BPS2025 Full Program

Platform Voltage-Gated K Channels I 8:15 am - 10:15 am, Room 502B

Platform Biophysics Education 8:15 am - 10:15 am, Room 501ABC

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Co-Chairs Jianhan Chen, University of Massachusetts, USA Nina Ottosson, Linköping University, Sweden 1639-Plat 8:15 am HYDROPHOBIC GATING OF ION CHANNELS. ZhiGuang Jia, Jianhan Chen 1640-Plat 8:30 am BIOPHYSICAL PROPERTIES OF BK CHANNELOPATHIES IN HETEROZYGOUS CONDITIONS. Xiaoan Wu , Yanyan Geng, Alice Butler, Lawrence Salkoff, Karl L. Magleby 1641-Plat 8:45 am CO-ASSEMBLY OF BETA2 AND BETA3A SUBUNITS IN BK CHANNEL. Yu Zhou , Xiaoming Xia, Gopal Kallure, Sandipan Chowdhury, Chris Lingle 1642-Plat 9:00 am CARDIOTOXIC EFFECTS OF SYNTHETIC CANNABINOID RECEPTOR AGO NISTS: INHIBITION OF HERG AND KV7.1/KCNE1 CHANNELS WITH PRO POSED HERG BINDING SITE. Damon J.A. Frampton, Tanadet Pipatpolkai, Akshay Sridhar, Maryke Venter, Amaia Jauregi Miguel, Henrik Green, Nina E. Ottosson , Sara I. Liin 1643-Plat 9:15 am PIP2 AND CA2+-CALMODULIN ALLOSTERICALLY REGULATE THE INAC TIVATION OF THE VOLTAGE-DEPENDENT POTASSIUM CHANNEL KV7.1. Nitzan Daus, Flavio Costa, Carlo Guardiani, Maya Lipinsky, Ariel Ben Bassat, Yoni Haitin, Alberto Giacomello, Bernard Attali 1644-Plat 9:30 am STRUCTURAL INVESTIGATION OF AN INTERMEDIATE STATE OF KCNQ1. Efthymios Kyriakis , Daniel Sastre Martinez, Jodene R. Eldstrom, Sophia Russo, Fariba Ataei, Ying Dou, Magnus Chan, Steven Molinarolo, Filip Van Petegem, David Fedida 1645-Plat 9:45 am DEVELOPMENTAL ENCEPHALOPATHY-ASSOCIATED MUTATIONS CAUSE CONSTITUTIVE OPENING OF THE KV7.2 CHANNEL INNER PORE GATE. Agnese Roscioni , Mario Nappi, Giulio Alberini, Alessandro Berselli, Maria Virginia Soldovieri, Vincenzo Barrese, Sarah Weckhuysen, Ingrid Scheffer, Francesco Miceli, Fabio Benfenati, Luca Maragliano, Maurizio Taglialatela 1646-FlashTalk 10:00 am THE EFFECTS OF LONG QT SYNDROME ASSOCIATED MUTATION R231C ON THE CARDIAC IKS CHANNEL. Yahnell Judah , Xiaoan Wu, Marta E. Perez, Peter H. Larsson 1647-FlashTalk 10:05 am INFLUENCE OF THE S2S3 LOOP AND CALMODULIN ON THE VOLTAGE SENSOR MOVEMENT AND GATE OPENING IN KV7 CHANNELS. Sara Alicante Martinez , Eider Nuñez, Arantza Muguruza Montero, Marta E. Perez, Maykelis Diaz Solares, Rene Barro-Soria, Alvaro Villarroel 1648-FlashTalk 10:10 am ELECTROPHYSIOLOGICAL AND STRUCTURAL CHARACTERIZATION OF THE BINDING OF THE CARDIAC ION CHANNEL BLOCKER UCL2077 TO KCNQ1 CHANNELS. Daniel Sastre , Efthymios Kyriakis, Julia Schauer, Magnus Chan, Ying Dou, Jodene R. Eldstrom, Filip Van Petegem, David Fedida

Co-Chairs Julia Koeppe, State University New York (SUNY), Oswego, USA Suraj Mishra, Allen Institute, USA 1649-Plat 8:15 am ENGINEERING BIOLOGY PROBLEMS BOOK. Ilya D. Klabukov , Denis Baranovskii, Anna Yakimova, Peter Shegai, Andrey D. Kaprin 1650-Plat 8:30 am Canceled COMPUTATIONAL CHEMISTRY IN THE CLASSROOM: INTRODUCING MOLECULAR DYNAMICS SIMULATIONS AT THE UNDERGRADUATE LEVEL. Jessica Sarver 1651-Plat 8:45 am CODING FOR CANCER: A VIRTUAL OUTREACH PROGRAM AIMED AT INCREASING YOUTH INTEREST IN CANCER RESEARCH AND COMPUTA TIONAL BIOLOGY. Matthew C. Chan , Katherine Brower, Hanako Osuga, Jeanne T. Chowning 1652-Plat 9:00 am LABORATORY EXPERIMENTS TO MEASURE THE EFFECT OF THE SICKLE CELL TREATMENT VOXELOTOR ON METHEMOGLOBIN AGGREGATION. Rachael Barry , Aaron Amin, Aldo J. Munoz, Steven Mang, Melanie J. Cocco 1653-Plat 9:15 am USING PROTEIN STRUCTURE TO PREDICT FUNCTION IN UNDERGRADU ATE BIOCHEMISTRY. Julia R. Koeppe 1654-Plat 9:30 am BUILDING EXPLANATORY MODELS OF LIGAND-RECEPTOR INTERAC TIONS IN AN ADVANCED UNDERGRADUATE NEUROPHARMACOLOGY CLASS. Macy Parmelee, Anna Engelke, Bryant Hutson, Rachel Penton 1655-Plat 9:45 am FROM THE GROUND UP: BUILDING A PEER MENTORSHIP PROGRAM FOR NEW GRADUATE STUDENTS. Laura I. Gil Pineda 1656-FlashTalk 10:00 am VISUALIZATION AND SIMULATION OF COORDINATED ACTIVITIES AT THE DNA REPLICATION FORK. Jason D. Kahn , Ian E. Morrill, Holly R. Heme sath, Alexander G. Lee, Ty J. Bolling 1657-FlashTalk 10:05 am ENHANCING MICROSCOPY IMAGE ANALYSIS WITH STREAMLINED DEEP LEARNING-BASED 3D SEGMENTATION. Suraj Mishra , Sandra Oluoch, Benjamin Morris, Amil Khan, Brian Kim, Chris Hughes, Daniel Saelid, Thao Do, Ritvik Vasan, . Allen Institute for Cell Science, Jianxu Chen, Matheus Palhares Viana, Graham Johnson, Susanne M. Rafelski 1658-FlashTalk 10:10 am THE ATLAS OF BACTERIAL AND ARCHAEAL CELL STRUCTURE. Rachel Webb , Catherine Oikonomou, Grant J. Jensen Platform Motor Proteins and Cytoskeletons II 8:15 am - 10:15 am, Room 511ABC Co-Chairs Jiayi Chen, NIH, USA Ekaterina Grishchuk, University of Pennsylvania, USA 1659-Plat 8:15 am UNCONVENTIONAL GLIDING OF KINETOCHORE-ASSOCIATED NDC80 PROTEIN ALONG MICROTUBULES UNDER DRAGGING FORCE. Ekaterina L. Grishchuk , Vladimir Demidov, Fedor Balabin, Ivan V. Gonchar, Fazly I. Ataullakhanov

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