BPS Program Book 2014

147-P lat 11:30 am STRUCTURAL BASIS OF CONFORMATIONAL TRANSITIONS INVOLVED IN PSEUDOPILUS ASSEMBLY AND STABILITY. Michael Nilges , Mangayarkarasi Nivaskumar, Guillaume Bouvier, Manuel Campos, Edward H. Egelman, Xiong Yu, Olivera Francetic 148-P lat 11:45 am A SINGLE INTER-DOMAIN SALT BRIDGE WITHIN THE HUMAN ARGONAUTE 2 PROTEIN CRUCIALLY AFFECTS PROTEIN FOLDING AND CONSEQUENTLY ENZYMATIC ACTIVITY. Munishikha Kalia , Sarah Willkomm, Jens Christian Claussen, Alexandre M.J.J. Bonvin, Tobias Restle 149-P lat 12:00 pm MECHANISMS OF SUBSTRATE DEGRADATION BY ENERGY- DEPENDENT PROTEASES. Andreas Martin , Mary Matyskiela, Kristofor Nyquist, Gabriel Lander, Robyn Beckwith, Eric Estrin, EvanWorden 150-P lat 12:15 pm STRUCTURE, DYNAMICS, EVOLUTION AND FUNCTION OF A MAJOR SCAFFOLD COMPONENT IN THE NUCLEAR PORE COMPLEX. Seung Joong Kim , Parthasarathy Sampathkumar, Paula Upla, William Rice, Jeremy Phillips, Benjamin Timney, Javier Fernandez-Martinez, Andrej Sali, Michael Rout, Steven Almo 151-P lat 12:30 pm STRUCTURAL GYMNASTICS BY PROTEINS MAKE THE CLOCK MECHANISM GO ROUND AND ROUND. Yong-Gang Chang, Roger Tseng, William K. Myers, Jonathan Kerby, David Britt, Andy LiWang 10:45 am –12:45 pm , R oom 303 Platform Bioenergetic Processes in Bacteria, Chloroplasts, and Mitochondria Co-Chairs Gabriela Schlau-Cohen, Stanford University Wang Wang, University of Washington 152-P lat 10:45 am SINGLE-MOLECULE LIVE-CELL IMAGING OF BACTERIAL RESPIRATORY COMPLEXES INDICATES OXPHOS DELOCALIZATION. Mark Leake 153-P lat 11:00 am CARDIOLIPINS AT THE INTERFACE OF SUPERCOMPLEXES IN THE RESPIRATORY CHAIN. Clement Arnarez , Siewert-Jan Marrink, Xavier Periole 154-P lat 11:15 am ELUCIDATION OF THE PHOTODYNAMICS OF SINGLE PHOTOSYNTHETIC LH2 COMPLEXES IN SOLUTION. Gabriela S. Schlau-Cohen , Quan Wang, June Southall, Richard J. Cogdell, W.E. Moerner 155-P lat 11:30 am MECHANISM OF WATER SPLITTING BY PHOTOSYSTEM II. Yulia Pushkar , Katherine Davis, Lifen Yan 156-P lat 11:45 am STRUCTURAL COUPLING OF THE EF HAND AND C-TERMINAL GTPASE DOMAINS IN THE MITOCHONDRIAL PROTEIN MIRO. Julian Klosowiak , Pamela Focia, Srinivas Chakravarthy, Eric Landahl, Douglas Freymann, Sarah Rice

157-P lat 12:00 pm INTERACTION OF THE BAK HOMODIMER WITH THE MEMBRANE. Sreevidya Aluvila, Tirtha Mandal, Kyoung Joon Oh 158-P lat 12:15 pm FISSION PROMOTES RESPIRATION AND ROS PRODUCTION IN INDIVIDUAL MITOCHONDRIA. Huiliang Zhang , Shey-Shing Sheu, Wang Wang 159-P lat 12:30 pm THE CORRELATION BETWEEN UCP EXPRESSION UND CELLULAR METABOLISM. Anne Rupprecht , Dana Sittner, Alina Smorodchenko, Karolina E. Hilse, Rudolf Moldzio, Andrea E. M. Seiler, Anja U. Bräuer, Elena E. Pohl Co-Chairs Andrew Plested, Leibniz-Institut für Molekulare Pharmakologie (FMP), Germany Ehud Isacoff, University of California, Berkeley 160-P lat 10:45 am ENERGETIC COUPLING OF THE LIGAND BINDING DOMAIN TO PORE OPENING IN NMDA RECEPTORS. Rashek Kazi , Jian Dai, Melissa Daniel, Huan-Xiang Zhou, Lonnie P. Wollmuth 161-P lat 11:00 am REGULATORY IONS BOUND AT THE IGLUR LIGAND BINDING DOMAIN DIMER INTERFACE - A SHARED PROPERTY OF GLUK2 AND AVGLUR1? Maria Musgaard , Jack Barber, M. Khadeesh bin Imtiaz, Philip C. Biggin 162-P lat 11:15 am NMDA AND AMPA RECEPTOR LIGAND-BINDING DOMAINS EXHIBIT SUBTYPE-SPECIFIC CONFORMATIONAL PROPENSITIES. John Belcher, Yongneng Yao, Anthony Berger, Mark L. Mayer, Albert Y. Lau 163-P lat 11:30 am PROBING THE CHANNEL GATING OF A GLUTAMATE RECEPTOR WITH A PHOTOACTIVE UNNATURAL AMINO ACID. Viktoria Klippenstein , Andrew J. Plested 164-P lat 11:45 am ACTIVATION OF LIGAND BINDING DOMAINS OF AN AMPA-TYPE GLUTAMATE RECEPTOR. Jelena Baranovic , Miriam Chebli, Hector P. Salazar, Katja Faelber, Valentina Ghisi, Albert Y. Lau, Oliver Daumke, Andrew J R Plested 165-P lat 12:00 pm PROBING THE GATING OF IONOTROPIC GLUTAMATE RECEPTORS WITH TETHERED PHOTOSWITCHABLE LIGANDS. Andreas Reiner , Ehud Y. Isacoff 166-P lat 12:15 pm OCCUPANCY OF A SINGLE BINDING SITE IS SUFFICIENT FOR AMPAR ACTIVATION. Indrani Bhattacharyya , Rikard Blunck 167-P lat 12:30 pm IMAGED BY CRYO-EM, ACTIVATED AND DESENSITIZED GLUA2 GLUTAMATE RECEPTORS SHOW EXTREME FLEXIBILITY. Hideki Shigematsu , Youshan Yang, Yangyang Yan, Katharina Duerr, Eric Gouaux, Fred J. Sigworth 10:45 am –12:45 pm , R oom 304 Platform Ligand-gated Channels I

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Biophysical Society 58 th Annual Meeting, San Francisco, California