BPS2024 Full Program & Abstracts

2949 -Pos Travel Award Winner CLUSTER FORMATION BETWEEN BK AND CA V 1.3 CHANNELS PRECEDES THEIR INSERTION INTO THE PLASMA MEMBRANE. Roya Pournejati , Claudia M. Moreno, Oscar Vivas Ligand-Gated Channels II (Boards B342 - B359) 2950-Pos Board B342 GLUN2 SUBUNITS DICTATE NMDAR CONFORMATIONAL TRAJECTO RIES. Julia Bleier , Cherise Stanley, Chris Habrian, Ehud Y. Isacoff 2951-Pos Board B343 Travel Award Winner INVESTIGATING THE ROLE OF GLUN1 MET813 ON NMDA RECEPTOR GATING. Faye D. Raymond , Lynn M. Ziegler, Jamie A. Abbott, Gabriela K. Popescu 2952-Pos Board B344 PROBING THE MEMBRANE-ACCESS PATHWAY OF NMDA RECEPTORS WITH KETAMINE ENANTIOMERS. Jamie A. Abbott , Beiying Liu, Gabriela K. Popescu 2953-Pos Board B345 ALLOSTERIC MODULATION OF SUBUNIT-SPECIFIC CONFORMATIONAL AND FUNCTIONAL DIFFERENCES IN NMDA RECEPTORS. Paula A. Bender , Ryan J. Durham, Subhajit Chakraborty, Elisa Carillo, Vladmir Berka, Vasanthi Jayaraman 2954-Pos Board B346 Travel Award Winner ELUCIDATING THE GATING MECHANISMS OF DISEASE-RELATED GLUN1 Y647 VARIANTS. Samantha R. Schwarz , Jamie A. Abbott, Gabriela K. Popescu 2955-Pos Board B347 REGULATION OF GLUA2-AMPA SUBTYPE IGLURS BY AUXILIARY PRO TEINS TARP-Γ5 AND CNIH2. Maria V. Yelshanskaya, Laura Yen, Shanti P. Gangwar , Alexander I. Sobolevsky 2956-Pos Board B348 RECURRENT SWITCHING OF LIGAND RECOGNITION IN THE IGLUR SU PERFAMILY. Yuhong Wang , Timothy Lynagh 2957-Pos Board B349 Travel Award Winner DYNAMIC CALCIUM SELECTIVITY OF NMDA RECEPTORS IS CONTROLLED BY THE AMINO-TERMINAL DOMAIN. Mae G. Weaver , Gabriela K. Popescu 2958-Pos Board B350 CONFORMATIONAL DYNAMICS DURING PARTIAL AGONISM OF HETERO MERIC GLUK2/K5 KAINATE RECEPTOR. Anindita Das , Nabina Paudyal, Elisa Carrillo, Vladmir Berka, Vasanthi Jayaraman 2959-Pos Board B351 IDENTIFYING STRUCTURAL DETERMINANTS IN CALMODULIN-DEPEN DENT INHIBITION OF NMDA RECEPTORS. Gary J. Iacobucci , Hannah Premo, Beiying Liu, Gabriela K. Popescu 2960-Pos Board B352 HOW WE SENSE GLUTAMATE: ALLOSTERIC REGULATION OF AMPA RECEPTORS. Edward C. Twomey 2961-Pos Board B353 STRUCTURAL INVESTIGATIONS OF P2X2 RECEPTOR CHANNELS. Surbhi Dhingra , Kenton Swartz 2962-Pos Board B354 CHARACTERIZATION OF ASIC COMPOSITION IN HUMAN SENSORY NEU RONS. Victoria Jiang , Nien-Du Yang, Bryan D. Moyer, John M. Gilchrist Board B341

