RESPONSE IN HUMAN HCM MYOCARDIUM: EFFECTS OF RANOLAZINE. Cecilia Ferrantini , Raffaele Coppini, Benedetta Tosi, Josè Manuel Pioner, Laura Sartiani, Iacopo Olivotto, Chiara Tesi, Luiz Belardinelli, Elisabetta Cerbai, Alessandro Mugelli, Corrado Poggesi 1754-P os B oard #B484 DEPRESSED CONTRACTILITY AT LOW-LOAD SPONTANEOUS OSCILLATORY CONTRACTIONS IN HUMAN HYPERTROPHIC CARDIOMYOPATHY WITH MYBPC3 MUTATIONS. Amy Li , J. Martijn Bos, Michael J. Ackerman, Filip Braet, Murat Kekic, Shin’ichi Ishiwata, Cristobal G. dos Remedios 1755-P os B oard #B485 THE ROLE OF CARDIAC MYOSIN LIGHT CHAIN 2V PHOSPHORYLATION IN THE HEALTHY AND FAILING MYOCARDIUM. Ramzi J. Khairallah , Namthip Witayavanitkul, Mohit Kumar, Mengjie Zhang, Pieter de Tombe 1756-P os B oard #B486 EXISTENCE OF LENGTH-DEPENDENT MODULATION OF CROSS-BRIDGE CYCLING KINETICS IN RIGHT VENTRICLES OF NON-FAILING AND FAILING HUMAN MYOCARDIUM. Nima Milani-Nejad , Jonathan P. Davis, Vadim V. Fedorov, Peter J. Mohler, Ahmet Kilic, Robert S.D. Higgins, Paul M.L. Janssen 1757-P os B oard #B487 INCREASED CAMKII ACTIVITY IMPAIRS CONTRACTILE FUNCTION IN HUMAN HCM MYOCARDIUM. Raffaele Coppini , Cecilia Ferrantini, Manuel J. Pioner, Lina Yao, Peidong Fan, Benedetta Tosi, Elisabetta Cerbai, Luiz Belardinelli, Chiara Tesi, Corrado Poggesi 1758-P os B oard #B488 THE CARDIAC TROPONIN T R92L HCM MUTATION ALTERS CARDIACTROPONIN I DYNAMICS AND PKA PHOSPHORYLATION POTENTIAL. Jayant James Jayasundar , Kenneth Brooks, Sarah Lehman, Michael R. Williams, Jil C. Tardiff 1759-P os B oard #B489 CONFORMATIONAL AND FUNCTIONAL EFFECTS OF PATHOGENIC MUTATIONS AT THE I-T INTERFACE OF CARDIAC TROPONIN I. Shirin Akhter , J. -P Jin

1760-P os B oard #B490 COMPUTATIONAL PREDICTION AND EXPERIMENTAL VERIFICATION OF DIFFERENTIAL CALCIUM AFFINITY IN THIN FILAMENT MUTANTS KNOWNTO CAUSE HYPERTROPHIC CARDIOMYOPATHY. Edward P. Manning, Sarah J. Lehman , Steven D. Schwartz, Jil C. Tardiff 1761-P os B oard #B491 CA 2+ -INDUCED STRUCTURAL CHANGES INTN: A MULTI-SITE FRET STUDY COMBININGTCSPCWITH SINGLE FILAMENT IMAGING. Maria E. Moutsoglou , Gi-Ho Kim, Christopher Solis-Ocampo, Steven C. Wu, John M. Robinson 1762-P os B oard #B492 PARTIAL ACTIVATION OF THE CARDIAC MYOFILAMENT BY CA 2+ . Mathivanan Chinnaraj 1763-P os B oard #B493 MODULATION OF THE INTERACTION BETWEEN TROPONIN I N-TERMINAL PEPTIDE AND TROPONIN C BY PHOSPHORYLATION STUDIED BY MOLECULAR DYNAMICS. Ian Gould, Andrew E. Messer, Maria Papadaki, Steven B. Marston 1764-P os B oard #B494 CARDIAC TROPONIN I A164H AND PH-DEPENDENT INOTROPY. Anthony D. Vetter , Brian Thompson, Joseph M. Muretta, David D. Thomas, Joseph M. Metzger 1765-P os B oard #B495 MOLECULAR MECHANISM OF CARDIOMYOPATHY-CAUSING MUTATIONS IN ALPHA-TROPOMYOSIN. Tejas M. Gupte , Farah Haque, Binnu Gangadharan, Margaret Sunitha, Suman Nag, Sowdhamini R, VijayRaghavan K, James A. Spudich, John A. Mercer 1766-P os B oard #B496 SKELETAL MUSCLE MYOPATHY MUTATIONS INTROPOMYOSIN GENETPM3 AFFECTTHIN FILAMENTTRANSITIONS BETWEEN THE INACTIVE AND ACTIVE STATES. Mohammed El-Mezgueldi, Saeed Asiri, Widad Albishri, Kristen Nowak 1767-P os B oard #B497 DIRECT VISUALIZATION OF COOPERATIVE BINDING OF TROPONIN-TROPOMYOSIN TO F-ACTIN. Christopher Solis-Ocampo , Maria Moutsoglou, Gi-Ho Kim, John M. Robinson 1768-P os B oard #B498 THE ACCURACY OF CARDIAC MYOFILAMENT SIMULATIONS IS ENHANCED BY PERMITTING CALCIUM-INDEPENDENT TROPOMYOSIN TRANSITIONS. Yasser Aboelkassem, Kimberly McCabe, Stuart G. Campbell  Microtubules, Their Motors and Associated Proteins I (Boards #B499–#B524) 1769-P os B oard #B499 TUBULIN HETERODIMERS REVERSIBLY DISSOCIATE WITH MODERATE KINETICS AS DEMONSTRATED USING SEDI- MENTATION VELOCITY ANALYTICAL ULTRACENTRIFUGA- TION. Felipe Montecinos-Franjola , Dan L. Sackett, Peter Schuck 1770-P os B oard #B500 STUDYING THE STRUCTURAL ORIGINS OF MICROTUBULE DYNAMIC INSTABILITY THROUGH COMBINING COMPU- TATIONAL MODELING AND CRYOEM. Elizabeth H. Kellogg , Gregory M. Alushin, Gabriel C. Lander, David Baker, Eva Nogales

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Biophysical Society 58 th Annual Meeting, San Francisco, California