BPS Program Book 2014

3763-P os B oard #B491 ELECTROSTATIC INTERACTIONS IN THE CLOSED AND OPEN STATES OF VOLTAGE-GATED PROTON CHANNELS. Feng Qiu , Adam Chamberlin, Sergei Noskov, H. Peter Larsson 3764-P os B oard #B492 ON THE LOCATION OF BINDING SITES OF 2-GUANIDINOBENZIMIDAZOLE IN THE VOLTAGE-GATED PROTON CHANNEL. Adam C. Chamberlin , Feng Qui, Sergei Noskov, Peter Larsson 3765-P os B oard #B493 INHIBITION OF VOLTAGE-GATED HV1 CHANNEL BY GUANIDINE DERIVATIVES. Liang Hong , Iris Kim, Francesco Tombola 3766-P os B oard #B494 EXPLORING CONFORMATIONAL REARRANGEMENTS IN A NOVEL VOLTAGE-SENSING PROTEIN. Ferenc Papp , Erika Babikow, Jaime Smith, Tsg-Hui Chang, Kenton J. Swartz 3767-P os B oard #B495 THE RESTING STATE OF HUMAN PROTON CHANNEL FROM FUNCTIONAL AND STRUCTURAL DETERMINATIONS. Qufei Li , Sherry Wanderling, Eduardo Perozo 3768-P os B oard #B496 ELECTROMECHANICAL COUPLING IN GATING OF THE HV1 VOLTAGE SENSOR IS REVEALED BY RESTING-STATE CURRENTS IN AN S4 ARG TO HIS MUTATION (R205H). I. Scott Ramsey , Aaron L. Randolph 3769-P os B oard #B497 LONG ALPHA-HELICES PROJECTING FROM THE MEMBRANE AS THE DIMER INTERFACE IN THE VOLTAGE-GATED H + CHANNEL. Yuichiro Fujiwara , Tatsuki Kurokawa, Yasushi Okamura 3770-P os B oard #B498 PH SENSITIVITY OF VOLTAGE SENSING DOMAIN RELAXATION. Carlos A. Villalba-Galea 3771-P os B oard #B499 GATING-COUPLED CLUSTERING-DISPERSION DYNAMICS OF THE KCSA POTASSIUM CHANNEL IN A LIPID MEMBRANE. Ayumi Sumino , Daisuke Yamamoto, Masayuki Iwamoto, Takehisa Dewa, Shigetoshi Oiki 3772-P os B oard #B500 TOWARDS THE INCORPORATION OF FUNCTIONAL ION CHANNEL PROTEINS IN TETHERED MEMBRANES. David P. Hoogerheide , Amit Vaish, Tatiana Rostovtseva, Adam Kuszak, Sergey Bezrukov, Susan Krueger, Hirsh Nanda 3773-P os B oard #B501 A NOVEL MECHANISM OF VOLTAGE SENSING AND GATING IN K2P POTASSIUM CHANNELS. Marcus Schewe , Markus Rapedius, Ehsan Nematian-Ardestani, Thomas Linke, Klaus Benndorf, Stephen J. Tucker, Thomas Baukrowitz 3774-P os B oard #B502 SHIFTING THE GATING EQUILIBRIUM OF A POTASSIUM CHANNEL VIA HYDROPHOBIC MISMATCH. Dylan O. Burdette , Adrian Gross 3775-P os B oard #B503 CORRELATED SINGLE-MOLECULE SPECTROSCOPY AND PATCH-CLAMP STUDIES OF VOLTAGE GATED ION CHANNEL ACTIVATION DYNAMICS IN LIVING CELLS. Dibyendu Sasmal, H. Peter Lu

3750-P os B oard #B478 PROBING MECHANISMS THROUGH WHICH DRUGS AFFECT VOLTAGE-SENSITIVE GATING. Zachary Beller , Mark Zaydman, Jianmin Cui 3751-P os B oard #B479 SINGLE MOLECULE FLUORESCENCE OF AN S4-BASED VOLTAGE SENSOR. Jeremy S. Treger , Michael F. Priest, Tomoya Kubota, Ludivine Frezza, Francisco Bezanilla 3752-P os B oard #B480 EFFECTS OF DECREASED HYDROPHOBICITY ABOVE R1 IN S4-BASED VOLTAGE SENSORS. João L. Carvalho-de-Souza , Jerome J. Lacroix, Francisco Bezanilla 3753-P os B oard #B481 GENETICALLY-ENCODED FLUORESCENT VOLTAGE SENSORS CAPABLE OF RESOLVING A 6MV DEPOLARIZATION. Arong Jung 3754-P os B oard #B482 THE EFFECT OF INTERHELICAL LOOP LENGTH AND COMPOSITION ON THE ELECTROSTATIC INTERACTIONS DIRECT EVIDENCE OF CONFORMATIONAL CHANGES ASSOCIATED WITH VOLTAGE-GATING IN A VOLTAGE SENSOR PROTEIN BY TIME-RESOLVED X-RAY/NEUTRON INTERFEROMETRY. J. K. Blasie , A Tronin, J W. Strzalka, I Kuzmenko, D Worcester, V Lauter, J A. Freites, D J. Tobias 3756-P os B oard #B484 NETWORKS OF COEVOLVING RESIDUES IN VOLTAGE SENSOR DOMAINS. Vincenzo Carnevale , Eugene Palovcak, Lucie Delemotte, Michael Klein 3757-P os B oard #B485 A STRUCTURE BASED COURSE-GRAINING PHYSICAL MODELING OF THE VOLTAGE ACTIVATED KV1.2 CHANNEL - SIMULATING AND ANALYZING THE FAST GATING CURRENT. Ilsoo Kim , Arieh Warshel 3758-P os B oard #B486 ROLE OF CHARGED RESIDUES IN THE REGULATION OF VOLTAGE SENSOR MOVEMENT IN HERG K + CHANNELS. Yue Wu , Ying Dou, David Fedida 3759-P os B oard #B487 THE N-TERMINUS OF AUXILIARY BETA SUBUNIT IS INVOLVED IN THE MODULATION OF VOLTAGE SENSOR BK PORE-FORMING ALPHA SUBUNIT. Karen Castillo 3760-P os B oard #B488 WHOLE-CELL GATING-CHARGE MEASUREMENTS FOR ANALYSIS OF ALLOSTERIC DOMAIN COUPLING IN HSLO1 BK CHANNELS. Guido Gessner , Katharina Held, Toshinori Hoshi, Stefan H. Heinemann 3761-P os B oard #B489 PROBING THE VOLTAGE GATED PROTON CHANNEL HV1 WITH FRET. Victor De la Rosa , Gisela E. Rangel-Yescas, Ernesto Ladron-de-Guevara, Leon D. Islas 3762-P os B oard #B490 THE ACTIVATION KINETICS OF THE VOLTAGE-GATED PROTON CHANNEL IS DRASTICALLY ACCELERATED BY UNSATURATED FATTY ACIDS. Akira Kawanabe , Yasushi Okamura OF THE VOLTAGE SENSOR DOMAIN OF JSHAK1. Nazlee Sharmin, Matthias Ostermaier, Warren J. Gallin 3755-P os B oard #B483

194

Biophysical Society 58 th Annual Meeting, San Francisco, California