BPS Program Book 2014

measurement positions has never been more intuitive. Details of several different applications of FluidFM in cell biology will be presented including pick and place of single cells, single cell force spectroscopy, cellular injection and micropatterning under liquids. Presenters: Marko Loparic , Research Associate, Biozentrum and the Swiss Nanoscience Institute, University of Basel Saju Nettikadan, General Manager, Nanosurf, Inc. 3:30 pm –4:30 pm , R oom 122 Early Careers Committee Meeting 4:00 pm –5:00 pm , R oom 300 Career Center Workshop Ten Tough Industrial Interview Questions (and Ten Pretty Good Responses) You’ve been invited to interview with that drug development company that you’ve always wanted to work for. You’ve soaked up the details of the position description. You are confident in your ability to do the job, as well as answer any/all technical questions during the interview pro- cess. The day is yours…until…that first question catches you by surprise and your confidence begins to wilt. Be prepared for those non-technical questions that you will almost certainly hear at some point, know why they are asked, and learn what a good (if not great) response to each question might be by attending this workshop. 4:00 pm –6:00 pm , R oom 134 Symposium Cellular Stress, Protein Folding, and Disease Co-Chairs Judy Kim, University of California, San Diego Conner Sandefur, University of North Carolina at Chapel Hill 184-S ymp 4:00 pm SPECTROSCOPIC STUDIES OF MEMBRANE PROTEIN FOLDING: CHANGES IN HYDRATION. Judy Kim 185-S ymp 4:30 pm PROTEIN INTERACTIONS AND TRANSITION TIMES THAT INFLUENCE THE PATHOGENESIS OF PROTEIN FOLDING DISEASES. Santiago Schnell 186-S ymp 5:00 pm POST-TRANSLATIONAL MODIFICATIONS PROMOTE FORMATION OF SOD1 OLIGOMERS WITH POTENTIAL TOXICITY IN ALS. Nikolay V. Dokholyan, Rachel L. Redler, Elizabeth A. Proctor, Feng V. Ding, Kyle Wilcox, Michael Caplow 187-S ymp 5:30 pm CELL STRESS AND PROTEOSTASIS NETWORKS IN BIOLOGY, AGING, AND DISEASE. Richard Morimoto 4:00 pm –6:00 pm , R oom 135 Symposium Celebrating 100 Years of Crystallography: X-Rays Are Photons Too Co-Chairs Gregory Petsko, Brandeis University Jane Richardson, Duke University 188-S ymp 4:00 pm CRYSTALLOGRAPHY–ENERGETICALLY INNOVATIVE AT 100. Jane S. Richardson

activities. The 2013 wiki-edit contest winners will also be introduced at the session. Register your username, do an edit, and get a WikiProject Biophysics button to wear! Speakers: Daniel Mietchen,WikiProject Open Access and Museum für Naturkunde, Berlin (User: Daniel Mietchen) Jane Richardson, Duke University, BPS Past President and addicted wiki editor (User: Dcrjsr) 2:30 pm –3:30 pm , R oom 300 Career Center Workshop Networking Now: How to Maximize Success at BPS 2014 You have probably heard that you have to network, network, network to find a job or jump start your career. Meetings and conferences such as BPS 2014 provide many opportunities to network, but capitalizing on these opportunities can sometimes be a challenge. This highly interactive session will provide networking tips, techniques, strategies and practice to meet that challenge and ensure your success. 2:30 pm –4:00 pm , R oom 301 Funding If Not from Federal Agencies, from Where? Come hear experts representing foundations, nonprofits, universi- ties, and business discuss non-federal sources of research funding, how to pursue them, and whether they present a viable substitute for decreased government funding sources. The panelists will also discuss if and how their funding strategies have changed in response to federal funding, how scientists can effectively forge relationships with industry and foundations, and how universities are responding to the chang- ing funding landscape. This session is sponsored by the Public Affairs Committee. Speakers: Robert Conn, President, The Kavli Foundation Bill Balke, University of California, San Francisco, and American Heart Association Mark Adams, Scientific Director, J. Craig Venter Institute 3:00 pm –4:30 pm , R oom 123 Exhibitor Presentation Nanosurf, Inc. Development of Automation and Nanofluidics to Extend Applications of Atomic Force Microscopy In an effort to extend the range of atomic force microscope (AFM) applications, we have developed automation routines for nanomechanical analysis of large un- even samples and incorporated nanofluidics for nanomanipulation experiments. We will present details of a method that has been developed to compensate for the Z-range limitation and to automate the data collection over large sample areas. To compensate for large surface corrugations on biologically relevant sam- ples, customized hardware and software algorithms for automated leveling have been developed and implemented. This method consists of a patented vertical alignment system, which is activated whenever the Z piezo reaches its limit (i.e., max. extension or max. retraction). This method allows for AFM investigation to proceed uninterrupted and error-free over corrugated surfaces. FluidFM combines the positional accuracy and force sensitivity of AFM with the unique possibilities of nanofluidics to provide a whole new level of control and possibilities in nanomanipulations and analysis. The FluidFM system includes a fully integrated AFM, pressure controller and hollow microfabricated cantilevers. The integrative nature of its touchscreen-based control software brings together optical, force, pressure, and position control in one place. The entire system is easy to use and allows objects and experimental settings to be manipulated via on-screen interactions. Moving a sample or indicating

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Biophysical Society 58 th Annual Meeting, San Francisco, California

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