BPS Program Book 2014

2830-P os B oard #B522 BIOPHYSICAL PROPERTIES OF CX40 MUTANTS LINKED TO ATRIAL FIBRILLATION. Virgis Valiunas , Ana Santa Cruz, Laima Valiuniene, Gulistan Mese, Thomas W. White, Peter R. Brink 2831-P os B oard #B523 international travel awardee THE MITOCHONDRIAL PERMEABILITY TRANSITION IN SACCHAROMYCES CEREVISIAE IS CONTROLLED BY HEXOSE PHOSPHATES FROM THE GLYCOLYTIC PATHWAY. Monica Rosas-Lemus , Natalia Chiquete-Felix, Salvador Uribe-Carvajal 2832-P os B oard #B524 ANO1 - A CANDIDATE FOR ANGIOTENSIN-II-ACTIVATED CALCIUM DEPENDENT CHLORIDE CHANNEL IN HUMAN ATRIAL FIBROBLASTS. Antoun El Chemaly, Caroline Norez, Christophe Magaud, Aurelien Chatelier, Patrick Bois 2833-P os B oard #B525 EMERGING ELECTROPHYSIOLOGY OF FACULTATIVE BACTERIAL PATHOGENS. Ian Rowe , Vladislav Belyy, Andriy Anishkin, Herman Sintim, Anwar Huq, Sergei Sukharev 2834-P os B oard #B526 THE COUPLING OF TENSION AND CROWDING SENSING IN THE BACTERIAL CHANNEL MSCS. Andriy Anishkin, Ian Rowe, Sergei Sukharev  Cardiac Muscle II (Boards #B527–#B558) 2835-P os B oard #B527 THERMAL ACTIVATION OF CARDIAC THIN FILAMENTS INDUCES CONTRACTION WITHOUT INTRACELLULAR CA 2+ CHANGES: STUDIES WITH CARDIOMYOCYTES AND AN IN VITRO MOTILITY ASSAY. Kotaro Oyama , Shuya Ishii, Tomomi Arai, Seine A. Shintani, Hideki Itoh, Norio Fukuda, Madoka Suzuki, Shin’ichi Ishiwata 2836-P os B oard #B528 FASTER CROSS-BRIDGE RELAXATION RATES CORRELATE WITH INCREASED TENSION COST IN HCM WITH THE R403Q MYH7 MUTATION. Rosalie Witjas-Paalberends, Claudia Ferrara, Beatrice Scellini, Judith Montag, Ger Stienen, Theresia Kraft, Michelle Michels, Carolyn Ho, Corrado Poggesi, Jolanda van der Velden 2837-P os B oard #B529 THE R403Q MUTATION ALTERS ISOMETRIC AND ENERGETIC PROPERTIES IN 2 MONTH MICE. Camille Birch , John Konhilas 2838-P os B oard #B530 THE HCM MUTATION R453C IN THE HUMAN BETA MYOSIN MOTOR DOMAIN ALTERS THE ATP-BINDING AND HYDROLYSIS STEPS. Marieke Bloemink, John Deacon, Stephen Langer, Carlos Vera, Ariana Combs, Leslie Leinwand, Michael A. Geeves 2839-P os B oard #B531 SPECTROSCOPIC SYSTEM FOR CHARACTERIZATION OF HUMAN β -CARDIAC MYOSIN. Anja M. Swenson , Donald A. Winkelmann, Christopher M. Yengo 2840-P os B oard #B532 DIFFERENCES IN ACTIVATION AND RELAXATION KINETICS OF HUMAN FETAL SKELETAL AND CARDIAC MYOFIBRILS. Alice Ward Racca , Anita E. Beck, Michael J. Bamshad, Michael Regnier

2841-P os B oard #B533 IMPROVED LOADED IN VITRO MOTILITY ASSAY AND ACTIN FILAMENT TRACKING SOFTWARE DELINEATES THE EFFECT OF HYPERTROPHIC AND DILATED CARDIOMYOPATHY MUTATIONS ON THE POWER OUTPUT OF CARDIAC MYOSIN. Tural Aksel , Masataka Kawana, Arjun Adhikari, Shirley Sutton, Kathleen Ruppel, James Spudich 2842-P os B oard #B534 MODULATION OF THE CARDIAC SARCOMERE BY A SMALL MOLECULE AGENT MYK0000461: A POTENTIAL THERAPEUTIC FOR THE TREATMENT OF GENETIC HYPERTROPHIC CARDIOMYOPATHIES. Hector M. Rodriguez , Stephanie Whitman-Cox, Raja Kawas, Yonghong Song, Arvinder Sran, Johan Oslob 2843-P os B oard #B535 BIOPHYSICAL ANALYSIS OF THE PUTATIVE HEART FAILURE DRUG OMECAMTIV MECARBIL. Joseph M. Muretta , Ewa Prochniewicz, David D. Thomas 2844-P os B oard #B536 IMPACT OF REGULATORY LIGHT CHAIN PHOSPHORYLATION ON THE STIFFNESS OF α AND β MYOSIN. Gerrie P. Farman, Jeffery R. Moore 2845-P os B oard #B537 THE EFFECT OF MYOSIN REGULATORY LIGHT CHAIN PHOSPHORYLATION ON N47K MUTANT MYOSINMECHANICS. Anastasia Karabina , Priya Muthu, Katarzyna Kazmierczak, Danuta Szczesna-Cordary, Jeffrey Moore 2846-P os B oard #B538 VENTRICULAR MYOSINMODIFIES IN VITRO STEP-SIZEWHEN PHOSPHORYLATED. YihuaWang , Katalin Ajtai, Thomas P. Burghardt 2847-P os B oard #B539 A13T MUTATION IN THE REGULATORY LIGHT CHAIN ASSOCIATED WITH CARDIAC HYPERTROPHY IMPOSES DIFFERENCES IN KINETICS OF HEALTHY AND DISEASED VENTRICLES. Janhavi Nagwekar , Divya Duggal, Krishna Midde, Priya Muthu, W Huang, Rafal Fudala, Ignacy Gryczynski, Zygmunt Gryczynski, Danuta Szczesna-Cordary, Julian Borejdo 2848-P os B oard #B540 THE K104E MUTATION OF THE MYOSIN REGULATORY LIGHT CHAIN ALTERS KINETICS AND DISTRIBUTION OF ORIENTATIONS OF CROSS-BRIDGES IN TRANSGENIC CARDIAC MYOFIBRILS. Divya Duggal , Janhavi Nagwekar, Ryan Rich, W Huang, Krishna Midde, Rafal Fudala, Ignacy Gryczynski, D Szczesna-Cordary, Julian Borejdo 2849-P os B oard #B541 MEASURING WORK LOOPS IN INTACT ISOLATED CARDIAC MYOCYTES BY CONTROLLING PRE- AND AFTERLOAD USING A NEW GENERATION FORCE TRANSDUCER. Michiel Helmes , Ernst J. Breel, Davide Iannuzzi, Jolanda van der Velden 2850-P os B oard #B542 TEMPERATURE AND TRANSMURAL REGION INFLUENCE FUNCTIONAL MEASUREMENTS IN UNLOADED LEFT VENTRICULAR CARDIOMYOCYTES. Charles S. Chung , Kenneth S. Campbell 2851-P os B oard #B543 A NOVEL METHOD FOR ISOLATING AND CULTURING HUMAN CARDIOMYOCYTES FROMCRYOPRESERVED TISSUES. Carmine Gentile , Bernard Kuehn, Michael J. Davies, Cristobal G. dos Remedios

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Biophysical Society 58 th Annual Meeting, San Francisco, California