Understanding Periperal Membrane Protein Interactions | BPS Thematic Meeting

Understanding Peripheral Membrane Protein Interactions: Structure, Dynamics, Function and Therapy

Wednesday Speaker Abstracts

FERROPTOTIC INTERACTIONS OF PERIPHERAL MEMBRANE PROTEINS WITH SMALL MOLECULES AND LIPIDS Ivet Bahar 1 ; Carlos Ventura 1 ; Karolina Mikulska-Ruminska 2 ; Xiaowei Bogetti 1 ; Jiyoung Lee 1 ; Hulya Bayir 3 ; Valerian Kagan 4 ; 1 Stony Brook University, STONY BROOK, NY, USA

2 Nicolaus Copernicus University, Torun, Poland 3 Columbia University, New York, NY, USA 4 University of Pittsburgh, Pittsburgh, PA, USA

Recent years have seen a surge in the number of studies focusing on proteins involved in ferroptotic events, with the realization of the importance of promoting or inhibiting ferroptosis as a strategy to combat a wide variety of diseases, ranging from traumatic brain injury to metastatic cancer. Among proteins that garnered interest, 15-lipoxygenases, that catalyze the peroxidation of PUFA-conjugated PE (phosphatidyl ethanol amine) and ferroptosis suppressor protein 1 (FSP1), both peripheral membrane proteins, have been two major systems of interest. We will present our recent work on computational modeling and simulations of their function, including an overview of their critical interactions with phospholipids and small molecules, their mechanism of action, and potential drug candidates that may alter their function towards either enhancing or suppressing ferroptosis.

28