2963-Pos Board B355 ENGINEERED CHLORIDE-CONDUCTING CHANNELS IN UROTHELIAL CELLS FOR POTENTIAL TREATMENT OF INTERSTITIAL CYSTITIS. Qiang Chen , Aparna Nigam, Tommy S. Tillman, Joel Caporoso, Lingling Jiang, Jonathan M. Beckel, Jon W. Johnson, Pei Tang, Yan Xu 2964-Pos Board B356 LIGAND BINDING TO RESTING PACEMAKER CHANNELS IS COOPERATIVE IN NATIVE MEMBRANES. Stefan Kuschke, Susanne Thon, Tina Schwabe, Christian Sattler, Klaus Benndorf, Ralf Schmauder 2965-Pos Board B357 GATING MECHANISM OF ESCHERICHIA COLI’S ONLY POTASSIUM CHAN NEL. Brian Morote Costas , Lie Wang, Yaping Pan, Steve W. Lockless, Ming Zhou 2966-Pos Board B358 SCREENING FOR HOMO- AND HETERODIMER FORMATION OF TMEM16/ ANOCTAMIN FAMILY MEMBERS BY NATIVE POLYACRYALMIDE GEL ELECTROPHORESIS. Linlu Li , Runan Yang, Shangdong Liang, Günther Schmalzing 2967-Pos Board B359 STRUCTURE AND FUNCTION OF AN ATP-SENSING CHANNEL FROM MY COBACTERIA. Alexandre G. Vouga, Michael E. Rockman, Lisandra Flores Aldama, Jesus Blazquez, Sebastian E. Brauchi, Brad S. Rothberg Ion Channels, Pharmacology, and Disease II (Boards B360 - B382) 2968-Pos Board B360 MODELING TOXIN EFFECTS ON SODIUM CHANNELS IN NEURONS USING REAL-TIME DYNAMIC CLAMP. Brian K. Panama , Shivani Archarya, Rafael V. Ortiz, Cameron M. Bass, Leigh Korbel, Randall L. Rasmusson, Glenna Bett, Mark W. Nowak 2969-Pos Board B361 EXPRESSION OF MODEL ION CHANNEL CURRENTS GENERATED US ING NEURON IN SILICO SOFTWARE IN REAL TIME USING DYNAMIC CLAMP. Shivani Acharya, Brian K. Panama, Leigh Korbel, Lars Nilsson, Michael L. Hines, Nicholas T. Carnevale, Glenna C.L. Bett, Randall L. Rasmusson, Mark W. Nowak 2970-Pos Board B362 PREDICTED DRUG EFFECTS ON THE ACTION POTENTIAL VARY SIGNIFI CANTLY WITH DIFFERENT MODELS. Hui Jia Farm , Michael Clerx, Fergus Cooper, Liudmila Polonchuk, Ken Wang, David Gavaghan, Chon Lok Lei 2971-Pos Board B363 ELUCIDATING THE STRUCTURAL AND FUNCTIONAL UNIQUENESS OF MULTI-CHARACTERISTIC OPSIN, A HIGHLY BIOENGINEERED, AMBIENT LIGHT SENSITIVE MOLECULE, WITH BROADBAND SPECTRAL RESPON SIVENESS AND FAST KINETICS TO MODULATE NEURAL ACTIVITIES. Praty ajit Mohapatra , Amir Singh, William Marks, Michael Carlson, Subrata Batabyal, Samarendra K. Mohanty 2972-Pos Board B364 CATEGORIZING TDP RISK WITH THE QNET METRIC SCORE (TMS) USING A TWO STEP ACTIVATION PROTOCOL. Brian K. Panama, Mark W. Nowak, Shivani Acharya, Rafael V. Ortiz, Glenna C.L. Bett, Randall L. Rasmusson, Leigh Korbel 2973-Pos Board B365 ACUTE FLECAINIDE TOXCICITY IS PROMOTED BY HYPONATREMIA, AND CAN BE ALLEVIATED BY NORMALIZING NA LEVELS. William P. Adams , Gregory Hoeker, Steven Poelzing, Biwar Z. Marof

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